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Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome
Tejera D, Mercan D, Sanchez-Caro JM, Hanan M, Greenberg D, Soreq H, Latz E, Golenbock D et al.. The EMBO journal, 2019-07-30
Topic: Brain proteins, microglia and lab models
Alzheimer's disease is the most prevalent type of dementia and is caused by the deposition of extracellular amyloid-beta and abnormal tau phosphorylation. Neuroinflammation has emerged as an additional pathological component. Microglia, representing the brain's major innate immune cells, play an important role during Alzheimer's.
Key findings
- Neuroinflammation has emerged as an additional pathological component.
- Microglia, representing the brain's major innate immune cells, play an important role during Alzheimer's.
- Once activated, microglia show changes in their morphology, characterized by a retraction of cell processes.
- Systemic inflammation is known to increase the risk for cognitive decline in human neurogenerative diseases including Alzheimer's.
Why it matters
This study reports that systemic inflammation is known to increase the risk for cognitive decline in human neurodegenerative diseases including Alzheimer's, and that microglia change shape once activated. It describes a mechanism involving the NLRP3 inflammasome but reports no treatment, cure or prevention result.
Study details
- Evidence strengthLow
How this study scored 54/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The EMBO journal) |
| Journal's citation record | 4 / 4 | The EMBO Journal: journal h-index 563 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 349 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 38.8 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 4 / 6 | Cited 15.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 3 / 4 | Cited 128 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Michael Thomas Heneka: h-index 113 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Bonn: institution h-index 1,072 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31359456) |
| Free to read | 2 / 2 | Free to read |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Tejera, D., Mercan, D., Sanchez-Caro, J. M., Hanan, M., Greenberg, D., Soreq, H., et al. (2019). Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome. The EMBO journal. https://doi.org/10.15252/embj.2018101064
Vancouver
Tejera D, Mercan D, Sanchez-Caro JM, Hanan M, Greenberg D, Soreq H, et al. Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome. The EMBO journal. 2019. doi:10.15252/embj.2018101064. PMID: 31359456.
BibTeX
@article{tejera2019-31359456,
author = {Tejera, D. and Mercan, D. and Sanchez-Caro, J. M. and Hanan, M. and Greenberg, D. and Soreq, H. and Latz, E. and Golenbock, D. and others},
title = {{Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome}},
journal = {The EMBO journal},
year = {2019},
doi = {10.15252/embj.2018101064},
pmid = {31359456},
url = {https://doi.org/10.15252/embj.2018101064}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
6 studies in the alzhub library list this one in their references.