Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 9,801–9,825 of 27,380 studies, newest first · page 393 of 1096.
September 2021 25
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2021-09-14
Exploring Memory Care Clinics in Minnesota: A Qualitative Analysis
41/100 ✓ Peer-reviewed Health systems and care delivery Journal of geriatric psychiatry and neurology
Key finding: We identified 6 themes regarding financial issues, staffing, appointment logistics, care provision during and after the memory evaluation as well as features of an ideal clinic. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-14
Identification of Faecalibacterium prausnitzii strains for gut microbiome-based intervention in Alzheimer's-type dementia
41/100 ✓ Peer-reviewed Disease mechanisms Cell reports. Medicine
Key finding: We find that Faecalibacterium prausnitzii (F. prausnitzii) correlates with cognitive scores and decreases in the MCI group compared with the healthy group. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-14
NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING
41/100 ✓ Peer-reviewed Inflammation and the immune system Proceedings of the National Academy of Sciences of the United States of America
Key finding: Activation of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) are associated with DNA damage and senescence. cGAS-STING elevation was observed in the AD mice and normalized by NR treatment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-14
Intrinsic capacity and its associations with incident dependence and mortality in 10/66 Dementia Research Group studies in Latin America, India, and China: A population-based cohort study
67/100 ✓ Peer-reviewed Disparities PLoS medicine
Key finding: We aimed to inform planning by assessing intrinsic capacity prevalence, by characterising the target group, and by validating the general approach-testing hypotheses that DIC was consistently associated with higher risks of incident dependence and death. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-13
Digital Endpoints: Definition, Benefits, and Current Barriers in Accelerating Development and Adoption
43/100 ✓ Peer-reviewed Cognitive tests and assessment Digital Biomarkers
Key finding: We conclude with an interdependent list of challenges that must be collaboratively addressed before these endpoints are widely adopted.
Full summary, score breakdown and related studies → Original source
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2021-09-13
Effects of air pollution on dementia over Europe for present and future climate change scenarios
45/100 ✓ Peer-reviewed Risk factors Environmental research
Key finding: In this sense, this contribution evaluates the incidence of dementia (Alzheimer's disease, AD, and dementia from unspecified cause, DU) occurring in Europe associated with the exposure to air pollution (essentially NO2 and PM2.5) for the present climatic period (1991-2010) and for a future climate change scenario (RCP8.5, 2031-2050). +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-09-13
Understanding insomnia as systemic disease
41/100 ✓ Peer-reviewed Risk factors Yeungnam University journal of medicine
Key finding: However, a high proportion of patients with insomnia do not seek treatment, which results in high direct and indirect costs.
Full summary, score breakdown and related studies → Original source
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2021-09-13
Epigenetic Age Acceleration and Cognitive Decline: A Twin Study
64/100 ✓ Peer-reviewed Genetics The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: In cross-sectional analyses at baseline, there was no association between DNAm age acceleration and cognitive function scores. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-13
Associations of ophthalmic and systemic conditions with incident dementia in the UK Biobank
48/100 ✓ Peer-reviewed Long-term cohort studies The British journal of ophthalmology
Key finding: Our analysis included 12 364 adults aged 55-73 years from the UK Biobank cohort. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-12
Ocular Neurodegenerative Diseases: Interconnection between Retina and Cortical Areas
41/100 ✓ Peer-reviewed Brain scans and imaging Cells
Key finding: Furthermore, several studies have shown that also ocular disorders present characteristics of neurodegenerative diseases and, on the other hand, CNS pathologies, i.e., Alzheimer disease (AD) and Parkinson disease (PD), which are causes of morbidity and mortality worldwide, show peculiar alterations at the ocular level.
Full summary, score breakdown and related studies → Original source
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2021-09-11
Depression, cognitive reserve markers, and dementia risk in the general population
52/100 ✓ Peer-reviewed Risk factors Aging & mental health
Key finding: Baseline depression and low cognitive reserve significantly increased the risk of subsequent dementia at follow-up. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-11
Effectiveness of the 10 cm2 Rivastigmine Patch in Taiwanese Patients with Mild-to-Moderate Alzheimer's Dementia: A 48-Week Real-World Observational Study
34/100 ✓ Peer-reviewed Health systems and care delivery Advances in therapy
Key finding: The primary endpoint was the change in the cognitive assessment screening instrument (CASI) scores at Week 48 versus baseline. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-11
Relationships between physical activity, sleep and cognitive function: A narrative review
52/100 ✓ Peer-reviewed Prevention and risk Neuroscience and biobehavioral reviews
Key finding: Other lifestyle factors, including sleep, are associated with cognitive function and dementia risk, and exercise is an effective therapeutic strategy for improving sleep. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-10
Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors
41/100 ✓ Peer-reviewed Vascular contributions Frontiers in aging neuroscience
Key finding: VaD regroups heterogeneous neurological conditions in which the decline of cognitive functions, including executive functions, is associated with structural and functional alterations in the cerebral vasculature. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-10
Ophthalmic Biomarkers for Alzheimer's Disease: A Review
41/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in aging neuroscience
Key finding: Over recent years, significant advances have been made in using ocular biomarkers to diagnose various neurodegenerative diseases, including AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-09-10
ApoE4 increases susceptibility to stress-induced age-dependent depression-like behavior and cognitive impairment
41/100 ✓ Peer-reviewed Genetics Journal of psychiatric research
Key finding: The results showed that 8-month apoE4-TR mice were more susceptible to the CUMS-induced depression-like behaviors and cognitive impairment than age-matched apoE3-TR mice.
Full summary, score breakdown and related studies → Original source
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2021-09-09
Synaptic tau: A pathological or physiological phenomenon?
41/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica communications
Key finding: Alongside synaptic pathology, recent data suggest that Tau has physiological roles in the pre- or post- synaptic compartments.
Full summary, score breakdown and related studies → Original source
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2021-09-09
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
41/100 ✓ Peer-reviewed Brain tissue and pathology Molecular neurodegeneration
Key finding: Immunohistochemical analysis of M20/L85 mice revealed that pre-existing Aβ plaques exacerbate the spread and deposition of induced α-synuclein pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-09
Cerebral Amyloid Angiopathy Pathology and Its Association With Amyloid-β PET Signal
45/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: Forty-one participants (30 male, 11 female) with a mean (SD) age at death of 75.7 (10.6) years were included. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-09-09
Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET
63/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: Amyloid accumulation was evaluated in 236 individuals who underwent >1 amyloid PET scan.
Full summary, score breakdown and related studies → Original source
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2021-09-08
Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease
59/100 ✓ Peer-reviewed Hippocampus size on brain scans Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: These findings highlight the diagnostic and longitudinal monitoring potential of GFAP and p-tau for preclinical AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-08
Mental and neurological disorders and risk of COVID-19 susceptibility, illness severity and mortality: A systematic review, meta-analysis and call for action
79/100 ✓ Peer-reviewed Clinical safety EClinicalMedicine
Key finding: Overall, mental and neurological disorders were associated with a significant high risk of infection (pre-existing mental: OR 1·67, 95% CI 1·12-2·49; and pre-existing neurological: 2·05, 1·58-2·67), illness severity (mental: pre-existing, 1·40, 1·25-1·57; sequelae, 4·85, 2·53-9·32; neurological: pre-existing, 1·43, 1·09-1·88; sequelae, 2·17, 1·45-3·24), and mortality (mental: pre-existing, 1·47, 1·26-1·72; neurological: pre-existing, 2·08, 1·61-2·69; sequelae, 2·03, 1·66-2·49) from COVID-19. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-08
Machine-learning-based COVID-19 mortality prediction model and identification of patients at low and high risk of dying
55/100 ✓ Peer-reviewed Digital health tools Critical care (London, England)
Key finding: An accurate COVID-19 mortality prediction model among hospitalized patients based on the clinical features and comorbidities may play a beneficial role in the clinical setting to better management of patients with COVID-19. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-07
Exercise Dose and Aerobic Fitness Response in Alzheimer's Dementia: Findings from the FIT-AD Trial
79/100 ✓ Peer-reviewed Prevention trials International journal of sports medicine
Key finding: The aerobic exercise group significantly increased peak oxygen consumption (1.28 ml/kg/min; p=0.03) in subgroup who achieved maximal criteria on cardiopulmonary exercise test. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-09-07
Scoping review: the empowerment of Alzheimer's Disease caregivers with mHealth applications
43/100 ✓ Peer-reviewed Cognitive tests and assessment NPJ digital medicine
Key finding: The review revealed that mHealth applications for AD patients' caregivers are inadequate.
Full summary, score breakdown and related studies → Original source
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