Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 476–500 of 27,380 studies, newest first · page 20 of 1096.
September 2026 25
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2026-09-13
Feasibility, Safety, and Preliminary Efficacy of Partnered Rhythmic Rehabilitation in Prodromal Alzheimer's Disease: A 12-Month Pilot Randomized Controlled Trial
16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv (preprint)
Key finding: This study evaluated the feasibility, safety, and preliminary efficacy of PRR compared to group walking (WALK) in adults with pAD and amnestic mild cognitive impairment (aMCI). +4 more findings
Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-12
Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants
16/100 ⚠ Preprint — not yet peer-reviewed How common it is bioRxiv
Key finding: However, APOE4 is neither necessary nor sufficient to cause disease, suggesting that additional genetic and environmental factors contribute to AD pathogenesis. +4 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
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2026-09-12
Soluble pathogenic tau transmission to astrocytes drives cellular senescence and neurovascular uncoupling in a model of Alzheimer’s tauopathy
16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv
Key finding: We previously demonstrated that soluble tau aggregates accumulate in brain microvascular endothelial cells, inducing cellular senescence and microvascular dysfunction in a mouse model of tauopathy. +1 more finding
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
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2026-09-12
Clonal Haematopoiesis Tracks Alzheimer's-like Cortical Atrophy in Community-Dwelling Older Adults
16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv (preprint)
Key finding: BackgroundClonal haematopoiesis (CH), the age-related expansion of mutated blood stem cells, is detectable in around 10% of people in their seventies, rises steeply with age, and is associated with several diseases. +4 more findings
Scored 38 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-12
A National Survey Exploring Dementia Diagnostics and Care Provisions in Primary Care in England
16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)
Key finding: Disease Modifying Treatments (DMTs) and biomarker tests for dementia will likely be introduced, with potentially significant impacts on community care, particularly general practice.
Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-12
Detection and Continuous Monitoring of Memory Dysfunction in Mild Cognitive Impairment and Healthy Aging Through Adaptive Computational Phenotyping
16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv (preprint)
Key finding: These findings show that model-based, adaptive assessments can support high-frequency, remote detection and scalable longitudinal monitoring of early memory decline, providing a new way to assess memory decline trajectories in healthy aging and dementia. +2 more findings
Scored 44 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
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2026-09-11
Tissue- and compartment-resolved brain age reveals vascular-metabolic and neurodegenerative aging
16/100 ⚠ Preprint — not yet peer-reviewed Long-term cohort studies Research Square
Key finding: Emerging evidence suggests that subtle “dirty-appearing” T2-FLAIR abnormalities may mark diffuse white matter (WM) vulnerability that precedes or extends beyond overt WM hyperintensities (WMH). +2 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-11
Gender bias in the diagnosis of Alzheimer's Disease
16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment Research Square
Key finding: These findings demonstrate that fairness-aware ML can reduce sex-related bias in AD classification without loss of performance and improve interpretability through more balanced representation of disease determinants.
Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
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2026-09-11
Selective vulnerability and resilience of thalamic neuronal populations in Frontotemporal Dementia
16/100 ⚠ Preprint — not yet peer-reviewed Lewy body dementia Research Square
Key finding: Frontotemporal dementia (FTD) caused by progranulin (GRN) mutations is associated with pronounced thalamic degeneration, yet the cellular basis of selective thalamic vulnerability remains poorly understood. +2 more findings
Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
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2026-09-11
Vocal acoustic biomarkers predict amyloid positivity in non-demented individuals
16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools Research Square
Key finding: These results indicate that high-load motor speech can reveal subtle neuro-motor changes associated with early Alzheimer's pathology, supporting vocal acoustic markers as a sensitive, low-burden complement to established biomarkers.
Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
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2026-09-11
Biocatalytic Production of Galantamine in Yeast through Cytochrome P450 Optimization
16/100 ⚠ Preprint — not yet peer-reviewed Treatments bioRxiv
Key finding: Heterologous expression of the downstream pathway enzymes NtCYP96T6, NtNMT1, and NtAKR1 from Narcissus cv. +4 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-11
Brain-resident myeloid cells promote rapid leukocyte adhesion in leptomeningeal vessels after anti-Aβ immunotherapy
16/100 ⚠ Preprint — not yet peer-reviewed Treatments bioRxiv
Key finding: Anti-amyloid-β (Aβ) immunotherapy improves cognitive outcomes in Alzheimer’s disease (AD) but is associated with amyloid-related imaging abnormalities (ARIA), through poorly understood mechanisms. +2 more findings
Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
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2026-09-11
Cryo-ET and Sub-Volume Analysis of Fibrillar Pathology in the Neurodegenerative Human Brain
16/100 ⚠ Preprint — not yet peer-reviewed Treatments bioRxiv
Key finding: Subtomogram averaging and helical reconstruction of fibril subvolumes yielded low-resolution (∼30-35Å) density maps, which were compared to existing ex vivo structures.
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-11
High frame rate in vivo two-photon microscopy to quantify murine cerebrospinal fluid flow heterogeneity
16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers bioRxiv
Key finding: Together, these results establish CSF pulsatility as a measurable signature of network-scale CSF dynamics.
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-11
Amyloid-Independent Elevation of Plasma phosphorylated tau-217 Tracks Neurodegenerative Risk in Tuberous Sclerosis Complex: Implications for mTOR-Targeted Intervention
16/100 ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)
Key finding: ResultsFindings revealed elevated levels of plasma ptau-217 in individuals with TSC at younger ages with a parallel age-related trajectory between TSC, AD, and CU cohorts. +4 more findings
Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-11
Context Matters in LLM-Assisted Qualitative Data Analysis: Workflow Development and Multidimensional Evaluation in Health Research
16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology medRxiv (preprint)
Key finding: Qwen-output showed the most consistently favourable overall profile, while Claude-output was most often ranked first in individual domain-dimension evaluations.
Scored 23 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
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2026-09-11
Data-driven subtypes of Alzheimer's Disease: A multicohort study
16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv (preprint)
Key finding: Accordingly, the atrophy-first subtype carried a higher risk of conversion to AD than the WMH-first group.
Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-11
Drug-Drug Interaction Signals Between Anti-Amyloid-β Antibodies and Antithrombotic Drugs for Amyloid-Related Imaging Abnormalities and Intracranial Hemorrhage: A FAERS Disproportionality Analysis
16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv (preprint)
Key finding: BackgroundAnti-amyloid-{beta} (A{beta}) monoclonal antibodies are disease-modifying treatments for early Alzheimers disease but are associated with amyloid-related imaging abnormalities (ARIA) and intracranial hemorrhage (ICH). +1 more finding
Scored 18 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-11
Multi-trait Polygenic Profiling and Survival Free of Dementia and Disability: Results from the Health and Retirement Study
16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)
Key finding: ObjectiveTo determine whether a multi-trait polygenic profile for dementia is associated with dementia- and disability-free survival in middle-aged and older adults. +4 more findings
Scored 38 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-11
Vascular and neurodegenerative contributions to cognitive decline and multidomain progression in de novo Parkinsons disease
16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv (preprint)
Key finding: Greater baseline WMH burden was associated with differential longitudinal progression in converters across eleven clinical outcomes, including cognition, gait, and functional independence (all q<0.05). +1 more finding
Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-11
Panorama clínico e epidemiológico da doença de Alzheimer no Brasil: desafios atuais e perspectivas
27/100 ✓ Peer-reviewed Genetics Contribuciones a las Ciencias Sociales
Key finding: Destaca-se também a APOE (Apolipoproteína E) um gene que codifica uma proteína essencial no metabolismo lipídico e no transporte de colesterol no sistema nervoso central. +4 more findings
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2026-09-11
Anti-Amyloid Monoclonal Antibodies in Early Alzheimer Disease: Lecanemab and Donanemab
47/100 ✓ Peer-reviewed Genetics Neurology International
Key finding: Pivotal trials demonstrated statistically significant but modest average slowing of decline: Clarity AD showed a 0.45-point between-group difference in CDR-SB worsening at 18 months, and TRAILBLAZER-ALZ 2 showed a 3.25-point iADRS difference in the low/medium-tau population at 76 weeks. +4 more findings
Full summary, score breakdown and related studies → Original source
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2026-09-10
Genetic Characterization of MAPT Exon 6 Variants in Indonesian Patients with Vascular Dementia: A Cross-Sectional Sequencing Study
59/100 ✓ Peer-reviewed Cognitive tests and assessment F1000Res
Key finding: This study provides the first molecular characterization of MAPT gene variants in Indonesian patients with vascular dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2026-09-10
Stage-dependent indirect association between mobility and the cognition-ADL relationship: a cross-sectional study of older adults across the cognitive continuum
16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment Research Square
Key finding: In this cross-sectional sample, mobility showed a progressively stronger statistical indirect association with the cognition-ADL relationship as cognitive impairment deepened. +2 more findings
Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2026-09-10
Comparative Analysis of Individual Graph Construction Methods from Static FDG-PET Images: an ADNI study in Alzheimer’s Disease Subjects
16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment Research Square
Key finding: Our findings indicate that all methods captured AD disconnection patterns but exhibited variability in preserving connectivity profiles, which seemed non-random but rather systematically linked to clinical measures and predictive power for AD classification. +4 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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