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Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults
Li P, Gao L, Gaba A, Yu L, Cui L, Fan W, Lim ASP, Bennett DA et al.. The lancet. Healthy longevity, 2020-11-12
Topic: Amyloid, tau and blood-test diagnosis
We used Cox proportional hazards models and logistic regressions to assess whether circadian disturbances predict an increased risk of incident Alzheimer's dementia and conversion of mild cognitive impairment to Alzheimer's dementia. In participants with mild cognitive impairment, increased risk of Alzheimer's dementia was predicted by lower amplitude (1 SD decrease, HR 1·46, 95% CI 1·24-1·72), higher intradaily variability (1 SD increase, 1·36, 1·15-1·60), and lower interdaily stability (1 SD decrease, 1·21, 1·02-1·44). Interpretation Our results indicate a link between circadian dysregulation and Alzheimer's progression, implying either a bidirectional relation or shared common underlying pathophysiological mechanisms.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Li, P., Gao, L., Gaba, A., Yu, L., Cui, L., Fan, W., et al. (2020). Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults. The lancet. Healthy longevity. https://doi.org/10.1016/s2666-7568(20)30015-5
Vancouver
Li P, Gao L, Gaba A, Yu L, Cui L, Fan W, et al. Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults. The lancet. Healthy longevity. 2020. doi:10.1016/s2666-7568(20)30015-5. PMID: 34179863.
BibTeX
@article{li2020-34179863,
author = {Li, P. and Gao, L. and Gaba, A. and Yu, L. and Cui, L. and Fan, W. and Lim, A. S. P. and Bennett, D. A. and others},
title = {{Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults}},
journal = {The lancet. Healthy longevity},
year = {2020},
doi = {10.1016/s2666-7568(20)30015-5},
pmid = {34179863},
url = {https://doi.org/10.1016/s2666-7568(20)30015-5}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- We used Cox proportional hazards models and logistic regressions to assess whether circadian disturbances predict an increased risk of incident Alzheimer's dementia and conversion of mild cognitive impairment to Alzheimer's dementia.
- In participants with mild cognitive impairment, increased risk of Alzheimer's dementia was predicted by lower amplitude (1 SD decrease, HR 1·46, 95% CI 1·24-1·72), higher intradaily variability (1 SD increase, 1·36, 1·15-1·60), and lower interdaily stability (1 SD decrease, 1·21, 1·02-1·44).
- Interpretation Our results indicate a link between circadian dysregulation and Alzheimer's progression, implying either a bidirectional relation or shared common underlying pathophysiological mechanisms.
Why it matters
In participants with mild cognitive impairment, increased risk of Alzheimer's dementia was predicted by lower circadian amplitude, higher intradaily variability and lower interdaily stability. The authors say the results indicate a link between circadian dysregulation and Alzheimer's progression, implying either a bidirectional relation or shared common underlying pathophysiological mechanisms.
Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 62/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The lancet. Healthy longevity) |
| Journal's citation record | 1 / 4 | The Lancet Healthy Longevity: journal h-index 78 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 171 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 21.4 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 4 / 6 | Cited 11.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 3 / 4 | Cited 100 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Kun Hu: h-index 50 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34179863) |
| Free to read | 2 / 2 | Free to read |
| Total | 62 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/s2666-7568(20)30015-5
- PubMed: 34179863
- Original source →
- Free full text: The Lancet Healthy Longevity →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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