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B31-13 Circadian Rest-Activity Rhythm and Alzheimer’s Disease Biomarkers in Adults With Down Syndrome
Paul A. Chung, Victoria Fleming, K Reid, D Plante, Christy L. Hom, Beau M. Ances, B Handen, Bradley T. Christian et al.. American Journal of Respiratory and Critical Care Medicine, 2026-05-01
Topic: Amyloid, tau and blood-test diagnosis
Results Of 93 participants, mean (SD) age was 39.6 (8.6) years and 41.9% were female. After adjustment, higher IV (indicating fragmentation of RAR in a 24-hour period) was associated with increased levels of pTau181 (standardized beta [β]: 0.21, p = 0.03). Higher RA (indicating robust RAR) and higher SRI (indicating consistent and regular sleep patterns) were associated with lower pTau181 (β: -0.21, p = 0.02 and β: -0.20, p = 0.03, respectively). In the subsample of participants who had amyloid PET data available at the time of analysis (n = 29), higher IV was associated with increased centiloids (β = 0.30, p = 0.04). In the exploratory analysis, higher pTau181 was associated with increased odds-ratio for MCI and AD (OR: 1.021, 95% CI: 1.004 to 1.038; p = 0.02). Conclusion These findings suggest that circadian rhythm disruption as measured via 24-hour RAR is associated with plasma and imaging biomarkers of AD in DS.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Chung, P. A., Fleming, V., Reid, K., Plante, D., Hom, C. L., Ances, B. M., et al. (2026). B31-13 Circadian Rest-Activity Rhythm and Alzheimer’s Disease Biomarkers in Adults With Down Syndrome. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1093/ajrccm/aamag162.6475
Vancouver
Chung PA, Fleming V, Reid K, Plante D, Hom CL, Ances BM, et al. B31-13 Circadian Rest-Activity Rhythm and Alzheimer’s Disease Biomarkers in Adults With Down Syndrome. American Journal of Respiratory and Critical Care Medicine. 2026. doi:10.1093/ajrccm/aamag162.6475.
BibTeX
@article{chung2026-02ad0ff8,
author = {Chung, Paul A. and Fleming, Victoria and Reid, K and Plante, D and Hom, Christy L. and Ances, Beau M. and Handen, B and Christian, Bradley T. and others},
title = {{B31-13 Circadian Rest-Activity Rhythm and Alzheimer’s Disease Biomarkers in Adults With Down Syndrome}},
journal = {American Journal of Respiratory and Critical Care Medicine},
year = {2026},
doi = {10.1093/ajrccm/aamag162.6475},
url = {https://doi.org/10.1093/ajrccm/aamag162.6475}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Results Of 93 participants, mean (SD) age was 39.6 (8.6) years and 41.9% were female.
- After adjustment, higher IV (indicating fragmentation of RAR in a 24-hour period) was associated with increased levels of pTau181 (standardized beta [β]: 0.21, p = 0.03).
- Higher RA (indicating robust RAR) and higher SRI (indicating consistent and regular sleep patterns) were associated with lower pTau181 (β: -0.21, p = 0.02 and β: -0.20, p = 0.03, respectively).
- In the subsample of participants who had amyloid PET data available at the time of analysis (n = 29), higher IV was associated with increased centiloids (β = 0.30, p = 0.04).
- In the exploratory analysis, higher pTau181 was associated with increased odds-ratio for MCI and AD (OR: 1.021, 95% CI: 1.004 to 1.038; p = 0.02).
Why it matters
In adults with Down syndrome, more fragmented rest-activity rhythms were associated with higher pTau181 and, in a small subsample, with more amyloid on PET. This is a cross-sectional association and does not show that changing sleep or circadian rhythms would treat, cure or prevent Alzheimer's disease.
Study details
- Study designcross-sectional
- Participants29
- Effect size41.9%; OR: 1.021
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (American Journal of Respiratory and Critical Care Medicine) |
| Journal's citation record | 4 / 4 | American Journal of Respiratory and Critical Care Medicine: journal h-index 507 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 1 / 4 | 29 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Phyllis C. Zee: h-index 6 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 44 / 100 | — |
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