Home › Research › Risk factors
Cognitive Reserve Is Not Associated With Hippocampal Microstructure in Older Adults Without Dementia
Judith Kalzendorf, Katharina Brueggen, Stefan Teipel. Frontiers in aging neuroscience, 2020-01-23
Topic: Brain imaging, connectivity and assessment
CR was not associated with hippocampal GM MD and hippocampal GM volume. Also, no interaction of amyloid status and CR was found. Our results do not confirm an association of CR and hippocampal GM MD in older adults. In contrast to previous studies, we did not find an association between CR and microstructural, nor macrostructural alterations of the hippocampus in older adults. More research is needed to determine the influence of CR on hippocampal microstructural integrity in relation to age and AD pathology.
Key findings
- CR was not associated with hippocampal GM MD and hippocampal GM volume.
- Also, no interaction of amyloid status and CR was found.
- Our results do not confirm an association of CR and hippocampal GM MD in older adults.
- In contrast to previous studies, we did not find an association between CR and microstructural, nor macrostructural alterations of the hippocampus in older adults.
- More research is needed to determine the influence of CR on hippocampal microstructural integrity in relation to age and AD pathology.
New to this subject? Start with our plain-English guide: Risk factors, ranked →
Study details
- Participants38
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 26 of the 56 points we could judge it on, which is 46 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in aging neuroscience) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 38 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32226374) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 26 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 26 of the 56 points we could judge it on is 46 out of 100. |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Kalzendorf, J., Brueggen, K., & Teipel, S. (2019). Cognitive Reserve Is Not Associated With Hippocampal Microstructure in Older Adults Without Dementia. Frontiers in aging neuroscience. https://doi.org/10.3389/fnagi.2019.00380
Vancouver
Kalzendorf J, Brueggen K, Teipel S. Cognitive Reserve Is Not Associated With Hippocampal Microstructure in Older Adults Without Dementia. Frontiers in aging neuroscience. 2019. doi:10.3389/fnagi.2019.00380. PMID: 32226374.
BibTeX
@article{kalzendorf2019-32226374,
author = {Kalzendorf, Judith and Brueggen, Katharina and Teipel, Stefan},
title = {{Cognitive Reserve Is Not Associated With Hippocampal Microstructure in Older Adults Without Dementia}},
journal = {Frontiers in aging neuroscience},
year = {2019},
doi = {10.3389/fnagi.2019.00380},
pmid = {32226374},
url = {https://doi.org/10.3389/fnagi.2019.00380}
}