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47/100

✓ Peer-reviewed alzhub usefulness score 47 out of 100. Inflammation and the immune system

Topic: Brain proteins, microglia and lab models

Diabetes mellitus is one of the major risk factors for cognitive dysfunction. The pathogenesis of brain impairment caused by chronic hyperglycemia is complex and includes mitochondrial dysfunction, neuroinflammation, neurotransmitters' alteration, and vascular disease, which lead to cognitive impairment, neurodegeneration, loss of synaptic plasticity, brain aging, and dementia. Glucagon-like peptide-1 (GLP-1), a gut released hormone, is attracting attention as a possible link between metabolic and brain impairment.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Grieco, M., Giorgi, A., Gentile, M. C., d'Erme, M., Morano, S., Maras, B., et al. (2019). Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases. Frontiers in neuroscience. https://doi.org/10.3389/fnins.2019.01112

Vancouver

Grieco M, Giorgi A, Gentile MC, d'Erme M, Morano S, Maras B, et al. Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases. Frontiers in neuroscience. 2019. doi:10.3389/fnins.2019.01112. PMID: 31680842.

BibTeX

@article{grieco2019-31680842,
  author  = {Grieco, M. and Giorgi, A. and Gentile, M. C. and d'Erme, M. and Morano, S. and Maras, B. and Filardi, T.},
  title   = {{Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases}},
  journal = {Frontiers in neuroscience},
  year    = {2019},
  doi     = {10.3389/fnins.2019.01112},
  pmid    = {31680842},
  url     = {https://doi.org/10.3389/fnins.2019.01112}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

The pathogenesis of brain impairment caused by chronic hyperglycemia is complex and includes mitochondrial dysfunction, neuroinflammation, neurotransmitters' alteration, and vascular disease, which lead to cognitive impairment, neurodegeneration, loss of synaptic plasticity, brain aging, and dementia.
Glucagon-like peptide-1 (GLP-1), a gut released hormone, is attracting attention as a possible link between metabolic and brain impairment.
Several studies have shown the influence of GPL-1 on neuronal functions such as thermogenesis, blood pressure control, neurogenesis, neurodegeneration, retinal repair, and energy homeostasis.
Moreover, modulation of GLP-1 activity can influence amyloid β peptide aggregation in Alzheimer's disease (AD) and dopamine (DA) levels in Parkinson's disease (PD).

Why it matters

This review discusses glucagon-like peptide-1 as a possible link between metabolic and brain impairment in neurodegenerative diseases. It reports no treatment, cure, or prevention for Alzheimer's disease.

Study details

Evidence strengthLow

How this study scored 47/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Frontiers in neuroscience)
Journal's citation record	2 / 4	Frontiers in Neuroscience: journal h-index 226 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2019 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 218 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	24.2 citations a year over 9 year(s) since 2019
Impact for its field and year	4 / 6	Cited 13.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 3 other studies in this library
Still being cited	3 / 4	Cited 92 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Tiziana Filardi: h-index 25 (OpenAlex, whole career)
Institution's track record	1 / 3	Sapienza University of Rome: institution h-index 1,145 (OpenAlex)
Multicenter collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 31680842)
Free to read	2 / 2	Free to read
Total	47 / 100	—

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