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Glucose-Dementia Association Is Consistent Over Blood Pressure/Antihypertensive Groups
Jing Zhou, Rod L Walker, Shelly L Gray, Zachary A Marcum, Douglas Barthold, James D Bowen, Wayne McCormick, Susan M McCurry et al.. Journal of Alzheimer's disease : JAD, 2021
Topic: Health services, long-term care and technology
A total of 3,056 participants without diabetes treatment and 480 with diabetes treatment were included (mean age at baseline, 75.1 years; mean 7.5 years of follow-up). Higher glucose levels were associated with greater dementia risk among people without and with treated diabetes. Hazard ratios for dementia were similar across all blood pressure/antihypertensive treatment groups (omnibus p = 0.82 for people without and p = 0.59 for people with treated diabetes). Hypertension and antihypertensive treatments do not appear to affect the association between glucose and dementia risk in this population-based longitudinal cohort study of community-dwelling older adults. Future studies are needed to examine this question in midlife and by specific antihypertensive treatments.
Key findings
- A total of 3,056 participants without diabetes treatment and 480 with diabetes treatment were included (mean age at baseline, 75.1 years; mean 7.5 years of follow-up).
- Higher glucose levels were associated with greater dementia risk among people without and with treated diabetes.
- Hazard ratios for dementia were similar across all blood pressure/antihypertensive treatment groups (omnibus p = 0.82 for people without and p = 0.59 for people with treated diabetes).
- Hypertension and antihypertensive treatments do not appear to affect the association between glucose and dementia risk in this population-based longitudinal cohort study of community-dwelling older adults.
- Future studies are needed to examine this question in midlife and by specific antihypertensive treatments.
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Study details
- Study designcohort study
- Participants3,056
- Evidence strengthModerate
How this study scored 68/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 38 of the 56 points we could judge it on, which is 68 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 3,056 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33554906) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 38 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 38 of the 56 points we could judge it on is 68 out of 100. |
| Total | 68 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Zhou, J., Walker, R. L., Gray, S. L., Marcum, Z. A., Barthold, D., Bowen, J. D., et al. (2021). Glucose-Dementia Association Is Consistent Over Blood Pressure/Antihypertensive Groups. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-201138
Vancouver
Zhou J, Walker RL, Gray SL, Marcum ZA, Barthold D, Bowen JD, et al. Glucose-Dementia Association Is Consistent Over Blood Pressure/Antihypertensive Groups. Journal of Alzheimer's disease : JAD. 2021. doi:10.3233/jad-201138. PMID: 33554906.
BibTeX
@article{zhou2021-33554906,
author = {Zhou, Jing and Walker, Rod L and Gray, Shelly L and Marcum, Zachary A and Barthold, Douglas and Bowen, James D and McCormick, Wayne and McCurry, Susan M and others},
title = {{Glucose-Dementia Association Is Consistent Over Blood Pressure/Antihypertensive Groups}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2021},
doi = {10.3233/jad-201138},
pmid = {33554906},
url = {https://doi.org/10.3233/jad-201138}
}
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