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Spinal microglia are dysregulated in a rat model of Pompe disease
Mária Nikodémová, Barry Byrne, David Fuller. Physiology, 2026-05-01
Topic: Brain proteins, microglia and lab models
Dysfunctional GAA results in widespread glycogen accumulation leading to muscle weakness, cardiovascular and breathing problems and premature death. Collectively, the results demonstrate that spinal microglia in the adult Pompe rat are not pro-inflammatory but do acquire some DAM characteristics. These findings suggest that the microglial response to Pompe disease may differ from what has been described in other neurodegenerative disorders.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Nikodémová, M., Byrne, B., & Fuller, D. (2026). Spinal microglia are dysregulated in a rat model of Pompe disease. Physiology. https://doi.org/10.1152/physiol.2026.41.s1.2299248
Vancouver
Nikodémová M, Byrne B, Fuller D. Spinal microglia are dysregulated in a rat model of Pompe disease. Physiology. 2026. doi:10.1152/physiol.2026.41.s1.2299248.
BibTeX
@article{nikodemova2026-1be8ffe0,
author = {Nikodémová, Mária and Byrne, Barry and Fuller, David},
title = {{Spinal microglia are dysregulated in a rat model of Pompe disease}},
journal = {Physiology},
year = {2026},
doi = {10.1152/physiol.2026.41.s1.2299248},
url = {https://doi.org/10.1152/physiol.2026.41.s1.2299248}
}
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Key findings
- Dysfunctional GAA results in widespread glycogen accumulation leading to muscle weakness, cardiovascular and breathing problems and premature death.
- Collectively, the results demonstrate that spinal microglia in the adult Pompe rat are not pro-inflammatory but do acquire some DAM characteristics.
- These findings suggest that the microglial response to Pompe disease may differ from what has been described in other neurodegenerative disorders.
Why it matters
This study is about spinal microglia in a rat model of Pompe disease, not Alzheimer's disease. It reports that these microglia were not pro-inflammatory but acquired some disease-associated microglia characteristics, and provides no information on treating, curing or preventing Alzheimer's.
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Study details
- Evidence strengthLow
How this study scored 27/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Physiology) |
| Journal's citation record | 2 / 4 | Physiology: journal h-index 168 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “rat”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 0 / 4 | Last-listed author David Fuller: h-index 0 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Florida: institution h-index 1,303 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 27 / 100 | — |
What each of these 20 components measures, and what this score is not →
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