Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,326–24,350 of 27,380 studies, newest first · page 974 of 1096.
November 2003 16
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2003-11-01
Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: These findings indicate that the prenatal environment can alter behavior, dysregulate neuroendocrine systems, and affect the hippocampal structure of primates in a persistent manner. +2 more findings
Full summary, score breakdown and related studies → Original source
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2003-11-01
End-of-life care and the effects of bereavement on family caregivers of persons with dementia
67/100 ✓ Peer-reviewed End-of-life care The New England journal of medicine
Key finding: End-of-life care for patients with dementia was extremely demanding of family caregivers. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-11-01
Genetic modifiers of tauopathy in Drosophila
36/100 ✓ Peer-reviewed Disease mechanisms Genetics
Key finding: Despite some clinical and pathological similarities among neurodegenerative disorders, a direct comparison of modifiers between different Drosophila disease models revealed that the genetic pathways controlling Tau and polyglutamine toxicity are largely distinct. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-11-01
Rey verbal learning test is a useful tool for differential diagnosis in the preclinical phase of Alzheimer's disease: comparison with mild cognitive impairment and normal aging
44/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry
Key finding: RAVLT was administered as part of a more extensive neuropsychological battery at baseline evaluation in 116 unselected patients referred by subjective memory complaints (SMC). +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-11-01
Assessment of cognition in Parkinson's disease
51/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: A literature search was conducted to identify the most frequently affected cognitive domains in PD and to select candidate items for the initial scale. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-11-01
Total tau in cerebrospinal fluid differentiates Alzheimer's disease from vascular dementia
35/100 ✓ Peer-reviewed Tau biomarkers Medical science monitor : international medical journal of experimental and clinical research
Key finding: Tau protein is a microtubule-associated protein located in neuronal axons, which has been used in various configurations as a diagnostic marker of degenerative changes in the CNS. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-11-01
Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation
40/100 ✓ Peer-reviewed Risk genes beyond APOE Cancer research
Key finding: Recent work has identified additional roles for APP in peripheral tissue, such as cellular proliferation and motility. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-11-01
Neuropathology of cognitively normal elderly
56/100 ✓ Peer-reviewed Lewy body dementia Journal of neuropathology and experimental neurology
Key finding: We found 34 subjects (87%) with a Braak stage <IV; 32 subjects (82%) with less than moderate numbers of cored plaques and 37 subjects (95%) with less than moderate numbers of tau-positive neuritic plaques.
Full summary, score breakdown and related studies → Original source
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2003-11-01
Corticobasal degeneration as a cognitive disorder
42/100 ✓ Peer-reviewed Digital health tools Movement disorders : official journal of the Movement Disorder Society
Key finding: The limb apraxia is associated with deficits in drawing, copying, and handwriting, but there is emerging evidence that the problems with handwriting are not due exclusively to the apraxia.
Full summary, score breakdown and related studies → Original source
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2003-11-01
Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease
55/100 ✓ Peer-reviewed Digital health tools The New England journal of medicine
Key finding: There was no control group, but worsening of akinesia, speech, postural stability, freezing of gait, and cognitive function between the first and the fifth year is consistent with the natural history of Parkinson's disease.
Full summary, score breakdown and related studies → Original source
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2003-11-01
Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam
47/100 ✓ Peer-reviewed How common it is Proceedings of the National Academy of Sciences of the United States of America
Key finding: Flying foxes are a prized food item of the indigenous Chamorro people who boil them in coconut cream and eat them whole. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-11-01
Predicting mortality among patients hospitalized for heart failure: derivation and validation of a clinical model
65/100 ✓ Peer-reviewed How common it is JAMA
Key finding: The mortality rates for the derivation cohort and validation cohort, respectively, were 8.9% and 8.2% in hospital, 10.7% and 10.4% at 30 days, and 32.9% and 30.5% at 1 year.
Full summary, score breakdown and related studies → Original source
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2003-11-01
Is caregiving hazardous to one's physical health? A meta-analysis
64/100 ✓ Peer-reviewed Caregiving Psychological bulletin
Key finding: The authors combined the results of 23 studies to compare the physical health of caregivers with demographically similar noncaregivers.
Full summary, score breakdown and related studies → Original source
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2003-11-01
Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI
54/100 ✓ Peer-reviewed Brain scans and imaging Diabetologia
Key finding: Type 2 diabetes is associated with hippocampal and amygdalar atrophy, regardless of vascular pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-11-01
Left/right asymmetry of atrophy in semantic dementia: behavioral-cognitive implications
53/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: Patients with left and right predominant SD present with distinct behavioral-cognitive profiles. +2 more findings
Full summary, score breakdown and related studies → Original source
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2003-11-01
Ginkgo biloba extract EGb 761 in dementia: intent-to-treat analyses of a 24-week, multi-center, double-blind, placebo-controlled, randomized trial
61/100 ✓ Peer-reviewed Treatments Pharmacopsychiatry
Key finding: The comparison of the results of this double-blind, placebo-controlled, randomized, multi-center study with other dementia studies is hampered by the fact that only the responder analysis of the per-protocol (PP) population, which was pre-specified in the protocol as confirmatory analysis, has been published in detail so far. +4 more findings
Full summary, score breakdown and related studies → Original source
October 2003 9
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2003-10-28
Very early onset AD with a de novo mutation in the presenilin 1 gene (Met 233 Leu)
46/100 ✓ Peer-reviewed Risk genes beyond APOE Neurology
Key finding: The authors describe a 28-year-old woman with histopathologically confirmed early onset Alzheimer disease characterized by severe frontal lobe involvement associated with a de novo mutation in the presenilin 1 gene (PSEN1).
Full summary, score breakdown and related studies → Original source
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2003-10-27
Inflammation is detrimental for neurogenesis in adult brain
52/100 ✓ Peer-reviewed Inflammation and the immune system Proceedings of the National Academy of Sciences of the United States of America
Key finding: Here, we demonstrate that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where the new neurons are born, strongly impairs basal hippocampal neurogenesis in rats. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-10-01
Environmental Correlates to Behavioral Health Outcomes in Alzheimer's Special Care Units
36/100 ✓ Peer-reviewed Clinical safety The Gerontologist
Key finding: We found associations between each behavioral health measure and particular environmental design features, as well as between behavioral health measures and both resident and nonenvironmental facility variables. +2 more findings
Full summary, score breakdown and related studies → Original source
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2003-10-01
The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg
36/100 ✓ Peer-reviewed Disease mechanisms Neuron
Key finding: Recent findings indicate that the system is involved in the pathogenesis of Parkinson's, Alzheimer's, Huntington's, and Prion diseases as well as amyotrophic lateral sclerosis.
Full summary, score breakdown and related studies → Original source
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2003-10-01
Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's disease
36/100 ✓ Peer-reviewed Genetics Brain research. Molecular brain research
Key finding: Two-dimensional gel electrophoresis (2-DE), SYPRO Ruby staining and mass spectrometry were used for clinical screening of disease-influenced CSF proteins in AD patients compared to controls. +1 more finding
Full summary, score breakdown and related studies → Original source
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2003-10-01
Quantifying mRNA in postmortem human brain: influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variance
36/100 ✓ Peer-reviewed Biomarkers Brain research. Molecular brain research
Key finding: Age at death had inconsistent but significant correlations to amounts of mRNA; male and female controls both had negative correlations, female AD a positive correlation and male AD no correlation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2003-10-01
Changes in hippocampal volume and shape across time distinguish dementia of the Alzheimer type from healthy aging
47/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage
Key finding: Hippocampal volume loss over time was significantly greater in the CDR 0.5 subjects (left = 8.3%, right = 10.2%) than in the CDR 0 subjects (left = 4.0%, right = 5.5%) (ANOVA, F = 7.81, P = 0.0078). +2 more findings
Full summary, score breakdown and related studies → Original source
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2003-10-01
Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder
47/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: These findings suggest that long-term treatment with paroxetine is associated with improvement of verbal declarative memory deficits and an increase in hippocampal volume in PTSD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2003-10-01
Longitudinal driving performance in early-stage dementia of the Alzheimer type
59/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society
Key finding: This study provides longitudinal evidence for a decline in driving performance over time, primarily in early-stage DAT, and supports the need not only for driving assessments, but also for reevaluation of individuals with very mild and mild DAT. +2 more findings
Full summary, score breakdown and related studies → Original source
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