Newest studies

Visual Impairment, Eye Conditions, and Diagnoses of Neurodegeneration and Dementia

65/100 ✓ Peer-reviewed Prevention and risk JAMA Network Open

Key finding: In this cohort and MR study of UK Biobank participants, cataracts were associated with increased risk of dementia, especially vascular dementia, and reduced total brain volumes. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

The Effectiveness of Palliative Care Interventions in Long-Term Care Facilities: A Systematic Review

43/100 ✓ Peer-reviewed Health systems and care delivery Journal of personalized medicine

Key finding: The results indicate that the Program of All-Inclusive Care for the Elderly (PACE) intervention did not significantly influence overall quality of life but did improve the quality of death. +1 more finding

• Care Services
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

The pathogenicity of PSEN2 variants is tied to Aβ production and homology to PSEN1

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers bioRxiv : the preprint server for biology

Key finding: Aβ42/40 and Aβ37/42 ratios were associated with AAO across PSEN2 variants, strongly driven by PSEN2 variants with PSEN1 homologs. +3 more findings

• Genetics
• Brain Biology

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Plasma amyloid beta X-42/X-40 ratio and cognitive decline in suspected early and preclinical Alzheimer's disease

63/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We detected a significant correlation between AßX-42/X-40 in plasma and CSF (r = 0.473). +4 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Amyloid-related imaging abnormalities (ARIA): diagnosis, management, and care in the setting of amyloid-modifying therapy

45/100 ✓ Peer-reviewed Treatments Annals of clinical and translational neurology

Key finding: The wider use of aducanumab and now lecanemab warrant broader understanding by the health care provider continuum. +4 more findings

• Treatments
• Side Effects
• Diagnosis

Full summary, score breakdown and related studies → Original source

Non-coding RNAs involved in the molecular pathology of Alzheimer's disease: a systematic review

59/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in neuroscience

Key finding: Recent findings highlight the significant role of non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and piwi-interacting RNAs (piRNAs) in the molecular mechanisms underlying AD. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

The Effects of Dietary Intervention and Macrophage-Activating Factor Supplementation on Cognitive Function in Elderly Users of Outpatient Rehabilitation

53/100 ✓ Peer-reviewed Disease mechanisms Nutrients

Key finding: MAF supplementation improved cognitive function, especially after 6 months, in elderly people undergoing rehabilitation. +3 more findings

• Lifestyle
• Clinical Trials
• Brain Biology

Full summary, score breakdown and related studies → Original source

Factors associated with incentive redemption among participants in a multicenter prospective syncope clinical study

54/100 ✓ Peer-reviewed Risk factors Academic Emergency Medicine

Key finding: Incentives are a cornerstone of attracting and retaining participants in clinical research studies.1 They serve as compensation for the time and effort individuals dedicate to the research process.1 However, previous randomized clinical trials found incentivizing was not associated with increased rates of clinical trial recruitment.2, 3 Furthermore, the rate participants redeem these incentives can vary considerably.1, 4 Although numerous methods have been used to increase trial recruitment, no studies have been conducted to explore factors associated with incentive redemption, regardless of clinical area. +4 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Geographic variation in shortfalls of dementia specialists in the United States

40/100 ✓ Peer-reviewed Risk factors Health Affairs Scholar

Key finding: Using data from the Area Health Resources Files, we found that the median density of dementia specialists across hospital referral regions in United States is 28.8 per 100 000 population aged 65 years and older (interquartile range 19.3-43.6).

• Treatments

Full summary, score breakdown and related studies → Original source

Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma

46/100 ✓ Peer-reviewed TREM2 and immune genetics Cellular & molecular immunology

Key finding: Here, we investigated the phenotype, contribution, and regulatory mechanisms of lipid droplet (LD)-laden macrophages (LLMs) in hepatocellular carcinoma (HCC). +3 more findings

Full summary, score breakdown and related studies → Original source

A combination of long- and short-read genomics reveals frequent p-arm breakpoints within chromosome 21 complex genomic rearrangements

38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Genetics in medicine open

Key finding: Our results provide further insights into the architecture and underlying mechanisms of complex rearrangements on acrocentric chromosomes. +2 more findings

• Down Syndrome
• Genetics

Full summary, score breakdown and related studies → Original source

Assessing amyloid PET positivity and cognitive function in Down syndrome to guide clinical trials targeting amyloid

52/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: These findings emphasize the necessity of tailoring mAb trials for DS, considering age-related AD characteristics. +4 more findings

• Brain Scans
• Down Syndrome
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Informal caregiver and healthcare professional perspectives on dementia and nutrition

50/100 ✓ Peer-reviewed Prevention and risk Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

Key finding: Four major themes emerged: forgetting to eat, developing food aversions, strong preferences for sweets and weight changes. +4 more findings

• Lifestyle
• Caregiving

Full summary, score breakdown and related studies → Original source

A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, and lycopene in relation to increased morbidity in women after menopause

71/100 ✓ Peer-reviewed Prevention and risk Archives of gynecology and obstetrics

Key finding: We searched 122 studies, of which 90 were included in our analysis. +4 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

GLP-1 Receptor Agonists: Beyond Diabetes-What the Neurosurgeon Needs to Know

43/100 ✓ Peer-reviewed Drug development Neurosurgery practice

Key finding: Recent guidance from the American Society of Anesthesiologists demonstrates the importance of tailored management of GLP-RA drugs for surgical patients. +2 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Impact of modifications to antidementia drug reimbursement in France: Analysis of the FRA-DEM cohort

42/100 ✓ Peer-reviewed Health systems and care delivery British journal of clinical pharmacology

Key finding: Meanwhile, the use of nursing/allied healthcare and emergency care increased over the subcohort years, whereas we observed a decrease in general practitioner consultations. +1 more finding

• Treatments
• Policy

Full summary, score breakdown and related studies → Original source

Characteristics of Older Adults with Alzheimer's Disease Who Were Hospitalized during the COVID-19 Pandemic: A Secondary Data Analysis

58/100 ✓ Peer-reviewed Health systems and care delivery International journal of environmental research and public health

Key finding: Male gender (p = 0.0050) and Black race (p = 0.0069) were associated with a higher hospitalization frequency.

• Care Services

Full summary, score breakdown and related studies → Original source

Revised Criteria for Diagnosis and Staging of Alzheimer's Disease: Alzheimer's Association Workgroup

42/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & Dementia

Key finding: Alzheimer's disease can now be diagnosed based on biomarker evidence alone, even before symptoms appear +2 more findings

• Diagnosis
• Brain Biology

Full summary, score breakdown and related studies → Original source

Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study

70/100 ✓ Peer-reviewed Cognitive tests and assessment JMIR aging

Key finding: The CDR+NACC FTLD global score interacted with time on battery percentage such that participants with prodromal or symptomatic FTLD demonstrated less change in battery percentage throughout the day (a proxy for less smartphone use) than clinically normal participants (P<.001 in both cases). +3 more findings

• Digital Tools
• Other Dementias

Full summary, score breakdown and related studies → Original source

A Stochastic Landscape Approach for Protein Folding State Classification

40/100 ✓ Peer-reviewed Risk factors Journal of chemical theory and computation

Key finding: The practical application of this technique lies in its ability to provide a detailed, quantitative description of protein folding processes, with significant implications for understanding and manipulating protein behavior in industrial and pharmaceutical contexts.

Full summary, score breakdown and related studies → Original source

Diagnostic performance of plasma pTau217, pTau181, Aβ1-42 and Aβ1-40 in the LUMIPULSE automated platform for the detection of Alzheimer disease

58/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: The evaluation of blood biomarkers on an automated platform exhibited high diagnostic accuracy for AD pathophysiology, and pTau 217 showed excellent diagnostic accuracy to identify participants with AD in a consecutive sample representing the routine clinical practice in a specialized memory unit.

• Biomarkers
• Diagnosis
• Brain Biology

Full summary, score breakdown and related studies → Original source

End-of-Life and Hospice Care in Neurologic Diseases

43/100 ✓ Peer-reviewed End-of-life care Seminars in neurology

Key finding: The care of a patient with neurologic disease at end-of-life requires expertise in addressing advance care planning, hospice, symptom management, and caregiver support. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Bidirectional relationship between epigenetic age and brain health events

63/100 ✓ Peer-reviewed Genetics Nature communications

Key finding: Study participants with a prior brain health event prior to blood collection were 4% epigenetically older (beta 0.04, SE 0.01), suggesting that these conditions are associated with faster aging than that captured by chronological age. +3 more findings

Full summary, score breakdown and related studies → Original source

Investigating the relationships between motor skills, cognitive status, and area deprivation index in Arizona: a pilot study

35/100 ✓ Peer-reviewed Risk factors Frontiers in Public Health

Key finding: The findings suggest that neighborhood-level social deprivation might influence memory and motor status, primarily through its impact on motor brain health.

Full summary, score breakdown and related studies → Original source

Alzheimer Disease Cerebrospinal Fluid Biomarkers in a Tertiary Neurology Practice

47/100 ✓ Peer-reviewed Tau biomarkers Mayo Clinic proceedings

Key finding: There were 534 patients who underwent AD CSF biomarkers (Roche Elecsys Aβ42, p-Tau181, total-Tau) from April 1, 2020, through April 23, 2021. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source