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Assessment of the DTI-ALPS Parameter Along the Perivascular Space in Older Adults at Risk of Dementia
Steward CE, Venkatraman VK, Lui E, Malpas CB, Ellis KA, Cyarto EV, Vivash L, O'Brien TJ et al.. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2021-02-08
Topic: Risk, prevention and care in population studies
Background and purpose Recently, there has been growing interest in the glymphatic system (the functional waste clearance pathway for the central nervous system and its role in flushing solutes (such as amyloid ß and tau), metabolic, and other cellular waste products in the brain. Herein, we investigate a recent potential biomarker for glymphatic activity (the diffusion tensor imaging along the perivascular space [DTI-ALPS] parameter) using diffusion MRI imaging in an elderly cohort comprising 10 cognitively normal, 10 mild cognitive impairment (MCI), and 16 Alzheimer's disease (AD). Methods All 36 participants imaged on a Siemens 3.0T Tim Trio.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Steward, C. E., Venkatraman, V. K., Lui, E., Malpas, C. B., Ellis, K. A., Cyarto, E. V., et al. (2021). Assessment of the DTI-ALPS Parameter Along the Perivascular Space in Older Adults at Risk of Dementia. Journal of neuroimaging : official journal of the American Society of Neuroimaging. https://doi.org/10.1111/jon.12837
Vancouver
Steward CE, Venkatraman VK, Lui E, Malpas CB, Ellis KA, Cyarto EV, et al. Assessment of the DTI-ALPS Parameter Along the Perivascular Space in Older Adults at Risk of Dementia. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2021. doi:10.1111/jon.12837. PMID: 33556226.
BibTeX
@article{steward2021-33556226,
author = {Steward, C. E. and Venkatraman, V. K. and Lui, E. and Malpas, C. B. and Ellis, K. A. and Cyarto, E. V. and Vivash, L. and O'Brien, T. J. and others},
title = {{Assessment of the DTI-ALPS Parameter Along the Perivascular Space in Older Adults at Risk of Dementia}},
journal = {Journal of neuroimaging : official journal of the American Society of Neuroimaging},
year = {2021},
doi = {10.1111/jon.12837},
pmid = {33556226},
url = {https://doi.org/10.1111/jon.12837}
}
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Key findings
- Herein, we investigate a recent potential biomarker for glymphatic activity (the diffusion tensor imaging along the perivascular space [DTI-ALPS] parameter) using diffusion MRI imaging in an elderly cohort comprising 10 cognitively normal, 10 mild cognitive impairment (MCI), and 16 Alzheimer's disease (AD).
- Methods All 36 participants imaged on a Siemens 3.0T Tim Trio.
- Single-SE diffusion weighted Echo-planar imaging scans were acquired as well as T1 magnetization prepared rapid gradient echo, T2 axial, and susceptibility weighted imaging.
- Three millimeter regions of interest were drawn in the projection and association fibers adjacent to the medullary veins at the level of the lateral ventricle.
Why it matters
This small imaging study of 36 people examined a possible MRI marker of glymphatic activity across cognitively normal, mild cognitive impairment, and Alzheimer's disease groups. It is early biomarker work in a small sample, not evidence about treating, curing or preventing the disease.
Study details
- Participants36
- Evidence strengthModerate
How this study scored 54/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuroimaging : official journal of the American Society of Neuroimaging) |
| Journal's citation record | 1 / 4 | Journal of Neuroimaging: journal h-index 91 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 36 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 180 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 25.7 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 4 / 6 | Cited 9.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 3 / 4 | Cited 117 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Patricia M. Desmond: h-index 86 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | The University of Melbourne: institution h-index 1,342 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33556226) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 54 / 100 | — |
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