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Age-Related Hearing Loss
Bowl MR, Dawson SJ.. Cold Spring Harbor perspectives in medicine, 2019-08-01
Topic: Risk, prevention and care in population studies
Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This progressive hearing impairment leads to social isolation and is also associated with comorbidities, such as frailty, falls, and late-onset depression. Moreover, there is a growing evidence linking it with cognitive decline and increased risk of dementia. Given the large social and welfare burden that results from ARHL, and because ARHL is potentially a modifiable risk factor for dementia, there is an urgent need for therapeutic interventions to ameliorate age-related auditory decline. However, a prerequisite for design of therapies is knowledge of the underlying molecular mechanisms. Currently, our understanding of ARHL is very limited. Here, we review recent findings from research into ARHL from both human and animal studies and discuss future prospects for advances in our understanding of genetic susceptibility, pathology, and potential therapeutic approaches in ARHL.
Key findings
- This progressive hearing impairment leads to social isolation and is also associated with comorbidities, such as frailty, falls, and late-onset depression.
- Moreover, there is a growing evidence linking it with cognitive decline and increased risk of dementia.
- Given the large social and welfare burden that results from ARHL, and because ARHL is potentially a modifiable risk factor for dementia, there is an urgent need for therapeutic interventions to ameliorate age-related auditory decline.
Why it matters
This review notes growing evidence linking age-related hearing loss to cognitive decline and increased dementia risk, and describes hearing loss as a potentially modifiable risk factor. It states that understanding of the underlying molecular mechanisms is very limited and that therapeutic interventions are urgently needed but not yet established.
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Study details
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on impact for its field and year, so that was left out: it earned 45 of the 94 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cold Spring Harbor perspectives in medicine) |
| Journal's citation record | 2 / 4 | Cold Spring Harbor Perspectives in Medicine: journal h-index 197 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 394 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 43.8 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 4 / 4 | Cited 231 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Sally J. Dawson: h-index 30 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30291149) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 45 / 94 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 45 of the 94 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1101/cshperspect.a033217
- PubMed: 30291149
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Bowl, M. R., & Dawson, S. J. (2019). Age-Related Hearing Loss. Cold Spring Harbor perspectives in medicine. https://doi.org/10.1101/cshperspect.a033217
Vancouver
Bowl MR, Dawson SJ. Age-Related Hearing Loss. Cold Spring Harbor perspectives in medicine. 2019. doi:10.1101/cshperspect.a033217. PMID: 30291149.
BibTeX
@article{bowl2019-30291149,
author = {Bowl, M. R. and Dawson, S. J.},
title = {{Age-Related Hearing Loss}},
journal = {Cold Spring Harbor perspectives in medicine},
year = {2019},
doi = {10.1101/cshperspect.a033217},
pmid = {30291149},
url = {https://doi.org/10.1101/cshperspect.a033217}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
4 studies in the alzhub library list this one in their references.