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Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition
Katie E Osborn, Omair A Khan, Hailey A Kresge, Corey W Bown, Dandan Liu, Elizabeth E Moore, Katherine A Gifford, Lealani Mae Y Acosta et al.. Alzheimer's & dementia (Amsterdam, Netherlands), 2019-10-22
Topic: Brain imaging, connectivity and assessment
Plasma NFL was related to all domains (P values ≤ .008) except processing speed (P values ≥ .09). CSF NFL was related to memory and language (P values ≤ .04). Interactions with cognitive diagnosis revealed widespread plasma associations, particularly in MCI participants, which were further supported in head-to-head comparison models. Plasma and CSF NFL (reflecting neuroaxonal injury) relate to cognition among non-demented older adults albeit with small to medium effects. Plasma NFL shows particular promise as an accessible biomarker with relevance to cognition in MCI.
Key findings
- Plasma NFL was related to all domains (P values ≤ .008) except processing speed (P values ≥ .09).
- CSF NFL was related to memory and language (P values ≤ .04).
- Interactions with cognitive diagnosis revealed widespread plasma associations, particularly in MCI participants, which were further supported in head-to-head comparison models.
- Plasma and CSF NFL (reflecting neuroaxonal injury) relate to cognition among non-demented older adults albeit with small to medium effects.
- Plasma NFL shows particular promise as an accessible biomarker with relevance to cognition in MCI.
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Study details
- Participants333
- Evidence strengthLow
How this study scored 52/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 29 of the 56 points we could judge it on, which is 52 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 333 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31700989) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 29 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 29 of the 56 points we could judge it on is 52 out of 100. |
| Total | 52 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Osborn, K. E., Khan, O. A., Kresge, H. A., Bown, C. W., Liu, D., Moore, E. E., et al. (2019). Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1016/j.dadm.2019.08.008
Vancouver
Osborn KE, Khan OA, Kresge HA, Bown CW, Liu D, Moore EE, et al. Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition. Alzheimer's & dementia (Amsterdam, Netherlands). 2019. doi:10.1016/j.dadm.2019.08.008. PMID: 31700989.
BibTeX
@article{osborn2019-31700989,
author = {Osborn, Katie E and Khan, Omair A and Kresge, Hailey A and Bown, Corey W and Liu, Dandan and Moore, Elizabeth E and Gifford, Katherine A and Acosta, Lealani Mae Y and others},
title = {{Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2019},
doi = {10.1016/j.dadm.2019.08.008},
pmid = {31700989},
url = {https://doi.org/10.1016/j.dadm.2019.08.008}
}
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