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Macrophage subsets in atherosclerosis as defined by single-cell technologies
Willemsen L, de Winther MP.. The Journal of pathology, 2020-03-11
Topic: Brain proteins, microglia and lab models
Macrophages play a major role in the pathogenesis of atherosclerosis. Many studies have shone light on the different phenotypes and functions that macrophages can acquire upon exposure to local cues. The microenvironment of the atherosclerotic plaque contains a plethora of macrophage-controlling factors, such as cytokines, oxidised low-density lipoproteins and cell debris.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Willemsen, L., & de Winther, M. P. (2020). Macrophage subsets in atherosclerosis as defined by single-cell technologies. The Journal of pathology. https://doi.org/10.1002/path.5392
Vancouver
Willemsen L, de Winther MP. Macrophage subsets in atherosclerosis as defined by single-cell technologies. The Journal of pathology. 2020. doi:10.1002/path.5392. PMID: 32003464.
BibTeX
@article{willemsen2020-32003464,
author = {Willemsen, L. and de Winther, M. P.},
title = {{Macrophage subsets in atherosclerosis as defined by single-cell technologies}},
journal = {The Journal of pathology},
year = {2020},
doi = {10.1002/path.5392},
pmid = {32003464},
url = {https://doi.org/10.1002/path.5392}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Many studies have shone light on the different phenotypes and functions that macrophages can acquire upon exposure to local cues.
- The microenvironment of the atherosclerotic plaque contains a plethora of macrophage-controlling factors, such as cytokines, oxidised low-density lipoproteins and cell debris.
- Previous research has determined macrophage function within the plaque mainly by using immunohistochemistry and bulk analysis.
- The recent development and rapid progress of single-cell technologies, such as cytometry by time of flight and single-cell RNA sequencing, now enable comprehensive mapping of the wide range of cell types and their phenotypes present in atherosclerotic plaques.
Why it matters
This review concerns macrophage subsets in atherosclerosis, not Alzheimer's disease, so it gives no direct information about treating, curing or preventing Alzheimer's. It describes how single-cell technologies are being used to define macrophage phenotypes and functions within atherosclerotic plaques.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 51/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journal of pathology) |
| Journal's citation record | 3 / 4 | The Journal of Pathology: journal h-index 254 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 229 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 28.6 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 4 / 6 | Cited 10.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 3 / 4 | Cited 97 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Menno P.J. de Winther: h-index 73 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Ludwig-Maximilians-Universität München: institution h-index 1,224 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32003464) |
| Free to read | 2 / 2 | Free to read |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1002/path.5392
- PubMed: 32003464
- Original source →
- Free full text: The Journal of Pathology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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