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55/100

✓ Peer-reviewed alzhub usefulness score 55 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

Background Immunity has been suggested to be important in the pathogenesis of dementia. However, the contribution of innate versus adaptive immunity in the development of dementia is not clear. In this study, we aimed to investigate (1) the association between components of innate immunity (granulocytes and platelets) and adaptive immunity (lymphocytes) with risk of dementia and (2) the association between their derived ratios (granulocyte-to-lymphocyte ratio [GLR], platelet-to-lymphocyte ratio [PLR], and systemic immune-inflammation index [SII]), reflecting the balance between innate and adaptive immunity, with risk of dementia.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

van der Willik, K. D., Fani, L., Rizopoulos, D., Licher, S., Fest, J., Schagen, S. B., et al. (2019). Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study. Journal of neuroinflammation. https://doi.org/10.1186/s12974-019-1454-z

Vancouver

van der Willik KD, Fani L, Rizopoulos D, Licher S, Fest J, Schagen SB, et al. Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study. Journal of neuroinflammation. 2019. doi:10.1186/s12974-019-1454-z. PMID: 30927918.

BibTeX

@article{vanderwillik2019-30927918,
  author  = {van der Willik, K. D. and Fani, L. and Rizopoulos, D. and Licher, S. and Fest, J. and Schagen, S. B. and Ikram, M. K. and Ikram, M. A.},
  title   = {{Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study}},
  journal = {Journal of neuroinflammation},
  year    = {2019},
  doi     = {10.1186/s12974-019-1454-z},
  pmid    = {30927918},
  url     = {https://doi.org/10.1186/s12974-019-1454-z}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

However, the contribution of innate versus adaptive immunity in the development of dementia is not clear.
In this study, we aimed to investigate (1) the association between components of innate immunity (granulocytes and platelets) and adaptive immunity (lymphocytes) with risk of dementia and (2) the association between their derived ratios (granulocyte-to-lymphocyte ratio [GLR], platelet-to-lymphocyte ratio [PLR], and systemic immune-inflammation index [SII]), reflecting the balance between innate and adaptive immunity, with risk of dementia.
Methods Blood cell counts were measured repeatedly between 2002 and 2015 in dementia-free participants of the prospective population-based Rotterdam Study.
Participants were followed-up for dementia until 1 January 2016.

Why it matters

This study investigated whether blood cell counts and ratios reflecting innate versus adaptive immunity were associated with risk of dementia. It does not show that altering immune balance prevents or treats dementia, and the findings are from an observational cohort.

Study details

Participants8,313
Effect size56.9%; 8.0%
Evidence strengthLow

How this study scored 55/100

Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of neuroinflammation)
Journal's citation record	2 / 4	Journal of Neuroinflammation: journal h-index 216 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2019 — within 10 year(s) of the newest study here
Sample size	3 / 4	8,313 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 96 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.7 citations a year over 9 year(s) since 2019
Impact for its field and year	4 / 6	Cited 8.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 5 other studies in this library
Still being cited	2 / 4	Cited 35 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career)
Institution's track record	1 / 3	Erasmus MC: institution h-index 1,321 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 30927918)
Free to read	2 / 2	Free to read
Total	55 / 100	—

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