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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 451–475 of 27,380 studies, newest first · page 19 of 1096.

September 2026 25

  1. 2026-09-15

    BIOMARCADORES SANGUÍNEOS NO DIAGNÓSTICO PRECOCE DA DOENÇA DE ALZHEIMER: UMA REVISÃO INTEGRATIVA

    ✓ Peer-reviewed Tau biomarkers Revista Tópicos.

    Key finding: A DA limita a autonomia, reduz a qualidade de vida, e coloca um fardo sobre as famílias das pessoas afetadas, além de gerar milhões em gastos para os sistemas de saúde, sendo uma séria preocupação no âmbito da saúde global. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2026-09-15

    Pharmacological modulation of cGAS-STING-NLRP3 signaling by nano-immunomodulators in Alzheimer and Parkinson disease

    ✓ Peer-reviewed Risk genes beyond APOE Inflammopharmacology

    Key finding: The review further discusses AI-driven nanomedicine optimization and advanced human-relevant models, including brain-on-a-chip systems and three-dimensional (3D) bioprinting, as tools to improve translational prediction. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2026-09-15

    The interplay of PICALM with APOE ε4 on Alzheimer’s disease: clues from two longitudinal cohorts and proteomic studies

    ✓ Peer-reviewed Genetics Translational Psychiatry

    Key finding: We previously reported that the protective PICALM rs3851179 A allele was associated with slower cognitive and pathological progression among APOE ε4 carriers. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2026-09-15

    Down syndrome postmortem brains exhibit reduction in [ 18 F]nifene binding to α4β2* nicotinic acetylcholinergic receptors

    ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's bioRxiv

    Key finding: Alzheimer’s disease (AD) pathology including amyloid beta (Aβ) plaques and tau tangles accumulate with age in Down Syndrome (DS). +3 more findings

    Scored 17 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  5. 2026-09-15

    Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment

    ✓ Peer-reviewed Biomarkers JAMA

    Key finding: In a pooled sample of multiple selected cohorts of cognitively unimpaired older adults, higher plasma p-tau217 levels were consistently associated with increased risk of clinical progression and accelerated cognitive decline. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2026-09-14

    Exercise effects on balance confidence and concerns about falling in older adults with cognitive impairment: a construct-stratified meta-analysis

    ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment Research Square

    Key finding: Six trials (327 participants) assessing balance confidence with the Activities-specific Balance Confidence Scale yielded a mean difference of 4.22 points (95% CI − 0.03 to 8.46; I² = 71.2%; 95% prediction interval − 5.20 to 13.63). +4 more findings

    Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  7. 2026-09-14

    EHR-Enabled Alzheimer’s Disease Care Pathways in Primary Care: Results from a Multisite Implementation Pilot

    ⚠ Preprint — not yet peer-reviewed Getting a diagnosis Research Square

    Key finding: Implementation of an EHR-enabled AD care pathway was associated with improved adoption of guideline-concordant cognitive assessment and recommended diagnostic evaluation in primary care across three health systems. +4 more findings

    Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  8. 2026-09-14

    Cell type-specific histone acetylation landscape in Alzheimer’s disease reveals a putative role of MITF in microglia

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

    Key finding: Gene network analysis revealed downregulation of homeostatic genes in AD microglia and upregulation of immune activation, including signatures of lipid-handling and monocyte-derived macrophages. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  9. 2026-09-14

    Ion modulation restores local synaptic function in APOE4 neuronal networks despite persistent impairments in global network organization

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

    Key finding: We have previously demonstrated that ion dysfunction contributes to early AD-related network vulnerability, and that engaging synaptic plasticity mechanisms via ion modulation can restore network balance in neurodegenerative disease. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  10. 2026-09-14

    Association between urban green space coverage and incident Alzheimer’s disease among older adults in metropolitan South Korea: a population-based retrospective cohort study

    ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

    Key finding: Higher UGS coverage was associated with a lower risk of incident AD among older adults in urban South Korea. +3 more findings

    Scored 52 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  11. 2026-09-14

    Hybrid Computational-Human Synthesis of the Human Connectome Project: Network Stability, Lifespan Reorganization and Biomarker Potential

    ⚠ Preprint — not yet peer-reviewed Risk factors Preprints.org

    Key finding: Quantitative and qualitative analyses revealed three dominant trends: (1) inter-individual connectivity patterns exhibit high stability, supporting their utility as neural fingerprints; (2) higher-order association networks undergo postnatal maturation and exhibit age-related decline, confirming lifespan-dependent reorganization; and (3) connectomic measures increasingly function as candidate biomarkers for neuropsychiatric and neurodegenerative disorders, including schizophrenia, Alzheimer's disease, and depression. +1 more finding

    Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  12. 2026-09-14

    Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Alzheimer's Disease: Overlapping Phenotypes and Associations

    ⚠ Preprint — not yet peer-reviewed Risk factors Preprints.org

    Key finding: TBI presents acutely following injury and is associated with headache, vestibular disturbances, loss of consciousness, and post-traumatic amnesia.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  13. 2026-09-14

    Divergent amyloid trajectories distinguish normal aging from Alzheimer's disease progression

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

    Key finding: In ADNI, the learned trajectory revealed a shared early path that bifurcated into an aging branch and an AD-related branch.

    Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  14. 2026-09-14

    A sphingomyelin-cholesterol complex regulates TLR4 activation in microglia

    ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics bioRxiv

    Key finding: Together, these findings establish sphingolipid-dependent cholesterol accessibility as a key regulatory layer controlling TLR4 organization and microglial inflammatory activation, positioning SR-B1 as an upstream regulator of this lipid-signaling axis.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  15. 2026-09-14

    Quantitative Modelling of Amyloid-β Dynamics in Brain, CSF, and Plasma During Sleep and Wakefulness

    ⚠ Preprint — not yet peer-reviewed Tau biomarkers bioRxiv

    Key finding: Indwelling lumbar catheter data show elevated CSF Aβ42 levels on the second morning after a full night of sleep compared to first morning. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  16. 2026-09-14

    The protein and lipid compositions of brain apolipoprotein E particles are cell type-specific

    ⚠ Preprint — not yet peer-reviewed Tau biomarkers bioRxiv

    Key finding: Emerging evidence suggests that CNS apoE lipoproteins contribute to AD-related processes, including amyloid deposition, neuroinflammation, synaptic maintenance, and blood–brain barrier function in a cell type-specific manner. +3 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  17. 2026-09-14

    Serum Brain-Derived Neurotrophic Factor Across the Human Lifespan: A Systematic Review and Meta-Analysis

    ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE medRxiv (preprint)

    Key finding: Among older adults ([&ge;]60 years), age was negatively associated with serum BDNF (pooled Fishers z=-0.139, 95% CI -0.166 to -0.111; p < 0.0001; I{superscript 2}=0.16%). +2 more findings

    Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  18. 2026-09-14

    Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

    Key finding: White matter hyperintensities (WMH), a key MRI-marker of cerebral small vessel disease (cSVD), are common in older adults and associated with an increased risk of stroke and dementia. +4 more findings

    Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  19. 2026-09-14

    Plasma proteomics reveals stage-dependent biological remodelling in Alzheimer's disease

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

    Key finding: Baseline stage ordered Clinical Dementia Rating-Sum of Boxes trajectories, and forward within-person stage movement was associated with faster clinical worsening.

    Scored 36 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  20. 2026-09-14

    Subjective word-finding complaints in older adults: Development and preliminary psychometric evaluation of a novel self-reported questionnaire

    ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

    Key finding: Exploratory factor analysis revealed six distinct factors: SWFC coping strategies, fluency difficulties and affective impacts, SWFC-related errors, proper noun retrieval difficulties, social impacts of SWFC, and common noun retrieval difficulties. +2 more findings

    Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  21. 2026-09-14

    Diagnostic Value of Large Language Model-Extracted Gross Brain Findings in Neurodegenerative Diseases

    ⚠ Preprint — not yet peer-reviewed Lewy body dementia medRxiv (preprint)

    Key finding: Macro-average sensitivity was 0.66 for both models. +4 more findings

    Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  22. 2026-09-14

    Cognition in Whitehall II 'SuperAgers': An Analysis of Dementia Risk Factors

    ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv (preprint)

    Key finding: Higher education (OR = 1.23, SE = 0.05, 95% CI = [1.10, 1.36], p < 0.001), female sex (OR = 1.30, SE = 0.09, 95% CI = [1.10, 1.55], p = 0.003), and lower age (OR = 0.67, SE = 0.04, 95% CI = [0.61, 0.73], p < 0.001) were associated with increased odds of SuperAger status. +4 more findings

    Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  23. 2026-09-14

    Eficacia del lecanemab en el tratamiento de la Enfermedad de Alzheimer: revisión de la literatura (2015-2025)

    ✓ Peer-reviewed Treatments Zenodo (CERN European Organization for Nuclear Research)

    Key finding: Este ensayo tiene como objetivo analizar la eficacia del lecanemab como terapia modificadora de la enfermedad de Alzheimer (EA).

    Full summary, score breakdown and related studies → Original source

  24. 2026-09-14

    Eficacia del lecanemab en el tratamiento de la Enfermedad de Alzheimer: revisión de la literatura (2015-2025)

    ✓ Peer-reviewed Treatments Zenodo (CERN European Organization for Nuclear Research)

    Key finding: Este ensayo tiene como objetivo analizar la eficacia del lecanemab como terapia modificadora de la enfermedad de Alzheimer (EA).

    Full summary, score breakdown and related studies → Original source

  25. 2026-09-14

    APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease

    ✓ Peer-reviewed Genetics Nature genetics

    Key finding: Notably, recent trials of anti-amyloid therapies suggest less efficacy and higher risks of severe side effects in ε4 carriers 11-13 , hampering the treatment of those with the highest unmet need. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →