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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,726–10,750 of 27,380 studies, newest first · page 430 of 1096.

January 2021 25

  1. 2021 year only

    Neuropsychiatric symptoms associated with family caregiver burden and depression

    ✓ Peer-reviewed Caregiving Dementia & neuropsychologia

    Key finding: Among the 12 neuropsychiatric symptoms investigated, 10 were significantly associated with caregiver burden, while 8 showed significant correlations with depressive symptoms. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021 year only

    Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction

    ✓ Peer-reviewed Disease mechanisms Journal of Alzheimer's disease : JAD

    Key finding: P021 treatment during early development prevented cognitive impairment and increased expressions of pCREB and BDNF that activated downstream various signaling cascades such as PLC/PKC, MEK/ERK and PI3K/Akt, and ameliorated synaptic protein deficit in 4-month-old 3xTg-AD mice. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2021 year only

    Multiple Neurodegenerative Pathologies in an Alzheimer's Disease Patient Treated with Fornical Deep Brain Stimulation

    ✓ Peer-reviewed Brain tissue and pathology Journal of Alzheimer's disease : JAD

    Key finding: We discuss the possible mechanisms of these overlapping neurodegenerative disorders and caution that future studies of DBS for AD will need to take these findings into consideration.

    Full summary, score breakdown and related studies → Original source

  4. 2021 year only

    Experimental Rodent Models of Vascular Dementia: A Systematic Review

    ✓ Peer-reviewed Vascular contributions CNS & neurological disorders drug targets

    Key finding: The main causes of Vascular Cognitive Impairment (VCI) are severe hypoperfusion, stroke, hypertension, large vessel disease (cortical), small Vessel Disease (subcortical VaD), strategic infarct, hemorrhage (microbleed), Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), and Cerebral Amyloid Angiopathy (CAA), which leads to decreased cerebrovascular perfusion. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021 year only

    The pericyte: A critical cell in the pathogenesis of CADASIL

    ✓ Peer-reviewed Vascular contributions Cerebral circulation - cognition and behavior

    Key finding: Based on a thorough review of morphological lesions in arteries, veins, and capillaries in CADASIL, we surmise that arteriolar and capillary pericyte damage or deficiency appears a key feature in the pathogenesis of the disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021 year only

    Cerebrovascular and Neurodegenerative Pathologies in Long-Term Stable Mild Cognitive Impairment

    ✓ Peer-reviewed Vascular contributions Journal of Alzheimer's disease : JAD

    Key finding: Alzheimer's disease pathology (Aβ plaques, neurofibrillary tangles, and cerebral amyloid angiopathy) was significantly higher in the dMCI group than the sMCI group. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021 year only

    Modulation of Gut-Brain Axis by Probiotics: A Promising Anti-depressant Approach

    ✓ Peer-reviewed Disease mechanisms Current neuropharmacology

    Key finding: Apart from this, the gut microbiota also maintains healthy communication with other body parts, including the brain. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021 year only

    The role of the microbiota-gut-brain axis in neuropsychiatric disorders

    ✓ Peer-reviewed Disease mechanisms Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    Key finding: Evidence indicates that intestinal microbiota are involved in neurological and psychiatric disorders.

    Full summary, score breakdown and related studies → Original source

  9. 2021 year only

    The NLRP3 Inflammasome in the Pathogenesis and Treatment of Alzheimer's Disease

    ✓ Peer-reviewed Inflammation and the immune system Journal of Alzheimer's disease : JAD

    Key finding: Although AD is one of the most socioeconomically devastating diseases confronting humanity, no "curative" disease modifying drug has been identified. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021 year only

    Neuroinflammation in Alzheimer's Disease: Focus on NLRP1 and NLRP3 Inflammasomes

    ✓ Peer-reviewed Inflammation and the immune system Current protein & peptide science

    Key finding: Experimental models of AD have suggested that Aβ accumulation induces, through microglia, activation of the NLRP3 inflammasome.

    Full summary, score breakdown and related studies → Original source

  11. 2021 year only

    Innate Immunity and Cell Death in Alzheimer's Disease

    ✓ Peer-reviewed Inflammation and the immune system ASN neuro

    Key finding: Recent research in the field of AD has shown that the innate immune-sensing ability of pattern recognition receptors on brain-resident macrophages, known as microglia, initiates neuroinflammation, Aβ accumulation, neuronal loss, and memory decline in patients with AD.

    Full summary, score breakdown and related studies → Original source

  12. 2021 year only

    NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer's Disease

    ✓ Peer-reviewed Inflammation and the immune system Journal of Alzheimer's disease : JAD

    Key finding: However, evidence showed that chronic inflammatory responses, with long-lasting exacerbated release of proinflammatory cytokines by reactive glial cells, contribute to the pathophysiology of the disease.

    Full summary, score breakdown and related studies → Original source

  13. 2021 year only

    Long Chain Omega-3 Fatty Acid Intervention in Ageing Adults at Risk of Dementia Following Repeated Head Trauma. Low-level Support or an Opportunity for an Unanswered Question?

    ✓ Peer-reviewed Prevention and risk The journal of prevention of Alzheimer's disease

    Key finding: We conducted a systematic review of n-3FA therapeutic efficacy for ageing adults at risk of AD/CTE following a history of repeated head trauma. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021 year only

    Mediterranean Diet Polyphenols: Anthocyanins and Their Implications for Health

    ✓ Peer-reviewed Prevention and risk Mini reviews in medicinal chemistry

    Key finding: The MD is characterized by the intake of the high amount of vegetables, fruit, and cereals and regular but moderate consumption of wine, fish, and dairy products, while olive oil is the main source of culinary fat. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2021 year only

    Fine Particulate Matter and Markers of Alzheimer's Disease Neuropathology at Autopsy in a Community-Based Cohort

    ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

    Key finding: 10-year average (SD) PM2.5 from death across the autopsy cohort was 8.2 (1.9) μg/m3. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021 year only

    Particulate Matter Exposure Exacerbates Amyloid-β Plaque Deposition and Gliosis in APP/PS1 Mice

    ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

    Key finding: The Aβ plaque load was significantly increased in the hippocampus of PM2.5-exposed APP/PS1 mice compared to their respective FA controls. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021 year only

    Urban Air Pollution Nanoparticles from Los Angeles: Recently Decreased Neurotoxicity

    ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

    Key finding: Five older nPM batches (2009-2017) and four recent nPM batches (2018, 2019) for NF-κB and Nrf2 induction showed declines in nPM potency after 2017 that paralleled declines of in vivo activity from independent exposures in different years. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021 year only

    Social Connectivity is Related to Mild Cognitive Impairment and Dementia

    ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

    Key finding: Among 952 participants (mean age at first neuropsychological assessment = 69±8 years, 62% women, 17% Black, 13% white, 68% Hispanic), 24% developed MCI/dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021 year only

    Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders

    ✓ Peer-reviewed Risk factors Current topics in behavioral neurosciences

    Key finding: Evidence from epidemiological studies on the general population suggests that midlife cardiovascular disease (CVD) and/or metabolic syndrome (MetS) are associated with an increased risk of cognitive impairment and dementia later in life. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021 year only

    Glucose-Dementia Association Is Consistent Over Blood Pressure/Antihypertensive Groups

    ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

    Key finding: A total of 3,056 participants without diabetes treatment and 480 with diabetes treatment were included (mean age at baseline, 75.1 years; mean 7.5 years of follow-up). +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021 year only

    Metabolic Syndrome, Alzheimer's Disease, and Covid 19: A Possible Correlation

    ✓ Peer-reviewed Risk factors Current Alzheimer research

    Key finding: Patients with Alzheimer's disease and risk factors associated with dementia may also be more vulnerable to serious COVID-19 infection.

    Full summary, score breakdown and related studies → Original source

  22. 2021 year only

    Unique Sleep and Circadian Rhythm Dysfunction Neuroinflammatory and Immune Profiles in Alzheimer's Disease with Mild Cognitive Impairment

    ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

    Key finding: On the other hand, sleep disruption was more so associated with abnormalities in circulating markers of immunity and inflammation and decrements in cognition.

    Full summary, score breakdown and related studies → Original source

  23. 2021 year only

    Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk

    ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD

    Key finding: Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was -0.16 (95 %CI -0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04-6.50%.

    Full summary, score breakdown and related studies → Original source

  24. 2021 year only

    Safety and Tolerability of GRF6019 Infusions in Severe Alzheimer's Disease: A Phase II Double-Blind Placebo-Controlled Trial

    ✓ Peer-reviewed Clinical trials Journal of Alzheimer's disease : JAD

    Key finding: All patients completed 100%of study visits and infusions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021 year only

    Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors

    ✓ Peer-reviewed Treatments Current neuropharmacology

    Key finding: The aim of this work is to review tacrine analogues from the last three years, which were not included in the latest review work, donepezil and galantamine hybrids from 2015 and rivastigmine derivatives from 2014. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →