Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,076–18,100 of 27,380 studies, newest first · page 724 of 1096.
February 2014 9
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2014-02-01
Cross-boundary Cancer Studies at the University of Tokyo: Food and Cancer
27/100 ✓ Peer-reviewed Risk factors Japanese Journal of Clinical Oncology
Key finding: He has been actively delivering lectures on the prevention of diseases associated with adult lifestyle habits and the preservation of the global environment via ‘shokuiku,’ or food education. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-01
Development and validation of a brief dementia screening indicator for primary care
57/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The final Dementia Screening Indicator included age (1 point/year; ages, 65-79 years), less than 12 years of education (9 points), stroke (6 points), diabetes mellitus (3 points), body mass index less than 18.5 kg/m(2) (8 points), requiring assistance with money or medications (10 points), and depressive symptoms (6 points). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-01
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations
55/100 ✓ Peer-reviewed Lewy body dementia Neuron
Key finding: TDP-43 is a major component of the cytoplasmic inclusions characteristic of amyotrophic lateral sclerosis and some types of frontotemporal lobar degeneration. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-01
The glutamatergic hypothesis for Down syndrome: the potential use of N-methyl-D-aspartate receptor antagonists to enhance cognition and decelerate neurodegeneration
34/100 ✓ Peer-reviewed Down syndrome and Alzheimer's CNS & neurological disorders drug targets
Key finding: Recent preclinical and clinical work on the N-methyl-D-aspartate (NMDA) receptor antagonist memantine give us some reason for optimism, at least in relation to the potential for a partial pharmacological improvement of hippocampus dependent memory deficits associated with DS. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-02-01
Phosphorylation of tau protein at sites Ser(396-404) is one of the earliest events in Alzheimer's disease and Down syndrome
44/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuropathology and applied neurobiology
Key finding: Phosphorylation of tau protein at the carboxyl terminus may be among the earliest tau events, and it occurs prior to the apparition of the classical fibrillar structure. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-02-01
Postoperative cognitive dysfunction
46/100 ✓ Peer-reviewed Getting a diagnosis Deutsches Arzteblatt international
Key finding: POCD can markedly impair postoperative recovery. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-01
Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease
48/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: A link between Alzheimer's disease (AD) and metabolic disorders has been established, with patients with type 2 diabetes at increased risk of developing AD and vice versa. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-02-01
Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial
82/100 ✓ Peer-reviewed Treatments JAMA
Key finding: Among patients with probable Alzheimer disease and agitation who were receiving psychosocial intervention, the addition of citalopram compared with placebo significantly reduced agitation and caregiver distress; however, cognitive and cardiac adverse effects of citalopram may limit its practical application at the dosage of 30 mg per day. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-02 month only
The Costs of Dementia From the Societal Perspective: Is Care Provided in the Community Really Cheaper Than Nursing Home Care?
52/100 ✓ Peer-reviewed Costs and economics Journal of the American Medical Directors Association
Key finding: Unadjusted annual societal costs were €29,930 (community) vs €33,482 (nursing home) per patient +3 more findings
Full summary, score breakdown and related studies → Original source
January 2014 16
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2014-01-30
Active immunotherapy options for Alzheimer's disease
40/100 ✓ Peer-reviewed Drug development Alzheimer's research & therapy
Key finding: AD pathogenesis is associated with the accumulation of amyloid-beta protein (Aβ) and/or hyperphosphorylated tau protein in the brain. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-30
Speech in Alzheimer's disease: can temporal and acoustic parameters discriminate dementia?
40/100 ✓ Peer-reviewed Digital health tools Dementia and geriatric cognitive disorders
Key finding: These measures offer a sensitive method of assessing spontaneous speech output in AD, and they discriminate well between people with AD and healthy older adults. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-01-29
Diabetes mellitus and the risk of Alzheimer's disease: a nationwide population-based study
59/100 ✓ Peer-reviewed Costs and economics PloS one
Key finding: Newly diagnosed DM was associated with increased risk of AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-29
Prevalence of cortical superficial siderosis in a memory clinic population
61/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Agreement for detection of SS was excellent (unweighted κ of 0.81). +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-01-29
Confidentiality in preclinical Alzheimer disease studies: when research and medical records meet
44/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: An individual enrolled in a research study that uses positive test results from amyloid PET imaging or CSF measures of β-amyloid 42 as inclusion criteria has biomarkers indicative of AD pathology. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-28
A claims data-based comparison of comorbidity in individuals with and without dementia
49/100 ✓ Peer-reviewed Prevention and risk BMC geriatrics
Key finding: Individuals with dementia were more likely to be diagnosed with 15 comorbidity complexes, including Parkinson's, stroke, diabetes, atherosclerosis (supposed dementia risk factors) or fluids and electrolyte disorders, insomnia, incontinence, pneumonia, fractures and injuries (supposed sequelae). +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-27
Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents
38/100 ✓ Peer-reviewed Drug development Journal of neuroscience research
Key finding: In the Y-maze test, LPS (10 μg/mouse, i.c.v) significantly decreased the percentage alternation. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-01-23
Family caregiver challenges in dementia care in Australia and China: a critical perspective
41/100 ✓ Peer-reviewed Caregiving BMC geriatrics
Key finding: In total 148 caregivers participated in the project with 57 of them from Australia (26 and 31 in the qualitative and quantitative strands respectively) and 91 of them from China (23 and 68 in the qualitative and quantitative strands respectively). +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-23
What is the current state of care for older people with dementia in general hospitals? A literature review
36/100 ✓ Peer-reviewed Costs and economics Dementia (London, England)
Key finding: Significantly, this review highlights that overall there remains mostly negative consequences and outcomes for people with dementia when they go into general hospitals. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-01-23
c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo
40/100 ✓ Peer-reviewed Disease mechanisms Cell death & disease
Key finding: We here characterized the pathways leading to synaptopathy in TgCRND8 mice and showed that c-Jun N-terminal kinase (JNK) is activated at the spine prior to the onset of cognitive impairment.
Full summary, score breakdown and related studies → Original source
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2014-01-22
Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study
66/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology
Key finding: A higher omega-3 index was correlated with larger total normal brain volume and hippocampal volume in postmenopausal women measured 8 years later. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-22
Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
62/100 ✓ Peer-reviewed Treatments New England Journal of Medicine
Solanezumab, a humanized monoclonal antibody that binds amyloid, failed to improve cognition or functional ability.
Full summary, score breakdown and related studies → Original source
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2014-01-22
APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory
49/100 ✓ Peer-reviewed Genetics Neurology
Key finding: The APOE ε4 allele segregated dose-dependently and selectively with CA1-SRLM thinning and worse episodic memory performance in a pool of older subjects across a cognitive spectrum. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-21
Barriers to advance care planning in cancer, heart failure and dementia patients: a focus group study on general practitioners' views and experiences
47/100 ✓ Peer-reviewed End-of-life care PloS one
Key finding: The results of our study contribute to a better understanding of the factors hindering GPs in initiating ACP. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-01-21
Grey matter changes in cognitively impaired Parkinson's disease patients
46/100 ✓ Peer-reviewed Brain scans and imaging PloS one
Key finding: Grey matter changes in PDD involve areas associated with Alzheimer-like pathology while fronto-parietal abnormalities are possibly an early marker of PD cognitive decline. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-20
Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice
47/100 ✓ Peer-reviewed Risk genes beyond APOE Scientific reports
Key finding: However, its pathogenesis remains largely to be determined. +3 more findings
Full summary, score breakdown and related studies → Original source
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