Home › Research › Brain scans and imaging
Ganglion Cell Layer Thinning in Alzheimer's Disease
Alicia López-de-Eguileta, Andrea Cerveró, Ainara Ruiz de Sabando, Pascual Sánchez-Juan, Alfonso Casado. Medicina (Kaunas, Lithuania), 2020-10-21
Topic: Plasma and spinal-fluid biomarkers
The main advantages of optical retinal imaging may allow researchers to achieve deeper analysis of retinal ganglion cells (GC) in vivo using optical coherence tomography (OCT). Using this device to elucidate the impact of Alzheimer's disease (AD) on retinal health with the aim to identify a new AD biomarker, a large amount of studies has analyzed GC in different stages of the disease. Our review highlights recent knowledge into measuring retinal morphology in AD making distinctive between whether those studies included patients with clinical dementia stage or also mild cognitive impairment (MCI), which selection criteria were applied to diagnosed patients included, and which device of OCT was employed. Despite several differences, previous works found a significant thinning of GC layer in patients with AD and MCI. In the long term, an important future direction is to achieve a specific ocular biomarker with enough sensitivity to reveal preclinical AD disorder and to monitor progression.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
López-de-Eguileta, A., Cerveró, A., de Sabando, A. R., Sánchez-Juan, P., & Casado, A. (2020). Ganglion Cell Layer Thinning in Alzheimer's Disease. Medicina (Kaunas, Lithuania). https://doi.org/10.3390/medicina56100553
Vancouver
López-de-Eguileta A, Cerveró A, de Sabando AR, Sánchez-Juan P, Casado A. Ganglion Cell Layer Thinning in Alzheimer's Disease. Medicina (Kaunas, Lithuania). 2020. doi:10.3390/medicina56100553. PMID: 33096909.
BibTeX
@article{lopezdeeguileta2020-33096909,
author = {López-de-Eguileta, Alicia and Cerveró, Andrea and de Sabando, Ainara Ruiz and Sánchez-Juan, Pascual and Casado, Alfonso},
title = {{Ganglion Cell Layer Thinning in Alzheimer's Disease}},
journal = {Medicina (Kaunas, Lithuania)},
year = {2020},
doi = {10.3390/medicina56100553},
pmid = {33096909},
url = {https://doi.org/10.3390/medicina56100553}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Despite several differences, previous works found a significant thinning of GC layer in patients with AD and MCI.
New to this subject? Start with our plain-English guide: Brain scans & tests →
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Medicina (Kaunas, Lithuania)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33096909) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Related
Studies in the library that share something with this one. The line above each title says what.
Related studies in Brain scans and imaging
Also tagged “optical”
151 studies in the library carry the topic tag “optical”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 151 tagged studies.