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Age- and Sex-Specific Prevalence and Modifiable Risk Factors of Mild Cognitive Impairment Among Older Adults in China: A Population-Based Observational Study
Jingzhu Fu, Qian Liu, Yue Jennifer Du, Yun Zhu, Changqing Sun, Hongyan Lin, Mengdi Jin, Fei Ma et al.. Frontiers in Aging Neuroscience, 2020-10-30
Topic: Risk, prevention and care in population studies
The mean (SD) age of the 4,631 participants was 67.6 (4.89) years, and 2579 (55.7%) were women. The overall age- and sex-standardized prevalence of MCI in our study population was 10.7%. There were significant associations of MCI with age (65-69 vs. 60-64 years, OR=0.74; 95% confidence interval (CI): 0.58, 0.96), physical activity (PA) (≥23.0 vs. < 23.0 MET- hours/week, OR=0.79; 95% CI: 0.64, 0.96), body mass index (BMI) (OR=0.92; 95% CI: 0.89, 0.95), grip strength (GS) (OR=0.50; 95% CI: 0.38, 0.67), hypertension (yes vs. no, OR=1.44; 95% CI: 1.18, 1.77), sleepy state (OR=1.80; 95% CI: 1.36, 2.37), longer sleep duration (OR=1.40; 95% CI: 1.14, 1.72). The inverse association between BMI and MCI was stronger in older age groups (P for heterogeneity=0.003). The age- and sex-standardized prevalence of MCI was 10.7% in the study area. PA, BMI, GS, sleepy state, sleep duration and hypertension were associated with MCI. Additionally, TG and BMI might have different effects on the presence of MCI at different sex and age stages, respectively.
Key findings
- The mean (SD) age of the 4,631 participants was 67.6 (4.89) years, and 2579 (55.7%) were women.
- The overall age- and sex-standardized prevalence of MCI in our study population was 10.7%.
- There were significant associations of MCI with age (65-69 vs. 60-64 years, OR=0.74; 95% confidence interval (CI): 0.58, 0.96), physical activity (PA) (≥23.0 vs. < 23.0 MET- hours/week, OR=0.79; 95% CI: 0.64, 0.96), body mass index (BMI) (OR=0.92; 95% CI: 0.89, 0.95), grip strength (GS) (OR=0.50; 95% CI: 0.38, 0.67), hypertension (yes vs. no, OR=1.44; 95% CI: 1.18, 1.77), sleepy state (OR=1.80; 95% CI: 1.36, 2.37), longer sleep duration (OR=1.40; 95% CI: 1.14, 1.72).
- The inverse association between BMI and MCI was stronger in older age groups (P for heterogeneity=0.003).
- The age- and sex-standardized prevalence of MCI was 10.7% in the study area.
Why it matters
This study found that several factors, including physical activity, body mass index, grip strength, and hypertension, were associated with mild cognitive impairment in older adults in China. These are associations only and do not prove that modifying these factors can prevent or treat Alzheimer's disease.
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Study details
- Study designcross-sectional
- Participants4,943
- Effect size55.7%; 10.7%; OR=0.74
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in Aging Neuroscience) |
| Journal's citation record | 2 / 4 | Frontiers in Aging Neuroscience: journal h-index 174 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 3 / 4 | 4,943 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 35 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.4 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 2 / 6 | Cited 2.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 18 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Guowei Huang: h-index 45 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Tianjin Medical University: institution h-index 402 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33192471) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
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Read the original
- DOI: 10.3389/fnagi.2020.578742
- PubMed: 33192471
- Original source →
- Free full text: Frontiers in Aging Neuroscience →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Fu, J., Liu, Q., Du, Y. J., Zhu, Y., Sun, C., Lin, H., et al. (2020). Age- and Sex-Specific Prevalence and Modifiable Risk Factors of Mild Cognitive Impairment Among Older Adults in China: A Population-Based Observational Study. Frontiers in Aging Neuroscience. https://doi.org/10.3389/fnagi.2020.578742
Vancouver
Fu J, Liu Q, Du YJ, Zhu Y, Sun C, Lin H, et al. Age- and Sex-Specific Prevalence and Modifiable Risk Factors of Mild Cognitive Impairment Among Older Adults in China: A Population-Based Observational Study. Frontiers in Aging Neuroscience. 2020. doi:10.3389/fnagi.2020.578742. PMID: 33192471.
BibTeX
@article{fu2020-33192471,
author = {Fu, Jingzhu and Liu, Qian and Du, Yue Jennifer and Zhu, Yun and Sun, Changqing and Lin, Hongyan and Jin, Mengdi and Ma, Fei and others},
title = {{Age- and Sex-Specific Prevalence and Modifiable Risk Factors of Mild Cognitive Impairment Among Older Adults in China: A Population-Based Observational Study}},
journal = {Frontiers in Aging Neuroscience},
year = {2020},
doi = {10.3389/fnagi.2020.578742},
pmid = {33192471},
url = {https://doi.org/10.3389/fnagi.2020.578742}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.