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Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study
Zhou J, Liu C, Sun Y, Huang W, Ye K.. Brain, behavior, and immunity, 2020-10-24
Topic: Risk, prevention and care in population studies
Introduction Our understanding of risk factors for COVID‑19, including pre-existing medical conditions and genetic variations, is limited. To what extent the pre-existing clinical condition and genetic background have implications for COVID-19 still needs to be explored. Methods Our study included 389,620 participants of European descent from the UK Biobank, of whom 3,884 received the COVID-19 test and 1,091 were tested positive for COVID-19.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhou, J., Liu, C., Sun, Y., Huang, W., & Ye, K. (2021). Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study. Brain, behavior, and immunity. https://doi.org/10.1016/j.bbi.2020.10.019
Vancouver
Zhou J, Liu C, Sun Y, Huang W, Ye K. Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study. Brain, behavior, and immunity. 2021. doi:10.1016/j.bbi.2020.10.019. PMID: 33148439.
BibTeX
@article{zhou2021-33148439,
author = {Zhou, J. and Liu, C. and Sun, Y. and Huang, W. and Ye, K.},
title = {{Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study}},
journal = {Brain, behavior, and immunity},
year = {2021},
doi = {10.1016/j.bbi.2020.10.019},
pmid = {33148439},
url = {https://doi.org/10.1016/j.bbi.2020.10.019}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- To what extent the pre-existing clinical condition and genetic background have implications for COVID-19 still needs to be explored.
- Methods Our study included 389,620 participants of European descent from the UK Biobank, of whom 3,884 received the COVID-19 test and 1,091 were tested positive for COVID-19.
- We examined the association of COVID-19 status with an extensive list of 974 medical conditions and 30 blood biomarkers.
- Additionally, we tested the association of genetic variants in two key genes related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2), with COVID-19 or any other phenotypes.
Why it matters
This observational study examined whether pre-existing medical conditions and genetic factors are linked to COVID-19 status, including cognitive disorders. It does not show that preventing or treating COVID-19 prevents or treats Alzheimer's disease.
Study details
- Participants389,620
- Effect sizeOR = 2.29; OR = 2.16; OR = 1.90
- Evidence strengthLow
How this study scored 55/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain, behavior, and immunity) |
| Journal's citation record | 2 / 4 | Brain Behavior and Immunity: journal h-index 249 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 4 / 4 | 389,620 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 63 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.0 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 2 / 6 | Cited 1.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 2 / 4 | Cited 15 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Kaixiong Ye: h-index 26 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Cornell University: institution h-index 1,649 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33148439) |
| Free to read | 2 / 2 | Free to read |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.bbi.2020.10.019
- PubMed: 33148439
- Original source →
- Free full text: Brain Behavior and Immunity →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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