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Diabetes News
Ursula Biba, Rhea W. Teng, Martin J. Kurian, Kelly L. Close. Journal of Diabetes, 2019-08-21
Topic: Risk, prevention and care in population studies
She presented compelling data that showed the vastly improved ease of use and overall satisfaction of nasal glucagon vs its injectable counterpart. Also related to nasal glucagon, a poster presented at the meeting detailed results from a cost-offset model of nasal glucagon vs injectable glucagon, showing considerable savings per severe hypoglycemic event with Baqsimi. Savings were driven by increased likelihood of successful administration with nasal administration compared to injection.2 The model used in this study cited the aforementioned study of nasal glucagon, which found 90% success rates for nasal glucagon administration compared to 15% for injectable glucagon.2 Heart in Diabetes took place in Philadelphia, Pennsylvania from July 12-14. He also stated that the algorithm's recommendation of an SGLT-2 inhibitor for those with established CKD was very forward-thinking given that no formal renal protection studies had yet released results when the algorithm was created. Results showed significant associations between severe hypoglycemia and coronary heart disease, all-cause mortality, and cardiovascular mortality when adjusted for myriad factors.3 Nonsignificant trends toward association between severe hypoglycemia and heart failure, atrial fibrillation, and peripheral artery disease were also found.3 Dr Selvin noted that cause and effect cannot be isolated in these studies, which are not designed to investigate hypoglycemia specifically. On neurology, a later analysis of ARIC data found a nonsignificant association in older adults between severe hypoglycemia and mild cognitive impairment (adjusted OR = 1.51, 95% CI: 0.82-2-.76), and a significant association between severe hypoglycemia and dementia (adjusted OR = 2.35, 95% CI: 1.05-5.35).
Key findings
- She presented compelling data that showed the vastly improved ease of use and overall satisfaction of nasal glucagon vs its injectable counterpart.
- Also related to nasal glucagon, a poster presented at the meeting detailed results from a cost-offset model of nasal glucagon vs injectable glucagon, showing considerable savings per severe hypoglycemic event with Baqsimi.
- Savings were driven by increased likelihood of successful administration with nasal administration compared to injection.2 The model used in this study cited the aforementioned study of nasal glucagon, which found 90% success rates for nasal glucagon administration compared to 15% for injectable glucagon.2 Heart in Diabetes took place in Philadelphia, Pennsylvania from July 12-14.
- He also stated that the algorithm's recommendation of an SGLT-2 inhibitor for those with established CKD was very forward-thinking given that no formal renal protection studies had yet released results when the algorithm was created.
- Results showed significant associations between severe hypoglycemia and coronary heart disease, all-cause mortality, and cardiovascular mortality when adjusted for myriad factors.3 Nonsignificant trends toward association between severe hypoglycemia and heart failure, atrial fibrillation, and peripheral artery disease were also found.3 Dr Selvin noted that cause and effect cannot be isolated in these studies, which are not designed to investigate hypoglycemia specifically.
Why it matters
This news piece reports on nasal versus injectable glucagon for severe low blood sugar and on associations between severe hypoglycemia and heart conditions. It contains no information on treating, curing, or preventing Alzheimer's disease.
Study details
- Participants32
- Effect size90.3%; 15.6%; OR = 1.51
- Evidence strengthLow
How this study scored 32/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Diabetes) |
| Journal's citation record | 1 / 4 | Journal of Diabetes: journal h-index 76 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 32 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Kelly L. Close: h-index 28 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Close Concerns (United States): institution h-index 50 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31433564) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 32 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Biba, U., Teng, R. W., Kurian, M. J., & Close, K. L. (2019). Diabetes News. Journal of Diabetes. https://doi.org/10.1111/1753-0407.12980
Vancouver
Biba U, Teng RW, Kurian MJ, Close KL. Diabetes News. Journal of Diabetes. 2019. doi:10.1111/1753-0407.12980. PMID: 31433564.
BibTeX
@article{biba2019-31433564,
author = {Biba, Ursula and Teng, Rhea W. and Kurian, Martin J. and Close, Kelly L.},
title = {{Diabetes News}},
journal = {Journal of Diabetes},
year = {2019},
doi = {10.1111/1753-0407.12980},
pmid = {31433564},
url = {https://doi.org/10.1111/1753-0407.12980}
}
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