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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 51–75 of 27,380 studies, newest first · page 3 of 1096.

October 2026 25

  1. 2026-10-27

    ApoE4 and Psychosis in Neurodegenerative and Non-Neurodegenerative Disease: A Scoping Review

    ⚠ Preprint — not yet peer-reviewed Genetics Preprints.org

    Key finding: Studies were included if they assessed ApoE4 status in relation to the presence, severity, or age of onset of psychosis. +3 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  2. 2026-10-26

    Ultra-sensitive Mapping of Cell-free DNA-derived Methylomes Reveals Brain-specific Epigenetic Alterations Implicated in Alzheimer’s Disease

    ⚠ Preprint — not yet peer-reviewed Long-term cohort studies medRxiv

    Key finding: Using LABS ( L inear A mplification-based B isulfite S equencing), an ultra-sensitive linear amplification-based low-input whole-genome methylation profiling method, we demonstrated the feasibility of detecting altered methylation features in serum-derived cell-free DNA (cfDNA) between a set of age- and sex-matched pathologically-defined participants with AD and non-AD controls, from the Rush Memory and Aging Project. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  3. 2026-10-26

    Beyond “Denial”: Understanding and Responding to Help-Refusal in Dementia

    ⚠ Preprint — not yet peer-reviewed Getting a diagnosis Preprints.org

    Key finding: Evidence for interventions that reduce refusal is strongest for music during personal care and modified bathing methods, with some support for positive communication and person-centred approaches, though quality is generally low and few studies involve family caregivers in community settings. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  4. 2026-10-26

    Precision Nanocrystal Theranostics for Neurodegenerative Proteopathies: Strategies to Cross the Blood-Brain Barrier and Target Protein Aggregation

    ⚠ Preprint — not yet peer-reviewed Vascular contributions Preprints.org

    Key finding: Overall, nanocrystal-based theranostics hold promise as an integrated platform for early diagnosis, targeted intervention, and ongoing monitoring of neurodegenerative proteopathies.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  5. 2026-10-26

    Beyond reduced alpha power: a weaker temporal link between alpha and other brain rhythms in Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system medRxiv

    Key finding: At the group level, the resting alpha abnormality in AD comprises two partly nonredundant dimensions: reduced expression and a weaker temporal link between alpha and subsequent multi-rhythm activity.

    Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  6. 2026-10-26

    Network Localization of Anxiety as an Early Manifestation of Alzheimer’s Disease-related Neurodegeneration

    ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

    Key finding: Anxiety localizes to a brain circuit resembling the AD-related atrophy network, is consistent across the AD continuum and may extend beyond AD. +4 more findings

    Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  7. 2026-10-26

    Development and Preliminary Psychometric Evaluation of a Questionnaire Assessing Nursing Students’ Perceived Capability to Recognise Dementia in Women

    ⚠ Preprint — not yet peer-reviewed Risk factors Preprints.org

    Key finding: The questionnaire demonstrated promising preliminary structure and internal consistency. +4 more findings

    Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  8. 2026-10-26

    Interventions for Cognitive Impairment in Type 2 Diabetes Mellitus: An Umbrella Review of Pharmacological and Lifestyle Strategies, Mechanisms, and Clinical Implications

    ⚠ Preprint — not yet peer-reviewed Drug development medRxiv

    Key finding: SGLT2 inhibitors and GLP-1 receptor agonists have the greatest effect on cognition in T2DM, and the multi-component exercise as the most effective lifestyle component. +2 more findings

    Scored 63 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  9. 2026-10-26

    Current gaps in downstream applications of fMRI foundation models: lessons learned from BrainLM & BrainHarmonix on Prevent-AD

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv

    Key finding: For age group, the best foundation model feature, taken from BrainHarmonix’s structural (T1-weighted) encoder, slightly exceeded functional connectivity, but the difference was not significant. +1 more finding

    Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  10. 2026-10-26

    CausalDiffChem: Causal Network Restoration for Therapeutic Prioritization and Repurposing Across Diseases

    ⚠ Preprint — not yet peer-reviewed Genetics Research Square

    Key finding: Gene-level analyses further showed that high aggregate restoration could coexist with limited correction of dominant network interactions or discordant global alignment, demonstrating that network restoration, breadth and global transcriptional similarity capture complementary dimensions of therapeutic response.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  11. 2026-10-26

    The Filamin A Proteomic Switch: Solubility States and Cytoskeletal Dynamics Explain the Inverse Epidemiological Relationship Between Cancer and Alzheimer’s Disease

    ⚠ Preprint — not yet peer-reviewed Genetics Preprints.org

    Key finding: This structural configuration shields the scaffold from calpain-mediated cleavage, reconfiguring FLNA into an active motility engine driving invasive lamellipodia but stalls proteolytic processing and forces an absolute loss of the nuclear FLNA-90 tumor-suppressor brake, unleashing uninhibited c-Myc oncogenic transcription. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  12. 2026-10-26

    A family-aware All of Us benchmark for polygenic prediction and genomic machine learning

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv

    Key finding: Polygenic risk scores (PRSs) have improved substantially in predictive performance, yet results remain difficult to compare across studies that differ in cohorts, phenotype definitions, and evaluation procedures. +1 more finding

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  13. 2026-10-26

    Proteogenomics captures a midlife biological state of Alzheimer’s disease susceptibility

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv

    Key finding: Genetic and single-nucleus transcriptomic analyses demonstrated convergence of the neurostructural proteome and AD genetic architecture, highlighting enrichment in astrocyte, microglia, and endothelial pathways beyond the APOE region. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  14. 2026-10-26

    Cerebrospinal fluid α-synuclein seed amplification assay positivity identifies a prognostically distinct subgroup in amyotrophic lateral sclerosis

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

    Key finding: Strong αSyn SAA positivity was detected in 24/443 patients with ALS (5.4%); overall positivity, including weak-positive samples, was 37/443 (8.4%). +4 more findings

    Scored 48 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  15. 2026-10-25

    Anti-GABA B receptor autoimmunity causes cognitive decline by presynaptic pathology

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

    Key finding: This specific presynaptic pathology results from exclusive functional antagonism of the B1a subunit and disrupts short- and long-term synaptic plasticity, abnormally amplifies hippocampal network oscillations and coupling in vivo , and ultimately impairs memory consolidation. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  16. 2026-10-25

    Non-canonical proteoforms of the human fusiform gyrus in Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: But recent Ribo-seq studies and high throughput quantitative proteomics studies have shown that many ORFs previously annotated as non-coding are actually getting translated into proteins and these non-canonical proteins do have certain biological functions. +1 more finding

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  17. 2026-10-25

    Integrated Transcriptomic and Structural Prioritization of Sulforaphane Targets in Neurodegeneration: A Multi-Dataset In Silico Study

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: Independent cross-validation showed significant enrichment of prioritized targets in an SFN-responsive Alzheimer’s disease transcriptomic dataset (OR = 1.44, 95% CI: 1.08–1.89, p = 0.0104). +2 more findings

    Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  18. 2026-10-24

    Racial Differences and Temporal Trends in Parkinson’s and Alzheimer’s Disease-Related

    ⚠ Preprint — not yet peer-reviewed Disparities medRxiv

    Key finding: Recorded PD-related mortality was lower among Black than White adults, whereas AD-related mortality showed no statistically significant racial difference. +4 more findings

    Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  19. 2026-10-24

    Astrocytic ablation of truncated TrkB receptors reduces amyloid plaques and prevents synaptic loss in 5xFAD mice

    ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system bioRxiv

    Key finding: Together, these findings identify astrocytic TrkB.T as an important regulator of amyloid pathology and synaptic integrity in an AD mouse model. +3 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  20. 2026-10-24

    TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

    Key finding: We found that TMEM55B levels are lowered in severe Alzheimer’s Disease (AD) cases, validated from microarray, single neuron and total RNA Seq datasets from brain sections of the ROSMAP cohort. +4 more findings

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  21. 2026-10-24

    Parental Dementia History is Associated with Peripheral Immune Aging Rather than Generalized Biological and Brain Age Acceleration in Midlife

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv

    Key finding: We hypothesize that differences in epigenetic aging may contribute to this increased risk. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  22. 2026-10-24

    RNA-sequencing of butyrate-treated human lymphoblastoid cell lines shows dysregulated genes of multiple disease-related pathways

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: Pathway analysis showed that butyrate exposure of LCLs upregulated extracellular matrix, cell adhesion, junction organization, Wnt signaling, axonogenesis, and neurodevelopment pathways.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  23. 2026-10-24

    Overcoming segmentation bottlenecks in brain tissue for spatial proteomic inference at population scale

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: Across 14,765 images from 69 postmortem donors, identical Alzheimer’s disease pathology models found no significant associations after false discovery rate correction using zero-shot masks, versus four using fine-tuned masks; three linked higher OLIG2-positive fractions to greater neurofibrillary tangle and plaque burden.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  24. 2026-10-24

    Serpin A3 is Increased in Cerebral Amyloid Angiopathy and ARIA

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: Serpin A3 protein abundance was increased in cases with cerebral amyloid angiopathy and Alzheimer’s disease compared to neurological controls, both by western blot and quantitative microscopy. +3 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  25. 2026-10-24

    Alzheimer’s Disease-Associated Proteomic Changes in Olfactory Stem Cells Show Pathway-Level Transcriptomic Overlap

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: Fraction-specific proteomics identified cytoplasmic and nuclear-enriched protein abundance changes, including alterations in proteins and pathways associated with cytoskeletal organisation, RNA processing, intracellular trafficking, autophagy and mitochondrial/metabolic processes. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →