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Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States: A federated electronic medical record analysis
Harrison SL, Fazio-Eynullayeva E, Lane DA, Underhill P, Lip GYH.. PLoS medicine, 2020-09-10
Topic: Risk, prevention and care in population studies
Background At the beginning of June 2020, there were nearly 7 million reported cases of coronavirus disease 2019 (COVID-19) worldwide and over 400,000 deaths in people with COVID-19. The objective of this study was to determine associations between comorbidities listed in the Charlson comorbidity index and mortality among patients in the United States with COVID-19. Methods and findings A retrospective cohort study of adults with COVID-19 from 24 healthcare organizations in the US was conducted. The study included adults aged 18-90 years with COVID-19 coded in their electronic medical records between January 20, 2020, and May 26, 2020. Results were also stratified by age groups ( Conclusions Identifying patient characteristics and conditions associated with mortality with COVID-19 is important for hypothesis generating for clinical trials and to develop targeted intervention strategies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Harrison, S. L., Fazio-Eynullayeva, E., Lane, D. A., Underhill, P., & Lip, G. Y. H. (2020). Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States: A federated electronic medical record analysis. PLoS medicine. https://doi.org/10.1371/journal.pmed.1003321
Vancouver
Harrison SL, Fazio-Eynullayeva E, Lane DA, Underhill P, Lip GYH. Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States: A federated electronic medical record analysis. PLoS medicine. 2020. doi:10.1371/journal.pmed.1003321. PMID: 32911500.
BibTeX
@article{harrison2020-32911500,
author = {Harrison, S. L. and Fazio-Eynullayeva, E. and Lane, D. A. and Underhill, P. and Lip, G. Y. H.},
title = {{Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States: A federated electronic medical record analysis}},
journal = {PLoS medicine},
year = {2020},
doi = {10.1371/journal.pmed.1003321},
pmid = {32911500},
url = {https://doi.org/10.1371/journal.pmed.1003321}
}
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Key findings
- Results were also stratified by age groups ( Conclusions Identifying patient characteristics and conditions associated with mortality with COVID-19 is important for hypothesis generating for clinical trials and to develop targeted intervention strategies.
Why it matters
This study examined which other medical conditions were linked to death in adults with COVID-19. It does not address Alzheimer's disease treatment, cure or prevention.
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Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 62/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (PLoS medicine) |
| Journal's citation record | 3 / 4 | PLoS Medicine: journal h-index 350 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 419 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 52.4 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 4 / 6 | Cited 10.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 3 / 4 | Cited 61 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Gregory Y.H. Lip: h-index 212 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Liverpool: institution h-index 995 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32911500) |
| Free to read | 2 / 2 | Free to read |
| Total | 62 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1371/journal.pmed.1003321
- PubMed: 32911500
- Original source →
- Free full text: PLoS Medicine →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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