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Balancing Speed and Sensitivity: Echo-Planar Accelerated MRI for ARIA-H Screening in Anti-Aβ Therapeutics
Akifumi Hagiwara. Investigative radiology, 2026-05-01
Topic: Plasma and spinal-fluid biomarkers
The recent advent of anti-amyloid-β monoclonal antibodies has introduced new demands for MRI-based screening of amyloid-related imaging abnormalities, particularly the hemorrhage subtype (ARIA-H). In this editorial, we discuss the study by Loftus and colleagues, which evaluates the diagnostic performance of echo-planar accelerated gradient-recalled echo (GRE) and susceptibility-weighted imaging (SWI) sequences for ARIA-H screening. Their results demonstrate that significant scan time reductions-up to 86%-can be achieved without substantial loss in diagnostic accuracy, particularly for accelerated GRE. These findings align with recently issued MRI guidelines and offer practical solutions for improving workflow efficiency in Alzheimer's care. However, challenges remain in terms of inter-rater variability and image quality, especially with accelerated SWI. We also highlight the emerging role of artificial intelligence-assisted analysis and the importance of reproducibility and data sharing in advancing clinical implementation. Balancing speed and sensitivity remains a central theme in optimizing imaging strategies for antiamyloid therapeutic protocols.
Key findings
- Their results demonstrate that significant scan time reductions-up to 86%-can be achieved without substantial loss in diagnostic accuracy, particularly for accelerated GRE.
- These findings align with recently issued MRI guidelines and offer practical solutions for improving workflow efficiency in Alzheimer's care.
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Study details
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 25 of the 56 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Investigative radiology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40820597) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 25 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 25 of the 56 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Hagiwara, A. (2026). Balancing Speed and Sensitivity: Echo-Planar Accelerated MRI for ARIA-H Screening in Anti-Aβ Therapeutics. Investigative radiology. https://doi.org/10.1097/rli.0000000000001232
Vancouver
Hagiwara A. Balancing Speed and Sensitivity: Echo-Planar Accelerated MRI for ARIA-H Screening in Anti-Aβ Therapeutics. Investigative radiology. 2026. doi:10.1097/rli.0000000000001232. PMID: 40820597.
BibTeX
@article{hagiwara2026-40820597,
author = {Hagiwara, Akifumi},
title = {{Balancing Speed and Sensitivity: Echo-Planar Accelerated MRI for ARIA-H Screening in Anti-Aβ Therapeutics}},
journal = {Investigative radiology},
year = {2026},
doi = {10.1097/rli.0000000000001232},
pmid = {40820597},
url = {https://doi.org/10.1097/rli.0000000000001232}
}
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