Convergence between Microglia and… | 2020

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44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. TREM2 and immune genetics

Topic: Brain proteins, microglia and lab models

Differently from other myeloid cells, microglia derive exclusively from precursors originating within the yolk sac and migrate to the CNS under development, without any contribution from fetal liver or postnatal hematopoiesis. Consistent with their unique ontology, microglia may express specific physiological markers, which have been partly described in recent years. Here we wondered whether profiles distinguishing microglia from peripheral macrophages vary with age and under pathology.

Key findings

Consistent with their unique ontology, microglia may express specific physiological markers, which have been partly described in recent years.
Here we wondered whether profiles distinguishing microglia from peripheral macrophages vary with age and under pathology.
To this goal, we profiled transcriptomes of microglia throughout the lifespan and included a parallel comparison with peripheral macrophages under physiological and neuroinflammatory settings using age- and sex-matched wild-type and bone marrow chimera mouse models.
This comprehensive approach demonstrated that the phenotypic differentiation between microglia and peripheral macrophages is age-dependent and that peripheral macrophages do express some of the most commonly described microglia-specific markers early during development, such as Fcrls, P2ry12, Tmem119, and Trem2.

Why it matters

This study compared microglia and peripheral macrophage profiles across lifespan and in neuroinflammation. It is a basic biology study and does not test any treatment, cure or prevention for Alzheimer's disease.

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Study details

Evidence strengthLow

How this study scored 44/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Journal of neuroscience : the official journal of the Society for Neuroscience)
Journal's citation record	4 / 4	Journal of Neuroscience: journal h-index 651 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2020 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 126 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	15.8 citations a year over 8 year(s) since 2020
Impact for its field and year	3 / 6	Cited 6.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	2 / 4	Cited 33 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Gianvito Martino: h-index 82 (OpenAlex, whole career)
Institution's track record	1 / 3	IRCCS Ospedale San Raffaele: institution h-index 731 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 31818979)
Free to read	0 / 2	Behind a paywall — scores zero
Total	44 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Grassivaro, F., Menon, R., Acquaviva, M., Ottoboni, L., Ruffini, F., Bergamaschi, A., et al. (2020). Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience. https://doi.org/10.1523/jneurosci.1523-19.2019

Vancouver

Grassivaro F, Menon R, Acquaviva M, Ottoboni L, Ruffini F, Bergamaschi A, et al. Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2020. doi:10.1523/jneurosci.1523-19.2019. PMID: 31818979.

BibTeX

@article{grassivaro2020-31818979,
  author  = {Grassivaro, F. and Menon, R. and Acquaviva, M. and Ottoboni, L. and Ruffini, F. and Bergamaschi, A. and Muzio, L. and Farina, C. and others},
  title   = {{Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2020},
  doi     = {10.1523/jneurosci.1523-19.2019},
  pmid    = {31818979},
  url     = {https://doi.org/10.1523/jneurosci.1523-19.2019}
}

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