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Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies
Boyle PA, Yu L, Leurgans SE, Wilson RS, Brookmeyer R, Schneider JA, Bennett DA.. Annals of neurology, 2018-12-19
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
Objective The degree to which Alzheimer's versus other neuropathologies contribute to the risk of Alzheimer's dementia is unknown. We examined the risk of Alzheimer's dementia attributable to pathologic AD and 8 other neuropathologies. Methods Participants (n = 1,161) came from 2 clinical-pathological studies of aging.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Boyle, P. A., Yu, L., Leurgans, S. E., Wilson, R. S., Brookmeyer, R., Schneider, J. A., et al. (2019). Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies. Annals of neurology. https://doi.org/10.1002/ana.25380
Vancouver
Boyle PA, Yu L, Leurgans SE, Wilson RS, Brookmeyer R, Schneider JA, et al. Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies. Annals of neurology. 2019. doi:10.1002/ana.25380. PMID: 30421454.
BibTeX
@article{boyle2019-30421454,
author = {Boyle, P. A. and Yu, L. and Leurgans, S. E. and Wilson, R. S. and Brookmeyer, R. and Schneider, J. A. and Bennett, D. A.},
title = {{Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies}},
journal = {Annals of neurology},
year = {2019},
doi = {10.1002/ana.25380},
pmid = {30421454},
url = {https://doi.org/10.1002/ana.25380}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- We examined the risk of Alzheimer's dementia attributable to pathologic AD and 8 other neuropathologies.
- Methods Participants (n = 1,161) came from 2 clinical-pathological studies of aging.
- Multivariable logistic regression models examined associations of 8 neuropathological indices with Alzheimer's dementia and quantified the percentage of cases attributable to each.
- Furthermore, because some dementia cases are not driven by common neuropathologies, we re-estimated the attributable risks after empirically adjusting for such cases.
Why it matters
This study examined the risk of Alzheimer's dementia attributable to pathologic Alzheimer's disease and eight other neuropathologies in 1,161 participants from two clinical-pathological studies of aging. It quantifies how much dementia risk is linked to different brain pathologies and does not report a treatment, cure, or prevention.
Study details
- Participants1,161
- Effect size44.1%; 41.0%; 8.9%
- Evidence strengthLow
How this study scored 63/100
Published in a leading specialty journal. Scored zero for study design and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,161 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 314 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 34.9 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 4 / 6 | Cited 16.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 42 other studies in this library |
| Still being cited | 3 / 4 | Cited 142 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author David Alan Bennett: h-index 197 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, Los Angeles: institution h-index 1,923 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30421454) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 63 / 100 | — |
What each of these 20 components measures, and what this score is not →
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