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Cognitive training interventions for dementia and mild cognitive impairment in Parkinson's disease
Orgeta V, McDonald KR, Poliakoff E, Hindle JV, Clare L, Leroi I.. The Cochrane database of systematic reviews, 2020-02-26
Topic: Risk, prevention and care in population studies
Selection criteria We included randomised controlled trials where the participants had PDD or PD-MCI, and where the intervention was intended to train general or specific areas of cognitive function, targeting either a single domain or multiple domains of cognition, and was compared to a control condition. We used GRADE methods to assess the overall quality of the evidence. Main results Seven studies with a total of 225 participants met the inclusion criteria for this review. We found no clear evidence that cognitive training improved global cognition. Although cognitive training was associated with higher scores on global cognition at the end of treatment, the result was imprecise and not statistically significant (6 trials, 178 participants, standardised mean difference (SMD) 0.28, 95% confidence interval (CI) -0.03 to 0.59; low-certainty evidence). We considered the certainty of the evidence for all outcomes to be low due to risk of bias in the included studies and imprecision of the results. However, this conclusion was based on a small number of studies with few participants, limitations of study design and execution, and imprecise results.
Key findings
- Selection criteria We included randomised controlled trials where the participants had PDD or PD-MCI, and where the intervention was intended to train general or specific areas of cognitive function, targeting either a single domain or multiple domains of cognition, and was compared to a control condition.
- We used GRADE methods to assess the overall quality of the evidence.
- Main results Seven studies with a total of 225 participants met the inclusion criteria for this review.
- We found no clear evidence that cognitive training improved global cognition.
- Although cognitive training was associated with higher scores on global cognition at the end of treatment, the result was imprecise and not statistically significant (6 trials, 178 participants, standardised mean difference (SMD) 0.28, 95% confidence interval (CI) -0.03 to 0.59; low-certainty evidence).
Why it matters
This review of seven trials with 225 participants found no clear evidence that cognitive training improved global cognition in people with Parkinson's disease dementia or mild cognitive impairment. The evidence was low certainty because of risk of bias, imprecision and the small number of studies and participants.
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Study details
- Participants225
- Evidence strengthHigh
How this study scored 71/100
Published in a leading specialty journal, and it is a meta-analysis pooling many studies. Scored zero for effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Cochrane database of systematic reviews) |
| Journal's citation record | 3 / 4 | Cochrane Database of Systematic Reviews: journal h-index 468 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A meta-analysis pooling many studies (from PubMed type “Meta-Analysis”) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 225 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 5 / 7 | Cited 127 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 15.9 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 4 / 6 | Cited 9.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 3 / 4 | Cited 66 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Iracema Leroi: h-index 48 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32101639) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 71 / 100 | — |
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Read the original
- DOI: 10.1002/14651858.cd011961.pub2
- PubMed: 32101639
- Original source →
- Free full text: Cochrane Database of Systematic Reviews →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Orgeta, V., McDonald, K. R., Poliakoff, E., Hindle, J. V., Clare, L., & Leroi, I. (2020). Cognitive training interventions for dementia and mild cognitive impairment in Parkinson's disease. The Cochrane database of systematic reviews. https://doi.org/10.1002/14651858.cd011961.pub2
Vancouver
Orgeta V, McDonald KR, Poliakoff E, Hindle JV, Clare L, Leroi I. Cognitive training interventions for dementia and mild cognitive impairment in Parkinson's disease. The Cochrane database of systematic reviews. 2020. doi:10.1002/14651858.cd011961.pub2. PMID: 32101639.
BibTeX
@article{orgeta2020-32101639,
author = {Orgeta, V. and McDonald, K. R. and Poliakoff, E. and Hindle, J. V. and Clare, L. and Leroi, I.},
title = {{Cognitive training interventions for dementia and mild cognitive impairment in Parkinson's disease}},
journal = {The Cochrane database of systematic reviews},
year = {2020},
doi = {10.1002/14651858.cd011961.pub2},
pmid = {32101639},
url = {https://doi.org/10.1002/14651858.cd011961.pub2}
}
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