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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,676–9,700 of 27,380 studies, newest first · page 388 of 1096.

October 2021 25

  1. 2021-10-26

    Future projections of the prevalence of dementia in Japan: results from the Toyama Dementia Survey

    ✓ Peer-reviewed Disparities BMC geriatrics

    Key finding: Over the next 25 years, the prevalence of dementia in people older than 65 years is projected to exceed 25% nationwide, including metropolitan areas.

    Full summary, score breakdown and related studies → Original source

  2. 2021-10-25

    Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies

    ✓ Peer-reviewed Disease mechanisms Molecular psychiatry

    Key finding: Interestingly, M337V and A90V mutants also display dominant negative activities against WT TDP-43, partially explaining why M337V transgenic mice develop hippocampal degeneration similar to that in excitatory neuronal TDP-43 knockout mice, and why A90V mutation is associated with Alzheimer's disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2021-10-25

    Improvement in executive function for older adults through smartphone apps: a randomized clinical trial comparing language learning and brain training

    ✓ Peer-reviewed Cognitive tests and assessment Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

    Key finding: However, recently developed smartphone apps offer a convenient means to acquire skills in a second language and can be compared with brain training apps specifically designed to improve executive function. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-10-23

    Protein clearance strategies for disease intervention

    ✓ Peer-reviewed Disease mechanisms Journal of neural transmission (Vienna, Austria : 1996)

    Key finding: Growing evidence indicates that alterations in these major proteolytic mechanisms lead to a demise in proteostasis, contributing to the onset and development of distinct diseases.

    Full summary, score breakdown and related studies → Original source

  5. 2021-10-23

    Study of mirtazapine for agitated behaviours in dementia (SYMBAD): a randomised, double-blind, placebo-controlled trial

    ✓ Peer-reviewed Clinical trials Lancet (London, England)

    Key finding: Between Jan 26, 2017, and March 6, 2020, 204 participants were recruited and randomised. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-10-22

    Gut-brain axis: Synergistic approach

    ✓ Peer-reviewed Disease mechanisms Industrial psychiatry journal

    Key finding: It supports existence of far-reaching model of "gut-brain axis." +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-10-22

    Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2

    ✓ Peer-reviewed TREM2 and immune genetics Current opinion in neurobiology

    Key finding: Secretases do not only process the AD-linked neuronal amyloid precursor protein (APP) but also the triggering receptor expressed on myeloid cells 2 (TREM2), thereby controlling microglial functions. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-10-22

    Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury

    ✓ Peer-reviewed TREM2 and immune genetics Acta pharmaceutica Sinica. B

    Key finding: Here, we found that S1P or FTY720 (an analog of S1P) promoted microglial phagocytosis in stroke independent of S1PRs. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-10-21

    Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease: a systematic review

    ✓ Peer-reviewed Treatments Ageing research reviews

    Key finding: We conclude that, development of oligomer-epitope specific Aβ treatment and implementation of multiple improved biomarkers and risk prediction methods allowing early detection, together with therapies acting on other factors such as hyperexcitability in early AD, could be the key to slowing this global pandemic.

    Full summary, score breakdown and related studies → Original source

  10. 2021-10-21

    Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration

    ✓ Peer-reviewed Disease mechanisms Frontiers in neuroscience

    Key finding: Tau gene transcripts in the human brain undergo alternative splicing to yield 6 different tau protein isoforms that are expressed in different ratios in neurodegeneration which result in tau pathology of paired-helical filaments, neurofibrillary tangles, and tau fibrillar aggregates with detrimental microtubule destabilization.

    Full summary, score breakdown and related studies → Original source

  11. 2021-10-21

    Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology

    ✓ Peer-reviewed Inflammation and the immune system Nature neuroscience

    Key finding: Elucidating initial cellular pathologies is central to therapeutic target development, but obtaining samples from presymptomatic patients is not feasible. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-10-21

    Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

    ✓ Peer-reviewed Inflammation and the immune system Science (New York, N.Y.)

    Key finding: To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease, dementia with Lewy bodies, and frontotemporal dementia, we studied postmortem human samples. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-10-21

    Multi-tissue proteomics identifies molecular signatures for sporadic and genetically defined Alzheimer disease cases

    ⚠ Preprint — not yet peer-reviewed Tau biomarkers Research Square

    Key finding: Alzheimer disease (AD) is a heterogeneous disease with many genes are associated with AD risk. +3 more findings

    Scored 30 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  14. 2021-10-20

    The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)

    ✓ Peer-reviewed Prevention trials Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2021-10-19

    Metabolic Syndrome and Cognitive Function

    ✓ Peer-reviewed Risk factors Current cardiology reports

    Key finding: RECENT FINDINGS: MetS was associated with lower domain-specific and global cognitive function in most cross-sectional studies, but findings from longitudinal studies are not consistent. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-10-19

    Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review

    ✓ Peer-reviewed Digital health tools Neuroscience and biobehavioral reviews

    Key finding: Although behavioral variant frontotemporal dementia (bvFTD) is classically defined by behavioral and socio-emotional changes, impairments often extend to other cognitive functions. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2021-10-18

    Impact of Comorbid Dementia on Patterns of Hospice Use

    ✓ Peer-reviewed End-of-life care Journal of palliative medicine

    Key finding: Of 3123 decedents, 465 (14.9%) had a primary hospice diagnosis of dementia and 943 (30.2%) had comorbid dementia and died of another illness. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-10-18

    Changing demography and the challenge of dementia in India

    ✓ Peer-reviewed Disparities Nature reviews. Neurology

    Key finding: Indeed, preliminary data from recently initiated longitudinal studies in India indicate that the prevalence of vascular and metabolic risk factors, as well as white matter hyperintensities, differs between urban and rural cohorts.

    Full summary, score breakdown and related studies → Original source

  19. 2021-10-17

    Hearing Loss and Cognitive Impairment: Epidemiology, Common Pathophysiological Findings, and Treatment Considerations

    ✓ Peer-reviewed Risk factors Life (Basel, Switzerland)

    Key finding: In recent years, there has been increasing research interest in the correlation between hearing impairment and cognitive decline, two conditions that have demonstrated a strong association.

    Full summary, score breakdown and related studies → Original source

  20. 2021-10-16

    Cost–Benefit Analysis of the COPE Program for Persons Living With Dementia: Toward a Payment Model

    ✓ Peer-reviewed Health systems and care delivery Innovation in Aging

    Key finding: Per-dyad mean cost savings at 12 months were $2 354 for those who received COPE with a mean difference-in-difference of -$6 667 versus HCBS alone (95% CI: -$15 473, $2 734; not statistically significant). +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021-10-15

    Introduction to the Special Issue "The Brain-Gut Axis"

    ✓ Peer-reviewed Disease mechanisms Cellular and molecular neurobiology

    Key finding: This special Issue presents comprehensive and state-of-the-art advances in supporting the crucial role of the bidirectional interactions between the Brain-Gut Axis in health and diseases with an emphasis on the microbiome-gut-brain axis and its implications in variety of neurological disorders. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2021-10-15

    Implications of the COVID-19 Pandemic on Adult Day Services and the Families They Serve

    ✓ Peer-reviewed Health systems and care delivery American journal of Alzheimer's disease and other dementias

    Key finding: Of the 22 ADS sites responding to the survey, most (86.4%, n = 19) closed due to COVID-19 with nearly half closing due to a state mandate (52.6%, n = 10). +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-10-15

    Association of peripheral blood DNA methylation level with Alzheimer's disease progression

    ✓ Peer-reviewed Long-term cohort studies Clinical epigenetics

    Key finding: Identifying biomarkers associated with Alzheimer's disease (AD) progression may enable patient enrichment and improve clinical trial designs. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2021-10-15

    Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia

    ✓ Peer-reviewed Biomarkers Journal of neuroinflammation

    Key finding: We previously demonstrated that PNA5, a novel glycosylated angiotensin 1-7 (Ang-(1-7)) Mas receptor (MasR) agonist peptide, is an effective therapy to rescue cognitive impairment in our preclinical model of VCID. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-10-14

    Cellular and molecular influencers of neuroinflammation in Alzheimer's disease: Recent concepts & roles

    ✓ Peer-reviewed Inflammation and the immune system Neurochemistry international

    Key finding: Genome-wide association studies (GWAS) have revealed the involvement of various single nucleotide polymorphisms (SNPs) of genes related to neuroinflammation with the risk of developing AD.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →