Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,451–24,475 of 27,380 studies, newest first · page 979 of 1096.
June 2003 23
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2003-06-23
Autobiographical memory and autonoetic consciousness: triple dissociation in neurodegenerative diseases
47/100 ✓ Peer-reviewed Lewy body dementia Brain
Key finding: An alternative model, the multiple trace theory (MTT), suggests that the capacity of the MTL to recollect episodic memories is of a more permanent nature. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-06-16
Genetics of early-onset Alzheimer dementia
38/100 ✓ Peer-reviewed Risk genes beyond APOE TheScientificWorldJournal
Key finding: PSEN1 is the most frequently mutated EOAD gene with a mutation frequency of 18 to 50% in autosomal dominant EOAD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
The Effect of Education on Cognitive Performances and Its Implication for the Constitution of the Cognitive Reserve
47/100 ✓ Peer-reviewed Disparities Developmental Neuropsychology
Key finding: Some studies have suggested that people with a high educational level have a lower risk of developing dementia compared to people with a low educational level. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
Description of Parkinson's disease as a clinical syndrome
36/100 ✓ Peer-reviewed Risk factors Annals of the New York Academy of Sciences
Key finding: Most cases are sporadic, of unknown etiology; but rare cases of monogenic mutations (10 genes at present count) show that there are multiple causes for the neuronal degeneration. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function
36/100 ✓ Peer-reviewed Treatments Pharmacology, biochemistry, and behavior
Key finding: Some anticholinesterase (anti-ChE) alkaloids isolated from plants have been investigated for their potential in the treatment of AD, and are now in clinical use. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron
36/100 ✓ Peer-reviewed Drug development Journal of neuroscience research
Key finding: Collectively, these data suggest that GLP-1 can modify APP processing and protect against oxidative injury, two actions that suggest a novel therapeutic target for intervention in Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2003-06-01
Proteomic identification of nitrated proteins in Alzheimer's disease brain
36/100 ✓ Peer-reviewed Genetics Journal of neurochemistry
Key finding: Nitration of tyrosine in biological conditions represents a pathological event that is associated with several neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease (AD). +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-06-01
Advance care planning in nursing homes: correlates of capacity and possession of advance directives
55/100 ✓ Peer-reviewed End-of-life care The Gerontologist
Key finding: Capacity assessments revealed that most residents could state a simple treatment preference (82.4%), but a sizable number did not retain capacity to understand treatment alternatives or appreciate the consequences of their choice.
Full summary, score breakdown and related studies → Original source
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2003-06-01
The prognostic significance of subsyndromal delirium in elderly medical inpatients
52/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society
Key finding: SSD in elderly medical inpatients appears to be a clinically important syndrome that falls on a continuum between no symptoms and DSM-defined delirium. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-06-01
Causative and susceptibility genes for Alzheimer's disease: a review
44/100 ✓ Peer-reviewed Brain tissue and pathology Brain research bulletin
Key finding: Three genes have been identified as responsible for the rare early-onset familial form of the disease: the amyloid precursor protein (APP) gene, the presenilin 1 (PSEN1) gene and the presenilin 2 (PSEN2) gene. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
Screening for late life depression: cut-off scores for the Geriatric Depression Scale and the Cornell Scale for Depression in Dementia among Japanese subjects
45/100 ✓ Peer-reviewed Brain tissue and pathology International journal of geriatric psychiatry
Key finding: Proper screening of depression among older adults depends on accurate cut-off scores. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
Longitudinal outcome of Parkinson's disease patients with psychosis
59/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: Baseline data available from 59 patients enrolled in the PSYCLOPS (PSychosis and CLOzapine in PD Study) trial included age, age at onset of PD, duration of PD and psychosis, character of psychosis, medications, living setting, and scores for Mini-Mental State Examination (MMSE), Unified Parkinson's Disease Rating Scale, Hoehn and Yahr Scale, and Clinical Global Impression Scale. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
TREMs in the immune system and beyond
50/100 ✓ Peer-reviewed TREM2 and immune genetics Nature reviews. Immunology
Key finding: TREM1 and TREM2 activate myeloid cells by signalling through the adaptor protein DAP12. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach
47/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neurochemistry
Key finding: For human beings, the efficiency of this therapeutic strategy has to take into account the specificities of human amyloid, especially at the early stages of 'sporadic' Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
The 129 codon polymorphism of the prion protein gene influences earlier cognitive performance in Down syndrome subjects
37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neurology
Key finding: Recently, a frequent prion protein gene (PRNP) polymorphism consisting of a methionine (M) for valine (V) substitution at codon 129 has been associated with cognitive impairment in elderly individuals. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
Leisure activities and the risk of dementia in the elderly
71/100 ✓ Peer-reviewed How common it is The New England journal of medicine
Key finding: Participation in leisure activities is associated with a reduced risk of dementia, even after adjustment for base-line cognitive status and after the exclusion of subjects with possible preclinical dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
Efficacy of donepezil on maintenance of activities of daily living in patients with moderate to severe Alzheimer's disease and the effect on caregiver burden
64/100 ✓ Peer-reviewed Treatments Journal of the American Geriatrics Society
Key finding: The ADL benefits in AD patients treated with donepezil were associated with less caregiving time and lower levels of caregiver stress. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-06-01
Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial
46/100 ✓ Peer-reviewed Caregiving Pharmacology, biochemistry, and behavior
Key finding: (Spanish sage) extracts and constituents have demonstrated anticholinesterase, antioxidant, anti-inflammatory, oestrogenic and CNS depressant (sedative) effects all of which are currently relevant to the treatment of Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
Differences between caregivers and noncaregivers in psychological health and physical health: a meta-analysis
66/100 ✓ Peer-reviewed Caregiving Psychology and aging
Key finding: Differences in the levels of physical health in favor of noncaregivers were statistically significant, but small (g = .18).
Full summary, score breakdown and related studies → Original source
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2003-06-01
Screening for dementia in primary care: a summary of the evidence for the U.S. Preventive Services Task Force
58/100 ✓ Peer-reviewed Treatments Annals of internal medicine
Key finding: Study selection The authors developed eight key questions representing a logical chain between screening and improved health outcomes, along with eligibility criteria for admissible evidence for each question. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial
61/100 ✓ Peer-reviewed Treatments JAMA
Key finding: The results of this study indicate that rofecoxib or low-dose naproxen does not slow cognitive decline in patients with mild-to-moderate AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-06-01
Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele
48/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Inheritance of the APOE epsilon4 allele is associated with increased risk of late posttraumatic seizures. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-06 month only
Differences Between Caregivers and Noncaregivers in Psychological Health and Physical Health: A Meta-Analysis
60/100 ✓ Peer-reviewed Caregiving Psychology and Aging
Key finding: Caregivers showed higher depression (effect size g=0.58), higher stress (g=0.55), lower self-efficacy (g=0.54), and lower general well-being (g=-0.40) than non-caregivers +2 more findings
Full summary, score breakdown and related studies → Original source
May 2003 2
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2003-05-27
Idebenone treatment in Friedreich patients: One-year-long randomized placebo-controlled trial
43/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: Whereas endogenous tau was not detected in astrocytes of control mice, in GFAP/tau Tg mice there was robust astrocytic tau expression that was associated with a redistribution of the GFAP network.
Full summary, score breakdown and related studies → Original source
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2003-05-23
Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study
63/100 ✓ Peer-reviewed Mild cognitive impairment European journal of nuclear medicine and molecular imaging
Key finding: Compared with the healthy control group, a reduced rCMRglc in AD-typical regions, including the temporoparietal and posterior cingulate cortex, was detected at baseline in patients with MCI(AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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