Home › Research › Risk genes beyond APOE
Research progress on ferroptosis mediated by ferritinophagy in Alzheimer′s disease
Ai-Ting Zhang, Zhong Jian-min, Pei-Wen Jia, Xian-Hui DONG. Shengming kexue, 2026-05-01
Topic: Amyloid, tau and blood-test diagnosis
Dysregulated ferritinophagy-mediated ferroptosis is a pivotal AD pathogenic target. Unresolved questions include Aβ/tau’s regulatory mechanisms on ferritinophagy, HERC2-FTH1 competitive binding to NCOA4, and NCOA4-CD63-mediated ferritin secretion. Future research should validate these mechanisms using AD models and clinical specimens, develop specific ferritinophagy modulators (small molecules, traditional Chinese medicine), and explore nanocarrier-based targeted delivery. Elucidating crosstalk with other AD pathways and establishing relevant biomarkers will enable combination therapies. Targeting this pathway shows considerable potential for the treatment of Alzheimer's disease and warrants further translational investigation.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhang, A.-T., Jian-min, Z., Jia, P.-W., & Xian-Hui, D. O. N. G. (2026). Research progress on ferroptosis mediated by ferritinophagy in Alzheimer′s disease. Shengming kexue. https://doi.org/10.3724/cbls.2026059
Vancouver
Zhang A.-T, Jian-min Z, Jia P.-W, Xian-Hui DONG. Research progress on ferroptosis mediated by ferritinophagy in Alzheimer′s disease. Shengming kexue. 2026. doi:10.3724/cbls.2026059.
BibTeX
@article{zhang2026-834e1965,
author = {Zhang, Ai-Ting and Jian-min, Zhong and Jia, Pei-Wen and Xian-Hui, D. O. N. G.},
title = {{Research progress on ferroptosis mediated by ferritinophagy in Alzheimer′s disease}},
journal = {Shengming kexue},
year = {2026},
doi = {10.3724/cbls.2026059},
url = {https://doi.org/10.3724/cbls.2026059}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Dysregulated ferritinophagy-mediated ferroptosis is a pivotal AD pathogenic target.
- Unresolved questions include Aβ/tau’s regulatory mechanisms on ferritinophagy, HERC2-FTH1 competitive binding to NCOA4, and NCOA4-CD63-mediated ferritin secretion.
- Future research should validate these mechanisms using AD models and clinical specimens, develop specific ferritinophagy modulators (small molecules, traditional Chinese medicine), and explore nanocarrier-based targeted delivery.
- Elucidating crosstalk with other AD pathways and establishing relevant biomarkers will enable combination therapies.
- Targeting this pathway shows considerable potential for the treatment of Alzheimer's disease and warrants further translational investigation.
Why it matters
This review proposes that dysregulated ferritinophagy-mediated ferroptosis is a pathogenic target in Alzheimer's disease and outlines unresolved questions and future research directions. It calls for validation in models and clinical specimens and for development of specific modulators, so no treatment or cure is yet available.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 27/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 26 of the 96 points we could judge it on, which is 27 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Shengming kexue) |
| Journal's citation record | 0 / 4 | Shengming kexue: journal h-index 7 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author Xian-Hui DONG holds only 1 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 0 / 3 | Hebei University of Chinese Medicine: institution h-index 92 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 26 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 26 of the 96 points we could judge it on is 27 out of 100. |
| Total | 27 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Related studies in Risk genes beyond APOE
Also in Risk genes beyond APOE
98 studies in the library are filed under Risk genes beyond APOE with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Risk genes beyond APOE hub.