Newest studies

Shared and Divergent Multisensory Emotion Perception Deficits across Mild Cognitive Impairment, Alzheimer’s Disease, and Frontotemporal Dementia: A Systematic Review and Hierarchical Bayesian Meta-Analysis

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors PsyArXiv

Key finding: Meta-analytic results demonstrated a differential magnitude of MEP impairment across groups (FTD > AD > MCI), reflecting distinct socio-emotional vulnerabilities rather than a single disease continuum. +2 more findings

• Early Stage
• Other Dementias

Scored 56 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Docking-Guided Design and Biological Evaluation of a Lead Convolvine-Based Acetylcholinesterase Inhibitor for Alzheimer's Disease

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square

Key finding: Significant AChE inhibitory action with potency comparable to the standard was confirmed by in vitro assessment. +2 more findings

• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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T1R2/T1R3 Identified as the Aβ Receptor: A New Mechanism Linking Aβ42/40 Ratio to Neuronal Hyperexcitability in Alzheimer’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers bioRxiv

Key finding: These findings identify T1R2/T1R3 as the receptor that detects the Aβ42/40 ratio, link early Aβ changes to hyperexcitability, and point to a therapeutic target for restoring early neuronal function. +1 more finding

• Biomarkers
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Sex-specific brain reserve and progression from mild cognitive impairment to Alzheimer's disease dementia

73/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Females with MCI exhibited greater baseline GMV than males primarily in the thalamus, caudate, cerebellum, postcentral gyrus, and middle cingulate gyrus, with no differences at the AD stage. +2 more findings

• Early Stage

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Context-dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer

45/100 ✓ Peer-reviewed TREM2 and immune genetics Clinical and translational medicine

Key finding: We address translation bottlenecks-including blood-brain barrier (BBB) shuttles, human trial scarcity and soluble TREM2 (sTREM2) biomarker harmonisation-outlining a biomarker-guided, context-tailored precision therapeutic framework for targeting the TREM2 axis.

• Genetics

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Tau extent is associated with lower cognition in Down syndrome-related Alzheimer's disease

53/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: This first evaluation of 18 F-MK6240 in DS demonstrates its suitability as a sensitive biomarker for Alzheimer's disease tau pathology. +1 more finding

• Down Syndrome
• Brain Biology

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Clinical Factors Associated With Discordant Plasma P-Tau217 and Established Alzheimer Disease Biomarkers

59/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: False-positive (FP) plasma results may lead to overtreatment and false-negative (FN) results to missed or delayed disease-modifying therapies. +4 more findings

• Biomarkers

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Mapping Gut Dysbiosis in Alzheimer’s using ML

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Research Square

Key finding: Alzheimer’s disease is a progressive, currently irreversible, neurodegenerative disorder associated with the accumulation of β-Amyloid (Aβ) plaques between cells and tau (τ) tangles within cells. +4 more findings

• Brain Biology

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Newly diagnosed postoperative depression and incident dementia after major surgery: a Korean nationwide retrospective cohort study

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

Key finding: Newly diagnosed postoperative depression was associated with increased dementia risk, particularly in patients aged < 65 years, supporting prospective evaluation as a potential marker of long-term cognitive risk. +3 more findings

• Risk Factors

Scored 52 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Mobile Clinics for Brain Health Equity: A Feasibility Study of Dementia Risk Reduction in Underserved Communities

16/100 ⚠ Preprint — not yet peer-reviewed Prevention trials Research Square

Key finding: Recruitment (88.0%) and protocol fidelity (100%) met or exceeded prespecified progression criteria, whereas retention and follow-up data availability were 59.1% (13/22), slightly below the predefined 60% criterion. +4 more findings

• Health Equity
• Risk Factors
• Prevention

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Predicting Rates of Cognitive Decline in Older Adults with Brain- and Cardiac-Imputed Transcripts

16/100 ⚠ Preprint — not yet peer-reviewed Drug development medRxiv

Key finding: Changes in heart and brain tissue have been associated with cognitive decline, yet tissue-specific molecular data are difficult to obtain. +4 more findings

• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Glial Transcriptomic Convergence in Alzheimer’s and Parkinson’s Disease with Independent Retinal and Aqueous-Humor Evidence

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Preprints.org

Key finding: We then integrated healthy retinal expression, AD retinal proteomics, and PD aqueous-humor proteomics with the brain-concordance results. +2 more findings

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Evaluation of plasma neurofilament and glial fibrillary acidic protein to predict or detect amyloid related imaging abnormalities

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Baseline NfL and GFAP did not differ between patients with or without ARIA (ln[NfL] ECLIA 1.24 ± 0.38 pg/mL vs 1.25 ± 0.40 pg/mL, p = 0.77; ln[NfL] Simoa 2.87 ± 0.47 pg/mL vs 2.98 ± 0.40 pg/mL, p = 0.30, ln[GFAP] ECLIA 4.95 ± 0.36 pg/mL vs 4.88 ± 0.47 pg/mL, p = 0.69). +3 more findings

• Biomarkers

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Expert-Derived Components of Person-Centred Nursing Intervention for People with Dementia and/or Cognitive Impairment in a Hospital Experiencing Distress

16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety Research Square

Key finding: Thorough and structured assessment is essential for identifying unmet needs and managing distress in people with dementia in acute hospitals.

• Care Services

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Person-Centred Care: Impact on the Effectiveness of Palliative Care in Patients with Alzheimer’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed End-of-life care Research Square

Key finding: Sixteen eligible studies with heterogeneous designs were included, and owing to methodological and outcome variability, the results were synthesized narratively. +1 more finding

• End-of-Life Care

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Co-adapting the GRACE (Goal-diRected ACcessible, Equitable, Evidence-based Care) Dementia Post-diagnostic Support Intervention to Improve Inclusivity

16/100 ⚠ Preprint — not yet peer-reviewed Caregiving Research Square

Key finding: GRACE has demonstrated clinical and cost-effectiveness in trial settings, providing a strong foundation for wider implementation. +1 more finding

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Apigenin Improves Healthspan and Protects Against Alzheimer’s Disease-Associated Proteotoxicity in C. elegans

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

Key finding: We found that chronic exposure to apigenin extended median lifespan and improved multiple readouts of healthspan, including pharyngeal pumping, locomotor activity, and age-related macromolecular damage accumulation. +3 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Gut Microbiota–Host Metabolic Networks in Alzheimer’s Disease: From Pathological Mechanisms to Modulation by Traditional Chinese Medicine

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Authorea Preprints

Key finding: Growing evidence suggests that gut–brain communication mediated by the gut microbiota and microbiota-related metabolic signals is closely associated with AD pathology.

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Clinically Recognised Alcohol Use Disorder and Risk of Dementia Subtypes in 1.3 Million Women: A Prospective Cohort Study

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv

Key finding: Among 1,288,359 women, 20,070 with AUD were matched to 100,339 controls. +2 more findings

• Risk Factors
• Prevention
• Lifestyle

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Evaluating Diabetes Drug Targets for Vascular Dementia Prevention Using Drug Target Mendelian Randomisation

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: In primary HbA1c-scaled analyses, no antidiabetic drug target showed evidence of association with VaD risk or cerebrovascular neuroimaging markers, although DPP4 inhibition demonstrated a suggestive protective association for VaD (OR = 0.68, 95% CI = 0.46 - 1.02, p = 0.063), though the confidence interval (CI) included the null. +1 more finding

• Treatments
• Risk Factors
• Prevention

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Diagnostic Utility of Multi-Domain Language Measures Across the Alzheimer Disease Continuum

16/100 ⚠ Preprint — not yet peer-reviewed Prevention trials medRxiv

Key finding: Eight of 12 measures reached acceptable discrimination (AUC ≥ .700) for DAT vs. Semantic fluency showed the highest discrimination in each contrast, though it did not significantly outperform the NAT-S for MCI vs. In a post hoc regression, adjusting for cognitive flexibility and working memory attenuated group differences; the DAT difference was no longer significant, whereas the MCI difference remained significant. +2 more findings

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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APOE ε4 Carrier Status and Cognitive Decline in Mild-to-Moderate Alzheimer’s Disease: A Linear Mixed-Effects Analysis of the Placebo Arm of EXPEDITION 1

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: In this cohort, APOE ε4 carrier status was related to disease severity at baseline rather than to the rate of cognitive decline over 80 weeks. +2 more findings

• Clinical Trials
• Genetics

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A systems-level model of sleep-dependent memory-consolidation failure in neurodegeneration: the spindle–slow-oscillation decoupling cascade dissociates amyloid and tau

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

Key finding: We built a computer model that reproduces the rhythms and, crucially, lets the measured timing between slow waves and spindles control how strongly memories are written into cortex. +4 more findings

• Lifestyle

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Normative Modeling of Molecular-Enriched Functional Connectivity for Detecting Deviations from Healthy Brain Aging

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

Key finding: Of 204 normative reference models, 199 (97.5%) met the predefined diagnostic criteria; median held-out explained variance (EXPV) was 0.174. +1 more finding

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Regional similarity to male-typical brain architecture links childhood ADHD to neurophysiological aging in later adulthood

16/100 ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

Key finding: Our results imply that neurodevelopmental conditions could provide insights into vulnerability to suboptimal aging trajectories and could help guide early interventions targeting at-risk individuals.

• Genetics

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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