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Brain iron deposition is linked with cognitive severity in Parkinson's disease
Thomas GEC, Leyland LA, Schrag AE, Lees AJ, Acosta-Cabronero J, Weil RS.. Journal of neurology, neurosurgery, and psychiatry, 2020-02-20
Topic: Brain proteins, microglia and lab models
Background Dementia is common in Parkinson's disease (PD) but measures that track cognitive change in PD are lacking. Brain tissue iron accumulates with age and co-localises with pathological proteins linked to PD dementia such as amyloid. We used quantitative susceptibility mapping (QSM) to detect changes related to cognitive change in PD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Thomas, G. E. C., Leyland, L. A., Schrag, A. E., Lees, A. J., Acosta-Cabronero, J., & Weil, R. S. (2020). Brain iron deposition is linked with cognitive severity in Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp-2019-322042
Vancouver
Thomas GEC, Leyland LA, Schrag AE, Lees AJ, Acosta-Cabronero J, Weil RS. Brain iron deposition is linked with cognitive severity in Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. 2020. doi:10.1136/jnnp-2019-322042. PMID: 32079673.
BibTeX
@article{thomas2020-32079673,
author = {Thomas, G. E. C. and Leyland, L. A. and Schrag, A. E. and Lees, A. J. and Acosta-Cabronero, J. and Weil, R. S.},
title = {{Brain iron deposition is linked with cognitive severity in Parkinson's disease}},
journal = {Journal of neurology, neurosurgery, and psychiatry},
year = {2020},
doi = {10.1136/jnnp-2019-322042},
pmid = {32079673},
url = {https://doi.org/10.1136/jnnp-2019-322042}
}
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Key findings
- Brain tissue iron accumulates with age and co-localises with pathological proteins linked to PD dementia such as amyloid.
- We used quantitative susceptibility mapping (QSM) to detect changes related to cognitive change in PD.
- Methods We assessed 100 patients with early-stage to mid-stage PD, and 37 age-matched controls using the Montreal Cognitive Assessment (MoCA), a validated clinical algorithm for risk of cognitive decline in PD, measures of visuoperceptual function and the Movement Disorders Society Unified Parkinson's Disease Rating Scale part 3 (UPDRS-III).
- We investigated the association between these measures and QSM, an MRI technique sensitive to brain tissue iron content.
Why it matters
This study used quantitative susceptibility mapping to detect brain iron changes related to cognitive change in Parkinson's disease. It concerns an imaging marker in Parkinson's disease and does not test treating, curing or preventing Alzheimer's disease.
Study details
- Participants100
- Evidence strengthLow
How this study scored 54/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurology, neurosurgery, and psychiatry) |
| Journal's citation record | 3 / 4 | Journal of Neurology Neurosurgery & Psychiatry: journal h-index 336 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 100 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 213 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 26.6 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 4 / 6 | Cited 10.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 3 / 4 | Cited 97 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Rimona Sharon Weil: h-index 39 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32079673) |
| Free to read | 2 / 2 | Free to read |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1136/jnnp-2019-322042
- PubMed: 32079673
- Original source →
- Free full text: Journal of Neurology Neurosurgery & Psychiatry →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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