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Intersection of pathological tau and microglia at the synapse
Vogels T, Murgoci AN, Hromádka T.. Acta neuropathologica communications, 2019-07-05
Topic: Brain proteins, microglia and lab models
Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of aggregated tau and include diseases such as Alzheimer's disease (AD), progressive supranuclear palsy and chronic traumatic encephalopathy. Tau pathology is strongly linked to neurodegeneration and clinical symptoms in tauopathy patients. Furthermore, synapse loss is an early pathological event in tauopathies and is the strongest correlate of cognitive decline.
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APA 7th
Vogels, T., Murgoci, A. N., & Hromádka, T. (2019). Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. https://doi.org/10.1186/s40478-019-0754-y
Vancouver
Vogels T, Murgoci AN, Hromádka T. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. 2019. doi:10.1186/s40478-019-0754-y. PMID: 31277708.
BibTeX
@article{vogels2019-31277708,
author = {Vogels, T. and Murgoci, A. N. and Hromádka, T.},
title = {{Intersection of pathological tau and microglia at the synapse}},
journal = {Acta neuropathologica communications},
year = {2019},
doi = {10.1186/s40478-019-0754-y},
pmid = {31277708},
url = {https://doi.org/10.1186/s40478-019-0754-y}
}
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Key findings
- Tau pathology is strongly linked to neurodegeneration and clinical symptoms in tauopathy patients.
- Furthermore, synapse loss is an early pathological event in tauopathies and is the strongest correlate of cognitive decline.
- Tau pathology is additionally associated with chronic neuroinflammatory processes, such as reactive microglia, astrocytes, and increased levels of pro-inflammatory molecules (e.g. complement proteins, cytokines).
- Recent studies show that as the principal immune cells of the brain, microglia play a particularly important role in the initiation and progression of tau pathology and associated neurodegeneration.
Why it matters
This review describes how tau pathology, synapse loss and reactive microglia are linked in diseases including Alzheimer's. It summarizes disease processes rather than testing any treatment, cure or prevention.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Acta neuropathologica communications) |
| Journal's citation record | 1 / 4 | Acta Neuropathologica Communications: journal h-index 129 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 199 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 22.1 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 4 / 6 | Cited 14.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 3 / 4 | Cited 73 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Tomáš Hromádka: h-index 14 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Slovak Academy of Sciences: institution h-index 384 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31277708) |
| Free to read | 2 / 2 | Free to read |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s40478-019-0754-y
- PubMed: 31277708
- Original source →
- Free full text: Acta Neuropathologica Communications →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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