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Spicy food consumption is associated with cognition and cerebrospinal fluid biomarkers of Alzheimer disease
Tian DY, Wang J, Sun BL, Wang Z, Xu W, Chen Y, Shen YY, Li HY et al.. Chinese medical journal, 2020-12-21
Topic: Amyloid, tau and blood-test diagnosis
Background Recent studies suggest that a healthy diet helps to prevent the development of Alzheimer disease (AD). This study aimed to investigate whether spicy food consumption is associated with cognition and cerebrospinal fluid (CSF) biomarkers of AD in the Chinese population. Methods We enrolled 55 AD patients and 55 age- and gender-matched cognitively normal (CN) subjects in a case-control study, as well as a cohort of 131 participants without subjective cognitive decline (non-AD) in a cross-sectional study.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Tian, D. Y., Wang, J., Sun, B. L., Wang, Z., Xu, W., Chen, Y., et al. (2020). Spicy food consumption is associated with cognition and cerebrospinal fluid biomarkers of Alzheimer disease. Chinese medical journal. https://doi.org/10.1097/cm9.0000000000001318
Vancouver
Tian DY, Wang J, Sun BL, Wang Z, Xu W, Chen Y, et al. Spicy food consumption is associated with cognition and cerebrospinal fluid biomarkers of Alzheimer disease. Chinese medical journal. 2020. doi:10.1097/cm9.0000000000001318. PMID: 33443937.
BibTeX
@article{tian2020-33443937,
author = {Tian, D. Y. and Wang, J. and Sun, B. L. and Wang, Z. and Xu, W. and Chen, Y. and Shen, Y. Y. and Li, H. Y. and others},
title = {{Spicy food consumption is associated with cognition and cerebrospinal fluid biomarkers of Alzheimer disease}},
journal = {Chinese medical journal},
year = {2020},
doi = {10.1097/cm9.0000000000001318},
pmid = {33443937},
url = {https://doi.org/10.1097/cm9.0000000000001318}
}
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Key findings
- This study aimed to investigate whether spicy food consumption is associated with cognition and cerebrospinal fluid (CSF) biomarkers of AD in the Chinese population.
- Methods We enrolled 55 AD patients and 55 age- and gender-matched cognitively normal (CN) subjects in a case-control study, as well as a cohort of 131 participants without subjective cognitive decline (non-AD) in a cross-sectional study.
- Spicy food consumption was assessed using the Food Frequency Questionnaire (FFQ).
- Associations of FFQ scores with cognition and CSF biomarkers of AD were analyzed.
Why it matters
This study investigated whether eating spicy food is associated with cognition and spinal fluid biomarkers of Alzheimer's disease in a Chinese population. It is an observational study and cannot show that spicy food causes or prevents Alzheimer's disease.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Study designcase-control study
- Participants55
- Evidence strengthModerate
How this study scored 50/100
Published in a peer-reviewed journal, and it is a case-control study. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Chinese medical journal) |
| Journal's citation record | 1 / 4 | Chinese Medical Journal: journal h-index 94 (OpenAlex, 2026-10-29) |
| Study design | 6 / 12 | A case-control study |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 55 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 16 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.0 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 2 / 6 | Cited 1.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Yan‐Jiang Wang: h-index 67 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Fudan University: institution h-index 954 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33443937) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1097/cm9.0000000000001318
- PubMed: 33443937
- Original source →
- Free full text: Chinese Medical Journal →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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