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Modulation of Gut-Brain Axis by Probiotics: A Promising Anti-depressant Approach
Koumudhi Rajanala, Nitesh Kumar, Mallikarjuna Rao Chamallamudi. Current neuropharmacology, 2021
Topic: Gut, metabolism and diet
The human digestive system is embedded with trillions of microbes of various species and genera. These organisms serve several purposes in the human body and exist in symbiosis with the host. Their major role is involved in the digestion and conversion of food materials into many useful substrates for the human body. Apart from this, the gut microbiota also maintains healthy communication with other body parts, including the brain. The connection between gut microbiota and the brain is termed as gut-brain axis (GBA), and these connections are established by neuronal, endocrine and immunological pathways. Thus, they are involved in neurophysiology and neuropathology of several diseases like Parkinson's disease (PD), Alzheimer's disease (AD), depression, and autism. There are several food supplements such as prebiotics and probiotics that modulate the composition of gut microbiota. This article provides a review about the role of gut microbiota in depression and supplements such as probiotics that are useful in the treatment of depression.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Rajanala, K., Kumar, N., & Chamallamudi, M. R. (2021). Modulation of Gut-Brain Axis by Probiotics: A Promising Anti-depressant Approach. Current neuropharmacology. https://doi.org/10.2174/1570159x19666201215142520
Vancouver
Rajanala K, Kumar N, Chamallamudi MR. Modulation of Gut-Brain Axis by Probiotics: A Promising Anti-depressant Approach. Current neuropharmacology. 2021. doi:10.2174/1570159x19666201215142520. PMID: 33327916.
BibTeX
@article{rajanala2021-33327916,
author = {Rajanala, Koumudhi and Kumar, Nitesh and Chamallamudi, Mallikarjuna Rao},
title = {{Modulation of Gut-Brain Axis by Probiotics: A Promising Anti-depressant Approach}},
journal = {Current neuropharmacology},
year = {2021},
doi = {10.2174/1570159x19666201215142520},
pmid = {33327916},
url = {https://doi.org/10.2174/1570159x19666201215142520}
}
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Key findings
- Apart from this, the gut microbiota also maintains healthy communication with other body parts, including the brain.
- The connection between gut microbiota and the brain is termed as gut-brain axis (GBA), and these connections are established by neuronal, endocrine and immunological pathways.
- Thus, they are involved in neurophysiology and neuropathology of several diseases like Parkinson's disease (PD), Alzheimer's disease (AD), depression, and autism.
- There are several food supplements such as prebiotics and probiotics that modulate the composition of gut microbiota.
- This article provides a review about the role of gut microbiota in depression and supplements such as probiotics that are useful in the treatment of depression.
Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Current neuropharmacology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33327916) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
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