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Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration
Benjamin J Kim, Murray Grossman, Delu Song, Samantha Saludades, Wei Pan, Sophia Dominguez-Perez, Joshua L Dunaief, Tomas S Aleman et al.. Frontiers in neuroscience, 2019-04-04
Topic: Plasma and spinal-fluid biomarkers
Compared to controls, returning FTD patients (143 vs. 130 μm, p = 0.005) and the tauopathy subgroup (143 vs. 128 μm, p = 0.03) had thinner outer retinas but similar inner layer thicknesses. Compared to controls, the outer retina thinning rate was not significant for all FTD patients (p = 0.34), but was significant for the tauopathy subgroup (-3.9 vs. 0.4 μm/year, p = 0.03). Outer retina thickness change correlated with MMSE change in FTD patients (Spearman rho = 0.60, p = 0.02) and the tauopathy subgroup (rho = 0.73, p = 0.04). Our finding of FTD outer retina thinning persists and longitudinally correlates with disease progression. These findings were especially seen in probable tauopathy patients, which showed progressive outer retina thinning.
Key findings
- Compared to controls, returning FTD patients (143 vs. 130 μm, p = 0.005) and the tauopathy subgroup (143 vs. 128 μm, p = 0.03) had thinner outer retinas but similar inner layer thicknesses.
- Compared to controls, the outer retina thinning rate was not significant for all FTD patients (p = 0.34), but was significant for the tauopathy subgroup (-3.9 vs. 0.4 μm/year, p = 0.03).
- Outer retina thickness change correlated with MMSE change in FTD patients (Spearman rho = 0.60, p = 0.02) and the tauopathy subgroup (rho = 0.73, p = 0.04).
- Our finding of FTD outer retina thinning persists and longitudinally correlates with disease progression.
- These findings were especially seen in probable tauopathy patients, which showed progressive outer retina thinning.
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Study details
- Study designcross-sectional
- Participants16
- Evidence strengthModerate
How this study scored 57/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 32 of the 56 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in neuroscience) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 16 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31019447) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 32 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 32 of the 56 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Kim, B. J., Grossman, M., Song, D., Saludades, S., Pan, W., Dominguez-Perez, S., et al. (2019). Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration. Frontiers in neuroscience. https://doi.org/10.3389/fnins.2019.00298
Vancouver
Kim BJ, Grossman M, Song D, Saludades S, Pan W, Dominguez-Perez S, et al. Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration. Frontiers in neuroscience. 2019. doi:10.3389/fnins.2019.00298. PMID: 31019447.
BibTeX
@article{kim2019-31019447,
author = {Kim, Benjamin J and Grossman, Murray and Song, Delu and Saludades, Samantha and Pan, Wei and Dominguez-Perez, Sophia and Dunaief, Joshua L and Aleman, Tomas S and others},
title = {{Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration}},
journal = {Frontiers in neuroscience},
year = {2019},
doi = {10.3389/fnins.2019.00298},
pmid = {31019447},
url = {https://doi.org/10.3389/fnins.2019.00298}
}