Newest studies

Neurodegenerative disorders: A Holistic study of the explainable artificial intelligence applications

42/100 ✓ Peer-reviewed Digital health tools Engineering Applications of Artificial Intelligence

Key finding: It organizes XAI methods into groups and talks about their pros, cons, and clinical importance. +4 more findings

• Digital Tools

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Global trends in prevalence, disability adjusted life years, and risk factors for early onset dementia from 1990 to 2021

43/100 ✓ Peer-reviewed How common it is Scientific Reports

Key finding: A significant negative correlation was found between SDI and ASDR. +1 more finding

• Risk Factors

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Systolic blood pressure variability: risk of cardiovascular events, chronic kidney disease, dementia, and death

52/100 ✓ Peer-reviewed Caregiving European Heart Journal

Key finding: A total of 36 251 participants were included with a median follow-up time of 13.9 years. +4 more findings

• Risk Factors

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Characterizing risk and protective factors for Alzheimer's disease and related dementias in American Samoa

34/100 ✓ Peer-reviewed Getting a diagnosis SSM - Mental Health

Key finding: • Understudied Native Hawaiian and Pacific Islander populations in Alzheimer's Disease and Related Dementia. • Risk and resiliency factors in Alzheimer's Disease and Related Dementia for American Samoa adults. • Using the Kimberley Indigenous Cognitive Assessment tool to determine ADRD potentially modifiable risk and protective factors.

• Prevention

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Racial and Ethnic Differences in Amyloid PET Positivity in Individuals With Mild Cognitive Impairment or Dementia

49/100 ✓ Peer-reviewed Biomarkers Carolina Digital Repository (University of North Carolina at Chapel Hill)

Key finding: Data from 17 107 individuals (321 Asian, 635 Black, 829 Hispanic, and 15 322 White) with MCI or dementia and amyloid PET were analyzed between April 2020 and January 2022. +4 more findings

• Health Equity
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease

65/100 ✓ Peer-reviewed Biomarkers Molecular psychiatry

Key finding: The results showed that baseline plasma p181 levels were elevated and increased more rapidly in A + SCD individuals compared to amyloid-positive cognitively unimpaired (A + CU) individuals (stage 1). +1 more finding

• Biomarkers
• Early Stage

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[18F]Florzolotau PET for the Differential Diagnosis of Parkinsonism in Patients with Suspected 4-Repeat Tauopathies

45/100 ✓ Peer-reviewed Disease mechanisms Journal of Nuclear Medicine

Key finding: The 4R-like pattern was more prevalent and more strongly expressed (84.3%, mean score, 2.0 ± 1.1) in patients with a consensus diagnosis of PSP/CBD (joint diagnostic group of clinically likely 4R tauopathies) than in all other groups (11.6%, 0.26 ± 0.75, P < 0.0001). +4 more findings

• Diagnosis
• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Eye tracking based detection of mild cognitive impairment: A review

39/100 ✓ Peer-reviewed Mild cognitive impairment Information Fusion

Key finding: MCI presents a higher risk of progressing to Alzheimer’s and other neurodegenerative conditions despite its early symptoms overlapping with normal cognitive aging.

• Early Stage
• Digital Tools

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Brain network connectivity underlying neuropsychiatric symptoms in prodromal Lewy body dementia

44/100 ✓ Peer-reviewed Lewy body dementia Neurobiology of Aging

Key finding: Neuropsychiatric symptoms (NPS) are prevalent, emerge early, and are associated with poorer outcomes in Lewy body dementia (LBD). +4 more findings

• Other Dementias
• Early Stage

Full summary, score breakdown and related studies → Original source

Visual Hallucinations in Serotonergic Psychedelics and Lewy Body Diseases

40/100 ✓ Peer-reviewed Lewy body dementia Schizophrenia Bulletin

Key finding: Both LBDs and SPs exhibit distinct visual aberrations, ranging from minor metamorphopsias to complex hallucinations. +4 more findings

• Other Dementias

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The Role of Oxidative Stress and Inflammation in the Pathogenesis and Treatment of Vascular Dementia

44/100 ✓ Peer-reviewed Lewy body dementia Cells

Key finding: These conditions contribute to neuronal damage, synaptic dysfunction, and cognitive decline. +4 more findings

• Brain Biology
• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

The story of pain in people with dementia: a rationale for digital measures

42/100 ✓ Peer-reviewed Digital health tools BMC Medicine

Key finding: Digital phenotyping based on physiological parameters and sensing technology may increase pain assessment objectivity in older adults with dementia. +1 more finding

• Digital Tools

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Evaluation of AccuBrain-based MRI quantitative analysis in diagnosing Alzheimer’s disease and assessing behavioral and psychological symptoms of dementia

38/100 ✓ Peer-reviewed Getting a diagnosis Aging Clinical and Experimental Research

Key finding: AD patients had significantly higher AD-RAI (0.91 ± 0.25) and more pronounced hippocampal atrophy (0.36 ± 0.09) compared to MCI and HC (P 0.9 for distinguishing BPSD from non-BPSD patients. +2 more findings

• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

Factors associated with dementia risk reduction lifestyle in mild cognitive impairment: a cross-sectional study of individuals and their family caregivers

45/100 ✓ Peer-reviewed Prevention and risk BMC Neurology

Key finding: DRRLS score of 83.61 ± 16.13, multiple linear regression showed that the patient's monthly individual income, the presence of chronic disease, health beliefs, and social support were independent influences on their dementia risk reduction lifestyle. +4 more findings

• Caregiving
• Prevention
• Early Stage

Full summary, score breakdown and related studies → Original source

Population Attributable Fraction of Incident Dementia Associated With Hearing Loss

63/100 ✓ Peer-reviewed Prevention and risk JAMA Otolaryngology–Head & Neck Surgery

Key finding: Among 2946 participants (mean [SD] age, 74.9 [4.6] years; 1751 [59.4] female; 637 Black [21.6%] and 2309 White [78.4%] individuals), 1947 participants (66.1%) had audiometric hearing loss, and 1097 (37.2%) had self-reported hearing loss. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

TREM2 and sTREM2 in Alzheimer's disease: from mechanisms to therapies

51/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

Key finding: Recent studies have established TREM2 as a central immune signaling hub in neurodegeneration, where it triggers immune responses upon sensing pathological development and tissue damages. +3 more findings

• Genetics

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Patient journey and decision processes for anti-amyloid therapy in Alzheimer's disease

57/100 ✓ Peer-reviewed Treatments Journal of neurology

Key finding: From an initial sample (N = 2499), 1064 patients (55,000 notes) were reviewed manually (mean age 76 years; 7.3% women; 9.2% Black; 3.9% Hispanic). +4 more findings

• Treatments

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Re-evaluation of the efficacy and safety of anti-Aβ monoclonal antibodies (lecanemab/donanemab) in the treatment of early Alzheimer's disease

72/100 ✓ Peer-reviewed Treatments Frontiers in pharmacology

Key finding: Lecanemab/Donanemab can improve memory, cognitive function, and daily living abilities in patients with early AD, significantly reduce the composite score of Alzheimer's disease, and inhibit the accumulation of amyloid peptides, thereby alleviating symptoms and improving the condition. +4 more findings

• Treatments
• Side Effects
• Brain Biology

Full summary, score breakdown and related studies → Original source

The Status of Neuroimaging with SPECT and PET in Germany: Results from the 1st Survey on Nuclear Neuroimaging in Germany in 2023

37/100 ✓ Peer-reviewed Health systems and care delivery Nuklearmedizin. Nuclear medicine

Key finding: The advent of disease-modifying therapies for neurodegenerative diseases may result in a growing demand for nuclear neuroimaging procedures presenting opportunities but also challenges to the nuclear medicine community.

• Brain Scans
• Treatments

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The relationship of 18 F-FDG-PET to other common biomarkers of dementia in a clinical cohort with memory deficits

41/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer s Disease Reports

Key finding: The study highlights the potential of integrating 18 F-FDG-PET with CSF biomarkers to improve the diagnosis, prognosis, and monitoring of AD, emphasizing the complexity and regional specificity of biomarker interactions in neurodegeneration.

• Brain Scans
• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

Amyotrophic lateral sclerosis and frontotemporal dementia mutation reduces endothelial TDP-43 and causes blood-brain barrier defects

44/100 ✓ Peer-reviewed Lewy body dementia Science Advances

Key finding: Because blood-brain barrier (BBB) permeability increases in ALS-FTD, we postulated that reduced nuclear TDP-43 in ECs might contribute. +4 more findings

• Other Dementias
• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Prediction of Alzheimer's Dementia Using Soft Voting Ensemble Learning with Machine Learning

40/100 ✓ Peer-reviewed Digital health tools IJACI International Journal of Advanced Computing and Informatics

Key finding: The experimental results show that the combination of the Random Over Sampling (ROS) resampling method and grid search hyperparameter tuning for the Gradient Boosting algorithm achieved the best results, with an accuracy of 97%.

• Digital Tools

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Using machine learning and electronic health record (EHR) data for the early prediction of Alzheimer's Disease and Related Dementias

56/100 ✓ Peer-reviewed How common it is The Journal of Prevention of Alzheimer s Disease

Key finding: The GBT model achieved the best AUC-ROC scores of 0.809-0.833 across 1- to 5-year prediction windows. +3 more findings

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Global Prevalence, Incidence, and Factors Influencing Falls in Older Adults With Dementia: Implications for Nursing and Healthy Aging

61/100 ✓ Peer-reviewed How common it is Journal of Nursing Scholarship

Key finding: This meta-analysis included 21 studies involving 35,449 participants. +4 more findings

• Risk Factors

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Air pollution, lifestyle, and cardiovascular disease risk in northwestern China: A cohort study of over 5.8 million participants

48/100 ✓ Peer-reviewed Prevention and risk Environment International

Key finding: Long-term exposure to particulate matter (PM 1 , PM 2.5 , PM 10 ), ozone (O 3 ), and carbon monoxide (CO) was significantly associated with increased CVD risk. +3 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source