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Cognitive correlates of cerebellar resting-state functional connectivity in Parkinson disease
Baijayanta Maiti, Jonathan M Koller, Abraham Z Snyder, Aaron B Tanenbaum, Scott A Norris, Meghan C Campbell, Joel S Perlmutter. Neurology, 2019-12-17
Topic: Brain imaging, connectivity and assessment
The participants with PD had significantly weaker FC between the vermis and peristriate visual association cortex compared to controls, and the strength of this FC correlated with visuospatial function and global cognition. In contrast, weaker FC between the vermis and dorsolateral prefrontal cortex was found in the cognitively impaired PD group compared to participants with PD without cognitive impairment. This effect correlated with deficits in attention, executive functions, and global cognition. No group differences in cerebellar lobular volumes or regional cortical thickness of the significant cortical clusters were observed. These results demonstrate a correlation between cerebellar vermal FC and cognitive impairment in PD. The absence of significant atrophy in cerebellum or relevant cortical areas suggests that this could be related to local pathophysiology such as neurotransmitter dysfunction.
Key findings
- The participants with PD had significantly weaker FC between the vermis and peristriate visual association cortex compared to controls, and the strength of this FC correlated with visuospatial function and global cognition.
- In contrast, weaker FC between the vermis and dorsolateral prefrontal cortex was found in the cognitively impaired PD group compared to participants with PD without cognitive impairment.
- This effect correlated with deficits in attention, executive functions, and global cognition.
- No group differences in cerebellar lobular volumes or regional cortical thickness of the significant cortical clusters were observed.
- These results demonstrate a correlation between cerebellar vermal FC and cognitive impairment in PD.
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Study details
- Study designcross-sectional
- Participants47
- Evidence strengthLow
How this study scored 57/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 32 of the 56 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 47 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31848257) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 32 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 32 of the 56 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
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Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Maiti, B., Koller, J. M., Snyder, A. Z., Tanenbaum, A. B., Norris, S. A., Campbell, M. C., et al. (2020). Cognitive correlates of cerebellar resting-state functional connectivity in Parkinson disease. Neurology. https://doi.org/10.1212/wnl.0000000000008754
Vancouver
Maiti B, Koller JM, Snyder AZ, Tanenbaum AB, Norris SA, Campbell MC, et al. Cognitive correlates of cerebellar resting-state functional connectivity in Parkinson disease. Neurology. 2020. doi:10.1212/wnl.0000000000008754. PMID: 31848257.
BibTeX
@article{maiti2020-31848257,
author = {Maiti, Baijayanta and Koller, Jonathan M and Snyder, Abraham Z and Tanenbaum, Aaron B and Norris, Scott A and Campbell, Meghan C and Perlmutter, Joel S},
title = {{Cognitive correlates of cerebellar resting-state functional connectivity in Parkinson disease}},
journal = {Neurology},
year = {2020},
doi = {10.1212/wnl.0000000000008754},
pmid = {31848257},
url = {https://doi.org/10.1212/wnl.0000000000008754}
}
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