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Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease
Wijeyekoon RS, Kronenberg-Versteeg D, Scott KM, Hayat S, Kuan WL, Evans JR, Breen DP, Cummins G et al.. Brain, behavior, and immunity, 2020-01-30
Topic: Brain proteins, microglia and lab models
The innate immune system is implicated in Parkinson's disease (PD), but peripheral in-vivo clinical evidence of the components and driving mechanisms involved and their relationship with clinical heterogeneity and progression to dementia remain poorly explored. We examined changes in peripheral innate immune-related markers in PD cases (n = 41) stratified according to risk of developing early dementia. 'Higher Risk'(HR) (n = 23) and 'Lower Risk' (LR) (n = 18) groups were defined according to neuropsychological predictors and MAPT H1/H2 genotype, and compared to age, gender and genotype-matched controls. Monocyte subsets and expression of key surface markers were measured using flow cytometry.
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APA 7th
Wijeyekoon, R. S., Kronenberg-Versteeg, D., Scott, K. M., Hayat, S., Kuan, W. L., Evans, JR., et al. (2020). Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease. Brain, behavior, and immunity. https://doi.org/10.1016/j.bbi.2020.01.018
Vancouver
Wijeyekoon RS, Kronenberg-Versteeg D, Scott KM, Hayat S, Kuan WL, Evans JR, et al. Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease. Brain, behavior, and immunity. 2020. doi:10.1016/j.bbi.2020.01.018. PMID: 32006615.
BibTeX
@article{wijeyekoon2020-32006615,
author = {Wijeyekoon, R. S. and Kronenberg-Versteeg, D. and Scott, K. M. and Hayat, S. and Kuan, W. L. and Evans, JR. and Breen, D. P. and Cummins, G. and others},
title = {{Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease}},
journal = {Brain, behavior, and immunity},
year = {2020},
doi = {10.1016/j.bbi.2020.01.018},
pmid = {32006615},
url = {https://doi.org/10.1016/j.bbi.2020.01.018}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- We examined changes in peripheral innate immune-related markers in PD cases (n = 41) stratified according to risk of developing early dementia. 'Higher Risk'(HR) (n = 23) and 'Lower Risk' (LR) (n = 18) groups were defined according to neuropsychological predictors and MAPT H1/H2 genotype, and compared to age, gender and genotype-matched controls.
- Monocyte subsets and expression of key surface markers were measured using flow cytometry.
- Serum markers including alpha-synuclein, inflammasome-related caspase-1 and bacterial translocation-related endotoxin were measured using quantitative immuno-based assays.
- Specific markers were further investigated using monocyte assays and validated in plasma samples from a larger incident PD cohort (n = 95).
Why it matters
In 41 people with Parkinson's disease grouped by dementia risk, researchers measured monocyte subsets, surface markers and serum markers including alpha-synuclein and caspase-1. This is a small observational study about immune signals in Parkinson's disease and does not directly inform Alzheimer's treatment, cure or prevention.
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Study details
- Study designlongitudinal study
- Participants41
- Evidence strengthModerate
How this study scored 59/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain, behavior, and immunity) |
| Journal's citation record | 2 / 4 | Brain Behavior and Immunity: journal h-index 249 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 41 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 105 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 13.1 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 4.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 3 / 4 | Cited 53 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Caroline H. Williams‐Gray: h-index 64 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Cambridge: institution h-index 1,973 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32006615) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.bbi.2020.01.018
- PubMed: 32006615
- Original source →
- Free full text: Brain Behavior and Immunity →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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