Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,051–26,075 of 27,380 studies, newest first · page 1043 of 1096.
December 1997 4
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1997-12-01
The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled
45/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: The carboxyl-terminal phosphotyrosine binding domain of FE65 interacts in vivo with the beta-amyloid precursor protein, which is implicated in Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-12-01
Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham Study
66/100 ✓ Peer-reviewed How common it is Neurology
Key finding: Over a 20-year follow-up period, 198 subjects developed dementia (120 with AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-12-01
The effect of different diagnostic criteria on the prevalence of dementia
56/100 ✓ Peer-reviewed Getting a diagnosis The New England journal of medicine
Key finding: The commonly used criteria for diagnosis can differ by a factor of 10 in the number of subjects classified as having dementia.
Full summary, score breakdown and related studies → Original source
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1997-12-01
Warfarin use among patients with atrial fibrillation
50/100 ✓ Peer-reviewed Prevention and risk Stroke
Key finding: Warfarin anticoagulation with atrial fibrillation, even among "ideal" candidates, appears dramatically underutilized. +1 more finding
Full summary, score breakdown and related studies → Original source
November 1997 11
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1997-11-01
Dutch normal-pressure hydrocephalus study: prediction of outcome after shunting by resistance to outflow of cerebrospinal fluid
45/100 ✓ Peer-reviewed Digital health tools Journal of neurosurgery
Key finding: Positive predictive values were approximately 80% for an Rcsf of 10, 12, or 15 mm Hg/ml/minute, 92% for an Rcsf of 18 mm Hg/ml/minute, and 100% for an Rcsf of 24 mm Hg/ml/minute. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-11-01
Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons
52/100 ✓ Peer-reviewed Disparities Archives of neurology
Key finding: Markers of lower socioeconomic status predict risk of developing incident AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-11-01
Age-related cognitive decline and vision impairment affecting the detection of dementia syndrome in old age
45/100 ✓ Peer-reviewed Risk factors The British journal of psychiatry : the journal of mental science
Key finding: The considerable age effect requires the adaptation of cut-off values for old age. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-11-01
Quantitative neuropathology and quantitative magnetic resonance imaging of the hippocampus in temporal lobe epilepsy
55/100 ✓ Peer-reviewed Hippocampus size on brain scans Annals of neurology
Key finding: Pathologically, the HS group had a significantly higher logarithm (log) GD/ND than the controls in all hippocampal subregions, and than the EFS group in all subregions except the granule cell layer of the dentate gyrus (GCDG). +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-11-01
Sexual dimorphism of the developing human brain
41/100 ✓ Peer-reviewed Hippocampus size on brain scans Progress in neuro-psychopharmacology & biological psychiatry
Key finding: When adjusted for cerebral volume by ANCOVA only the basal ganglia demonstrated sex differences in mean volume with the caudate being relatively larger in females and the globus pallidus being relatively larger in males. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-11-01
Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
51/100 ✓ Peer-reviewed Genetics Nature Genetics
Full summary, score breakdown and related studies → Original source
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1997-11-01
Dietary fat intake and the risk of incident dementia in the Rotterdam Study
56/100 ✓ Peer-reviewed Long-term cohort studies Annals of neurology
Key finding: Cardiovascular disease has been associated with dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-11-01
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
52/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: We expressed human APP751 containing these mutations in the brains of transgenic mice. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-11-01
Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis
51/100 ✓ Peer-reviewed Lewy body dementia Journal of neurochemistry
Key finding: Some cases of autosomal dominant familial amyotrophic lateral sclerosis (FALS) are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1), suggesting that oxidative damage may play a role in ALS pathogenesis. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-11-01
Cerebral cortical astroglia from the trisomy 16 mouse, a model for down syndrome, produce neuronal cholinergic deficits in cell culture
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America
Key finding: Trisomy 21 (Down syndrome) is associated with a high incidence of Alzheimer disease and with deficits in cholinergic function in humans. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-11-01
Cerebrospinal fluid human immunodeficiency virus type 1 RNA levels are elevated in neurocognitively impaired individuals with acquired immunodeficiency syndrome. HIV Neurobehavioral Research Center Group
46/100 ✓ Peer-reviewed Caregiving Annals of neurology
Key finding: Because previous findings suggested that disease stage, lymphocytic pleocytosis, and HIV-1 RNA levels in plasma may influence CSF viral burden, these variables were examined as potential modifying factors. +2 more findings
Full summary, score breakdown and related studies → Original source
October 1997 10
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1997-10-31
Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease.
40/100 ✓ Peer-reviewed Getting a diagnosis Neurobiology of aging
This report summarizes the consensus recommendations of a panel of neuropathologists from the United States and Europe to improve the postmortem diagnostic criteria for Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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1997-10-25
Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study
55/100 ✓ Peer-reviewed Risk factors BMJ
Key finding: 46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-10-22
A Placebo-Controlled, Double-blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia
59/100 ✓ Peer-reviewed Clinical trials JAMA
Key finding: Although modest, the changes induced by EGb were objectively measured by the ADAS-Cog and were of sufficient magnitude to be recognized by the caregivers in the GERRI. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-10-01
Serum interleukin-6 levels correlate with the severity of dementia in Down syndrome and in Alzheimer's disease
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Acta neurologica Scandinavica
Key finding: These findings suggest a disease stage dependent general activation of the immune system both in sporadic AD and in DS with AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-10-01
Human neuronal nicotinic receptors
36/100 ✓ Peer-reviewed Clinical safety Progress in neurobiology
Key finding: Much of our current knowledge about the structure and function of NAChRs comes from studies carried out in other species, such as rodents and chicks, and information concerning human nicotinic receptors is still incomplete and scattered in the literature. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-10-01
Taste and smell losses in normal aging and disease
41/100 ✓ Peer-reviewed Risk factors JAMA
Key finding: Losses of taste and smell are common in the elderly and result from normal aging, certain disease states (especially Alzheimer disease), medications, surgical interventions, and environmental exposure.
Full summary, score breakdown and related studies → Original source
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1997-10-01
Common core structure of amyloid fibrils by synchrotron X-ray diffraction
36/100 ✓ Peer-reviewed Risk factors Journal of molecular biology
Key finding: Tissue deposition of normally soluble proteins as insoluble amyloid fibrils is associated with serious diseases including the systemic amyloidoses, maturity onset diabetes, Alzheimer's disease and transmissible spongiform encephalopathy. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-10-01
Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3
36/100 ✓ Peer-reviewed Drug development The Journal of biological chemistry
Key finding: These results provide new insights into how lithium mediates its effects in the central nervous system, and these findings could be exploited to develop a novel intervention for Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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1997-10-01
HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling
36/100 ✓ Peer-reviewed Drug development Proceedings of the National Academy of Sciences of the United States of America
Key finding: Reducing hop-1 activity in a sel-12 mutant background causes synthetic lethality and terminal phenotypes associated with reducing the function of the C. elegans lin-12 and glp-1 genes. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-10-01
Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
36/100 ✓ Peer-reviewed Risk genes beyond APOE Physiological reviews
Key finding: A signaling pathway involving guanosine 3',5'-cyclic monophosphate is activated by sAPP alpha and modulates the activities of potassium channels, N-methyl-D-aspartate receptors, and the transcription factor NF kappa B. +4 more findings
Full summary, score breakdown and related studies → Original source
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