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67/100

✓ Peer-reviewed alzhub usefulness score 67 out of 100. Treatments

Topic: Risk, prevention and care in population studies

Results A total of 3290 individuals were screened, and 513 older adults (aged 60-85 years) without dementia and with hypertension, family history of dementia, and/or self-reported subjective cognitive decline were randomized. For the primary outcome, there were no statistically significant interactions between intervention groups and time of visits (P = .13). At 24 months, PACC scores increased by 0.2 units in the no-exercise group (95% CI, 0.1-0.3) and by 0.3 units in the exercise group (95% CI, 0.2-0.4), with no significant group differences (0.1 units; 95% CI, -0.1 to 0.2; P = .37). PACC scores also increased by 0.3 units in the no-IRVR group (95% CI, 0.2-0.4) and by 0.2 units in the IRVR group (95% CI, 0.1-0.3), with no significant group differences (0.1 units; 95% CI, -0.3 to 0.03; P = .12). Increases in the NIHTB-CB composite score and individual test scores with exercise or IRVR showed similar results. Conclusions and relevance In this multicenter randomized clinical trial among older adults with family history of dementia and/or self-reported subjective cognitive decline, exercise, IRVR, or both did not result in statistically significant differences in improvements in cognitive function over 24 months.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Zhang, R., Vidoni, E., Vongpatanasin, W., Kerwin, D. R., Cullum, C. M., Rossetti, H., et al. (2026). Effects of Exercise and Intensive Vascular Risk Reduction on Cognitive Function in Older Adults: A Randomized Clinical Trial. JAMA neurology. https://doi.org/10.1001/jamaneurol.2026.0359

Vancouver

Zhang R, Vidoni E, Vongpatanasin W, Kerwin DR, Cullum CM, Rossetti H, et al. Effects of Exercise and Intensive Vascular Risk Reduction on Cognitive Function in Older Adults: A Randomized Clinical Trial. JAMA neurology. 2026. doi:10.1001/jamaneurol.2026.0359. PMID: 41870419.

BibTeX

@article{zhang2026-41870419,
  author  = {Zhang, R. and Vidoni, E. and Vongpatanasin, W. and Kerwin, D. R. and Cullum, C. M. and Rossetti, H. and Stowe, A. M. and Billinger, S. A. and others},
  title   = {{Effects of Exercise and Intensive Vascular Risk Reduction on Cognitive Function in Older Adults: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2026},
  doi     = {10.1001/jamaneurol.2026.0359},
  pmid    = {41870419},
  url     = {https://doi.org/10.1001/jamaneurol.2026.0359}
}

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Key findings

Results A total of 3290 individuals were screened, and 513 older adults (aged 60-85 years) without dementia and with hypertension, family history of dementia, and/or self-reported subjective cognitive decline were randomized.
For the primary outcome, there were no statistically significant interactions between intervention groups and time of visits (P = .13).
At 24 months, PACC scores increased by 0.2 units in the no-exercise group (95% CI, 0.1-0.3) and by 0.3 units in the exercise group (95% CI, 0.2-0.4), with no significant group differences (0.1 units; 95% CI, -0.1 to 0.2; P = .37).
PACC scores also increased by 0.3 units in the no-IRVR group (95% CI, 0.2-0.4) and by 0.2 units in the IRVR group (95% CI, 0.1-0.3), with no significant group differences (0.1 units; 95% CI, -0.3 to 0.03; P = .12).
Increases in the NIHTB-CB composite score and individual test scores with exercise or IRVR showed similar results.

Why it matters

In this large randomized trial, exercise, intensive vascular risk reduction, or both did not produce statistically significant improvements in cognitive function over 24 months. This suggests these approaches did not slow cognitive decline in older adults with dementia risk factors.

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Study details

Participants3,290
Effect size63.0%
Evidence strengthHigh

How this study scored 67/100

Published in a leading specialty journal, and it is a randomised controlled trial.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	11 / 12	A randomised controlled trial (from PubMed type “Randomized Controlled Trial”)
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	3 / 4	3,290 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	1 / 2	Randomised (as stated in the record)
Times cited	1 / 7	Cited 3 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.5 citations a year over 2 year(s) since 2026
Impact for its field and year	4 / 6	Cited 14.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Ellen F. Binder: h-index 42 (OpenAlex, whole career)
Institution's track record	2 / 3	Washington University in St. Louis: institution h-index 1,962 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 10 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41870419)
Free to read	0 / 2	Behind a paywall — scores zero
Total	67 / 100	—

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