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Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives
Ma L.. Frontiers in aging neuroscience, 2020-01-30
Topic: Risk, prevention and care in population studies
MCI patients have a high prevalence of depression/anxiety/apathy; furthermore, patients with MCI and concomitant depression/anxiety/apathy have more pronounced cognitive deficits and progress more often to dementia than MCI patients without depression/anxiety/apathy. Conclusions and Depression, anxiety, and apathy are common in MCI and represent possible risk factors for cognitive decline and progression to dementia. Further studies are needed to better understand the role and neurobiology of depression, anxiety, and apathy in MCI.
Key findings
- MCI patients have a high prevalence of depression/anxiety/apathy; furthermore, patients with MCI and concomitant depression/anxiety/apathy have more pronounced cognitive deficits and progress more often to dementia than MCI patients without depression/anxiety/apathy.
- Conclusions and Depression, anxiety, and apathy are common in MCI and represent possible risk factors for cognitive decline and progression to dementia.
- Further studies are needed to better understand the role and neurobiology of depression, anxiety, and apathy in MCI.
Why it matters
This review notes that depression, anxiety, and apathy are common in mild cognitive impairment and are associated with more cognitive deficits and a higher chance of progressing to dementia. These symptoms may be risk factors, but the review does not show that treating them prevents progression.
Study details
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in aging neuroscience) |
| Journal's citation record | 2 / 4 | Frontiers in Aging Neuroscience: journal h-index 174 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 324 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 40.5 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 5 / 6 | Cited 24.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 3 / 4 | Cited 169 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Lina Ma: h-index 22 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Capital Medical University: institution h-index 643 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32082139) |
| Free to read | 2 / 2 | Free to read |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fnagi.2020.00009
- PubMed: 32082139
- Original source →
- Free full text: Frontiers in Aging Neuroscience →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Ma, L. (2020). Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives. Frontiers in aging neuroscience. https://doi.org/10.3389/fnagi.2020.00009
Vancouver
Ma L. Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives. Frontiers in aging neuroscience. 2020. doi:10.3389/fnagi.2020.00009. PMID: 32082139.
BibTeX
@article{ma2020-32082139,
author = {Ma, L.},
title = {{Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives}},
journal = {Frontiers in aging neuroscience},
year = {2020},
doi = {10.3389/fnagi.2020.00009},
pmid = {32082139},
url = {https://doi.org/10.3389/fnagi.2020.00009}
}
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