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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 426–450 of 27,380 studies, newest first · page 18 of 1096.

September 2026 25

  1. 2026-09-17

    Integration of cell-specific gene expression and chromatin accessibility facilitates localization of neurodegenerative risk in microglia

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: Meta-analysis of these data with published human brain snRNAseq for QTL mapping identified multiple loci associated with NDDs that are restricted to either neurons or microglia. +2 more findings

    Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  2. 2026-09-17

    Proteomic markers linking anxiety phenotypes to Alzheimers disease risk: a multi-analyte proteomic analysis

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

    Key finding: ImportanceAnxiety phenotypes - rumination, global anxiety, and worry (RAW) - are increasingly associated with Alzheimers disease and related dementias (ADRD) risk, yet how anxiety phenotypes relate to coordinated, multi-system biology in the at-risk older adults is unknown. +3 more findings

    Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  3. 2026-09-17

    One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with Alzheimer's Disease

    ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv (preprint)

    Key finding: We assessed the effect of one night of CLAS, compared with one night of sham stimulation, on declarative memory retention, sleep electrophysiology, and sleep architecture. +1 more finding

    Scored 33 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  4. 2026-09-17

    Laromestrocel preserves brain volume and cognitive function in Alzheimers disease by inhibiting neuroinflammation

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

    Key finding: Here we show that laromestrocel, a mesenchymal stem cell therapy, inhibits progressive brain inflammation in subjects (n=49) with mild AD, with the strongest effect seen in core AD brain regions: the left hippocampus (25 million cells (M)x4 monthly dose group; p<0.001, N=11, and 100Mx4 group; p<0.001; N=10), the left temporal cortex (25Mx4 group; p=0.007; N=11) and left parietal cortex (25Mx4, week 26; p=0.042; N=10), and the medulla (25Mx4 group and 100Mx4; p=0.007; N=11 and N=10) after 39 weeks compared with placebo (N=9). +1 more finding

    Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  5. 2026-09-17

    Antihypertensive Medication Class and Incident Alzheimers Disease and Related Dementias: External Replication Across Two Independent Healthcare Data Sources-the Vanderbilt EHR Synthetic Derivative and US Medicare Claims

    ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

    Key finding: ObjectiveTo externally replicate and extend prior findings across two structurally independent healthcare data sources, evaluating whether predominant use of antihypertensive medications that stimulate versus inhibit angiotensin II type 2 and type 4 receptor signaling is associated with risk of inci +3 more findings

    Scored 41 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  6. 2026-09-17

    Association of plasma biomarkers with longitudinal change in age- and Alzheimer's disease-related brain atrophy patterns

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

    Key finding: INTRODUCTIONDetermining whether plasma biomarkers are preferentially associated with Alzheimers disease (AD)-related rather than age-related brain atrophy patterns may clarify their prognostic and diagnostic clinical use. +4 more findings

    Scored 36 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  7. 2026-09-17

    Is there a role for artificial intelligence in end-of-life care for persons with dementia? Perspectives of and recommendations by caregivers and hospice staff

    ✓ Peer-reviewed End-of-life care Innovation in Aging

    Key finding: Participants described AI tools as potentially helpful for obtaining information, monitoring patients, managing medications and appointments, providing companionship, and conducting logistical tasks.

    Full summary, score breakdown and related studies → Original source

  8. 2026-09-17

    Performance of Claims-based Alzheimer’s Disease and Related Dementias Algorithms in Medicare Advantage and Fee-for-Service Populations

    ✓ Peer-reviewed Health systems and care delivery The Journals of Gerontology Series A

    Key finding: Overall, both algorithms demonstrated comparable performance in MA and FFS populations, with high specificity (>97.9%) and negative predictive value [NPV] (>92.9%). +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2026-09-16

    Distinguishing Parkinsonian Disorders and Cognitive Disorder Subtypes Using Pseudocontinuous Arterial Spin Labeling

    ⚠ Preprint — not yet peer-reviewed Lewy body dementia Preprints.org

    Key finding: Four thresholds for single-patient use were fixed in writing before any study was counted, then applied descriptively rather than as eligibility criteria. +4 more findings

    Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  10. 2026-09-16

    Discovery of Bavachin as a Dual Trk-A/Trk-B Agonist via Integrated Computational Screening and Experimental Validation

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

    Key finding: Among these, Bavachin demonstrated robust, dose-dependent activation of both Trk-A and Trk-B receptors, but not Trk-C, indicating receptor selectivity. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  11. 2026-09-16

    Autonomous AI-Driven Nanoscale Spatial Mapping Reveals Novel Targets and Ternary Architectures in 5xFAD Alzheimer's Disease Model

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

    Key finding: ASCENDTM identified significant and previously unreported protein associations, including nanoscale colocalization of Aβ with postsynaptic AMPA-receptor subunit GluA2 and amyloid-bridged Aβ-GluA2-RIM1 ternary assemblies. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  12. 2026-09-16

    Regional choroid plexus calcifications and their associations with aging, brain structure, and disease

    ⚠ Preprint — not yet peer-reviewed Tau biomarkers bioRxiv

    Key finding: Greater CPcal was associated with endocrine and metabolic, psychiatric, nervous system, and circulatory disorders, with the strongest and most consistent associations observed in the 3rdV (d = 0.097 - 0.125) and persisted after adjustment for ventricular volume, particularly for diabetes (d = 0.303) and tobacco use disorder (d = 0.314). +3 more findings

    Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  13. 2026-09-16

    The longevity gene APOE2 enhances pericyte function and reduces lipid droplets

    ✓ Peer-reviewed Genetics Brain : a journal of neurology

    Key finding: Although the apolipoprotein E2 (APOE2) allele is associated with reduced AD risk and increased longevity, its impact on pericyte function is unclear. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2026-09-16

    Feasibility of remote self-administered cognitive assessment in an Alzheimer's disease treatment clinic

    ⚠ Preprint — not yet peer-reviewed Treatments medRxiv (preprint)

    Key finding: Completion rates were high across diagnostic groups and did not significantly differ by clinical severity (p=.12): CU (100%), MCI (99.1%), mild dementia (97.0%), and moderate dementia (89.5%). +2 more findings

    Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  15. 2026-09-16

    Accelerometer-Derived Relative Amplitude and Midlife Cognition: A Cross-Sectional Study

    ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv (preprint)

    Key finding: ImportanceLower relative amplitude of the rest-activity pattern has been associated with cognitive decline and incident dementia in older adults, but its relationship with domain-specific cognitive performance during midlife is less well characterized. +4 more findings

    Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  16. 2026-09-16

    Excess hypoglycaemia-related hospitalisation in older adults with comorbid type 2 diabetes and dementia: a UK Biobank cohort study

    ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

    Key finding: It remains unclear whether the combined conditions confer an excess risk of hypoglycaemia-related hospitalisation beyond the risks associated with either condition alone. +4 more findings

    Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  17. 2026-09-16

    Development and External Validation of a Plasma p-tau217-Based Model for MCI-to-Dementia Progression

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

    Key finding: At two years, observed risk was 0.214 compared with a mean predicted risk of 0.089, an observed-to-expected ratio of 2.40. +1 more finding

    Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  18. 2026-09-16

    Altered Membrane Protein Abundance in the Cerebral Cortex of the JNPL3 Mouse Model of Tauopathy

    ✓ Peer-reviewed Disease mechanisms Journal of Proteome Research

    Key finding: In addition, we found sex-associated changes in the abundances of several proteins previously reported to be involved in tau pathology, such as Reelin, DARPP-32, Zyxin, Tbce, and Gng5, in JNPL3 mice. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2026-09-16

    Artificial Intelligence–Based Detection of ARIA on MRI During Alzheimer Disease Therapy: Expert Opinion on Responsible Clinical Integration

    ✓ Peer-reviewed Treatments American Journal of Roentgenology

    Key finding: The panel concluded that AI-assisted ARIA detection is likely to enhance patient safety when used as clinical decision support within a radiologist-in-the-loop framework. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2026-09-15

    Pain is independently associated with agitation and neuropsychiatric symptoms in Alzheimer’s disease: a cross-sectional MRI study

    ⚠ Preprint — not yet peer-reviewed Clinical safety Research Square

    Key finding: Significant positive correlations were observed among pain, cognitive impairment, agitation, and neuropsychiatric symptoms (all p < 0.001). +3 more findings

    Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  21. 2026-09-15

    A locked 468-gene detoxification panel in Alzheimer's disease brain, liver, and blood: 141 high-confidence cerebral associations including lower CYP46A1 transcript abundance, and a 12-sample hepatic CYP7A1 signal

    ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

    Key finding: In brain, inverse-variance random-effects meta-analysis (DerSimonian–Laird) across six independent postmortem adult-brain GEO cohorts (GSE33000, GSE132903, GSE173955, GSE159699, GSE5281, GSE48350) yielded 458 analyzable panel genes, 167 at Benjamini–Hochberg FDR < 0.05, and 141 high-confidence genes (FDR < 0.05, measured in at least three cohorts, direction-concordant in at least 70% of cohorts, and nominally significant in at least two cohorts).

    Scored 58 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  22. 2026-09-15

    Non-coding RNAs and Mitochondrial Dysfunction in Alzheimer's Disease: A Systematic Review

    ✓ Peer-reviewed Inflammation and the immune system Molecular neurobiology

    Key finding: Among the most important candidates demonstrating clinical dysregulation, miR-140 and lncRNA NEAT1 regulate mitophagy, while miR-9, miR-34a, miR-146a, miR-155, and miR-485 are implicated in mitochondrial biogenesis and miR-204 in mitochondrial autophagy. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2026-09-15

    Structural brain imaging for newly diagnosed cognitive impairment by Medicare coverage type

    ✓ Peer-reviewed Health systems and care delivery Journal of the American College of Radiology : JACR

    Key finding: We determined the structural imaging rate overall and by Medicare coverage type: traditional Medicare, Medicare Advantage and dual eligibility for Medicare and Medicaid ("duals") and diagnosis: mild cognitive impairment (MCI) and dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2026-09-15

    The APOL1 protective M1 modifier occurs exclusively with the KIK protein haplotype to suppress channel conductance

    ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE medRxiv (preprint)

    Key finding: IntroductionGenetic studies have shown the APOL1 variant p.N264K, also called M1, is associated with markedly lower kidney disease risk when co-inherited with the G2-risk allele. +3 more findings

    Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  25. 2026-09-15

    Late Life Learning, Cognition, and Aging: A Longitudinal study of middle and older-aged adults in Beirut, Lebanon (3LC study)

    ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv (preprint)

    Key finding: ResultsThe cohort comprised 1,871 participants, including 536 UfS participants (350 previously enrolled and 186 newly enrolled) and 1,335 community participants, of whom 1,041 were age-, sex-, and education-matched to UfS participants and 294 were additionally recruited without matching. +4 more findings

    Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →