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The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR)
Sebastian Walsh, Susanne Röhr, Joaquín Migeot, Yuliya Bodryzlova, Etuini Ma’u, Simone Salemme, Charles R. Marshall, Timothy P Daly et al.. PLoS Medicine, 2026-04-28
Topic: Risk, prevention and care in population studies
Dementia is a leading health policy challenge, with cases expected to triple by 2050, particularly in low- and middle-income countries. Epidemiological evidence demonstrates falling age-specific incidence rates in high-income countries, suggesting risk can be lowered at the population level.The Population-Level Approaches to Dementia Risk Reduction (PLADRR) Research Group is a diverse, international network of researchers committed to investigating how structural, social, and environmental conditions can promote life course brain health and reduce dementia risk across the population.This Policy Forum article sets out the guiding principles of our approach, the building blocks required, our research priorities, and how PLADRR research can inform and translate into policy changes.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Walsh, S., Röhr, S., Migeot, J., Bodryzlova, Y., Ma’u, E., Salemme, S., et al. (2026). The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR). PLoS Medicine. https://doi.org/10.1371/journal.pmed.1005059
Vancouver
Walsh S, Röhr S, Migeot J, Bodryzlova Y, Ma’u E, Salemme S, et al. The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR). PLoS Medicine. 2026. doi:10.1371/journal.pmed.1005059. PMID: 42048404.
BibTeX
@article{walsh2026-42048404,
author = {Walsh, Sebastian and Röhr, Susanne and Migeot, Joaquín and Bodryzlova, Yuliya and Ma’u, Etuini and Salemme, Simone and Marshall, Charles R. and Daly, Timothy P and others},
title = {{The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR)}},
journal = {PLoS Medicine},
year = {2026},
doi = {10.1371/journal.pmed.1005059},
pmid = {42048404},
url = {https://doi.org/10.1371/journal.pmed.1005059}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Dementia is a leading health policy challenge, with cases expected to triple by 2050, particularly in low- and middle-income countries.
- Epidemiological evidence demonstrates falling age-specific incidence rates in high-income countries, suggesting risk can be lowered at the population level.The Population-Level Approaches to Dementia Risk Reduction (PLADRR) Research Group is a diverse, international network of researchers committed to investigating how structural, social, and environmental conditions can promote life course brain health and reduce dementia risk across the population.This Policy Forum article sets out the guiding principles of our approach, the building blocks required, our research priorities, and how PLADRR research can inform and translate into policy changes.
Why it matters
This policy article sets out principles for population-level approaches to reducing dementia risk, noting that age-specific incidence rates have fallen in high-income countries, which suggests risk can be lowered at the population level. It describes a research group's plans to study how structural, social and environmental conditions affect brain health across life, rather than reporting a treatment or cure.
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Study details
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (PLoS Medicine) |
| Journal's citation record | 3 / 4 | PLoS Medicine: journal h-index 350 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 4 / 6 | Cited 9.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Kaarin Jane Anstey: h-index 103 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Centre National de la Recherche Scientifique: institution h-index 2,511 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 38 institution(s) in 12 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42048404) |
| Free to read | 2 / 2 | Free to read |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1371/journal.pmed.1005059
- PubMed: 42048404
- Original source →
- Free full text: PLoS Medicine →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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