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Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model
Wang Y, Shi Y, Huang Y, Liu W, Cai G, Huang S, Zeng Y, Ren S et al.. Journal of neuroinflammation, 2020-10-21
Topic: Brain proteins, microglia and lab models
Background Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. Resveratrol has shown neuroprotection by inhibiting inflammatory response in NeuP. Recently, the triggering receptor expressed on myeloid cells 2 (TREM2) expressed by microglia was identified as a critical factor of inflammation in nervous system diseases.
Key findings
- Resveratrol has shown neuroprotection by inhibiting inflammatory response in NeuP.
- Recently, the triggering receptor expressed on myeloid cells 2 (TREM2) expressed by microglia was identified as a critical factor of inflammation in nervous system diseases.
- In this study, we explored whether resveratrol could ameliorate neuroinflammation and produce anti-mechanical allodynia effects via regulating TREM2 in spared nerve injury rats, as well as investigated the underlying mechanisms.
- Methods A spared nerve injury (SNI) rat model was performed to investigate whether resveratrol could exert anti-mechanical allodynia effects via inhibiting neuroinflammation.
Why it matters
This rat study explored whether resveratrol ameliorates neuroinflammation and produces anti-mechanical allodynia effects via regulating TREM2 in spared nerve injury. It concerns neuropathic pain in rats and does not report any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuroinflammation) |
| Journal's citation record | 2 / 4 | Journal of Neuroinflammation: journal h-index 216 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “rat”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 81 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.1 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 5.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 41 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Wen Wu: h-index 25 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Shenzhen University: institution h-index 530 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33081801) |
| Free to read | 2 / 2 | Free to read |
| Total | 43 / 100 | — |
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Read the original
- DOI: 10.1186/s12974-020-01991-2
- PubMed: 33081801
- Original source →
- Free full text: Journal of Neuroinflammation →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Wang, Y., Shi, Y., Huang, Y., Liu, W., Cai, G., Huang, S., et al. (2020). Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model. Journal of neuroinflammation. https://doi.org/10.1186/s12974-020-01991-2
Vancouver
Wang Y, Shi Y, Huang Y, Liu W, Cai G, Huang S, et al. Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model. Journal of neuroinflammation. 2020. doi:10.1186/s12974-020-01991-2. PMID: 33081801.
BibTeX
@article{wang2020-33081801,
author = {Wang, Y. and Shi, Y. and Huang, Y. and Liu, W. and Cai, G. and Huang, S. and Zeng, Y. and Ren, S. and others},
title = {{Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model}},
journal = {Journal of neuroinflammation},
year = {2020},
doi = {10.1186/s12974-020-01991-2},
pmid = {33081801},
url = {https://doi.org/10.1186/s12974-020-01991-2}
}
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