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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 13,126–13,150 of 27,380 studies, newest first · page 526 of 1096.

February 2019 25

  1. 2019-02-15

    Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

    ✓ Peer-reviewed Clinical safety Molecular neurodegeneration

    Key finding: Our in vivo model of c9FTD/ALS is the first to robustly recapitulate hallmark features derived from both sense and antisense C9orf72 repeat-associated transcripts complete with neurodegeneration and behavioral impairments. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2019-02-15

    Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies

    ✓ Peer-reviewed Prevention trials Aging cell

    Key finding: We think that a debate is needed urgently on if (and how) this strategy could be integrated in protocols to face DS-associated dementia and overall unhealthy aging.

    Full summary, score breakdown and related studies → Original source

  3. 2019-02-15

    Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer's disease pathogenesis

    ✓ Peer-reviewed Disease mechanisms Cellular and molecular life sciences : CMLS

    Key finding: The review is focused upon a panel of biomarkers that relate to different aspects of AD pathology, as well as various studies that have evaluated their diagnostic potential. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2019-02-15

    Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy

    ✓ Peer-reviewed Disease mechanisms Laboratory investigation; a journal of technical methods and pathology

    Key finding: We found that the deep learning framework is capable of identifying and quantifying NFT with a range of staining intensities and diverse morphologies.

    Full summary, score breakdown and related studies → Original source

  5. 2019-02-15

    Neighborhood Food Environment and Dementia Incidence: the Japan Gerontological Evaluation Study Cohort Survey

    ✓ Peer-reviewed Risk factors American Journal of Preventive Medicine

    Key finding: A total of 3,162 cases of dementia occurred during the follow-up. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2019-02-15

    Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer's disease: Pooled analysis from 5 cohorts

    ✓ Peer-reviewed Long-term cohort studies PloS one

    Key finding: Differences between users and non-users of insulin, metformin and sulfonylurea were assessed in each cohort for cognitive and brain MRI measures using linear regression models, and cognitive decline and dementia/AD risk using mixed effect models and Cox regression analyses, respectively. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2019-02-15

    Metabolic Syndrome, Mild Cognitive Impairment, and Dementia: A Meta-Analysis of Longitudinal Studies

    ✓ Peer-reviewed Mild cognitive impairment The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: No statistically significant pooled association emerged between MetS and incident dementia and AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2019-02-14

    GWAS and Beyond: Using Omics Approaches to Interpret SNP Associations

    ✓ Peer-reviewed Genetics Current genetic medicine reports

    Key finding: Neurodegenerative diseases, neuropsychiatric disorders, and related traits have highly complex etiologies but are also highly heritable and identifying the causal genes and biological pathways underlying these traits may advance the development of treatments and preventive strategies.

    Full summary, score breakdown and related studies → Original source

  9. 2019-02-14

    Dulaglutide ameliorates STZ induced AD-like impairment of learning and memory ability by modulating hyperphosphorylation of tau and NFs through GSK3β

    ✓ Peer-reviewed Drug development Biochemical and biophysical research communications

    Key finding: The results displayed that the hyperphosphorylation of tau and NFs were increased in the STZ and Ex groups compared to the control and Dul groups. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2019-02-14

    Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

    ✓ Peer-reviewed Lewy body dementia Frontiers in molecular neuroscience

    Key finding: Strikingly however, the majority of sporadic ALS patients (up to 97%) also contain the TDP-43 protein deposited in the neuronal inclusions, which suggests of its pivotal role in the ALS pathology. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2019-02-13

    Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Function, Cerebral Perfusion, and Resting-State Functional Connectivity in Patients with Dementia: A Pilot Trial

    ✓ Peer-reviewed Cognitive tests and assessment Photobiomodulation, photomedicine, and laser surgery

    Key finding: This study sought to replicate and build upon a previously published case series report describing improved cognitive function in five patients with mild-to-moderate dementia after 12 weeks of transcranial and intranasal near-infrared (NIR) PBM therapy. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2019-02-13

    Predicting Alzheimer's disease progression using multi-modal deep learning approach

    ✓ Peer-reviewed Mild cognitive impairment Scientific reports

    Key finding: Our results showed that 1) our prediction model for MCI conversion to AD yielded up to 75% accuracy (area under the curve (AUC) = 0.83) when using only single modality of data separately; and 2) our prediction model achieved the best performance with 81% accuracy (AUC = 0.86) when incorporating longitudinal multi-domain data.

    Full summary, score breakdown and related studies → Original source

  13. 2019-02-12

    Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways

    ✓ Peer-reviewed Drug development Journal of Alzheimer s Disease

    Key finding: In MCI/AD, both the CSF and serum samples had significantly elevated mean levels of C-peptide and an incretin, and reduced expression of Visfatin, whereas only CSF showed significant reductions in insulin and leptin and only serum had increased glucagon, PAI-1, and ghrelin. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2019-02-12

    Machine learning in mental health: a scoping review of methods and applications

    ✓ Peer-reviewed Digital health tools Psychological medicine

    Key finding: Overall, the application of ML to mental health has demonstrated a range of benefits across the areas of diagnosis, treatment and support, research, and clinical administration. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2019-02-12

    Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

    ✓ Peer-reviewed Risk factors Cell death & disease

    Key finding: The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2019-02-12

    Association between circadian rhythms and neurodegenerative diseases

    ✓ Peer-reviewed Risk factors The Lancet. Neurology

    Key finding: Evidence from preliminary studies suggest that circadian rhythm disruptions, in addition to being a symptom of neurodegeneration, might also be a potential risk factor for developing Alzheimer's disease and related dementias, and Parkinson's disease, although large, longitudinal studies are needed to confirm this relationship.

    Full summary, score breakdown and related studies → Original source

  17. 2019-02-12

    Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model

    ✓ Peer-reviewed Biomarkers Molecular neurobiology

    Key finding: Our results indicated that hesperetin significantly attenuated oxidative stress, as assessed by the expression of Nrf2/HO-1 and LPO and ROS assays, in the hippocampus, cortex, and in vitro HT22 cells. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2019-02-12

    Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation

    ✓ Peer-reviewed TREM2 and immune genetics Neurochemical research

    Key finding: However, the related molecular mechanisms remain poorly understood. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2019-02-12

    Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study

    ✓ Peer-reviewed Caregiving The Lancet. Neurology

    Key finding: Incidence of dementia is nearly 50 times higher in the year after a major stroke compared with that in the general population, but excess risk is substantially lower after transient ischaemic attack and minor stroke.

    Full summary, score breakdown and related studies → Original source

  20. 2019-02-11

    Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system Nature neuroscience

    Key finding: Our findings suggest that impaired removal of defective mitochondria is a pivotal event in AD pathogenesis and that mitophagy represents a potential therapeutic intervention.

    Full summary, score breakdown and related studies → Original source

  21. 2019-02-11

    Neuroinflammation and fractalkine signaling in Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Journal of neuroinflammation

    Key finding: These differential effects may explain recent studies reporting seemingly conflicting results regarding the effect of FKN over expression on AD pathologies.

    Full summary, score breakdown and related studies → Original source

  22. 2019-02-11

    MAPT mutations, tauopathy, and mechanisms of neurodegeneration

    ✓ Peer-reviewed Lewy body dementia Laboratory investigation; a journal of technical methods and pathology

    Key finding: However, large gaps in our knowledge remain regarding how various FTDP-17-linked tau mutations promote tau aggregation and neurodegeneration, and, more generally, how the tauopathy is linked to neurodegeneration. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2019-02-11

    Cigarette smoking and gray matter brain volumes in middle age adults: the CARDIA Brain MRI sub-study

    ✓ Peer-reviewed Disparities Translational psychiatry

    Key finding: Cigarette smoking has been associated with dementia and dementia-related brain changes, notably gray matter (GM) volume atrophy. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2019-02-10

    Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders

    ✓ Peer-reviewed Disease mechanisms Journal of food and drug analysis

    Key finding: In the past five years, some psychobiotics strains were reported to inhibit inflammation and decreased cortisol levels, resulting in an amelioration of the symptoms of anxiety and depression. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2019-02-09

    Ambroxol as a novel disease-modifying treatment for Parkinson's disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial

    ✓ Peer-reviewed Cognitive tests and assessment BMC neurology

    Key finding: Currently there are no disease-modifying treatments for Parkinson's disease dementia (PDD), a condition linked to aggregation of the protein α-synuclein in subcortical and cortical brain areas. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →