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Resting state EEG biomarkers of cognitive decline associated with Alzheimer's disease and mild cognitive impairment
Meghdadi AH, Stevanović Karić M, McConnell M, Rupp G, Richard C, Hamilton J, Salat D, Berka C.. PloS one, 2021-02-05
Topic: Amyloid, tau and blood-test diagnosis
Compared to age matched controls, in the AD group, we found increases in both spectral power and coherence at the slower frequencies (Delta, Theta). A smaller but significant increase in power of slow frequencies was observed for the MCI group, localized to temporal areas. The AD group showed a significant decrease in the spectral power and coherence in the Alpha band consistent with the same effect in normal aging. However, the MCI group did not show any significant change in the Alpha band. Overall, Theta to Alpha ratio (TAR) provided the largest and most significant differences between the AD group and controls. Compared to average TAR, using PDDF enhanced the statistical significance, the effect size, and the spatial distribution of significant effects in the MCI group. Posterior probability of AD, TAR, and the proposed PDDM measure were all significantly correlated with MMSE score and neuropsychological tests in the AD group.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Meghdadi, A. H., Stevanović Karić, M., McConnell, M., Rupp, G., Richard, C., Hamilton, J., et al. (2021). Resting state EEG biomarkers of cognitive decline associated with Alzheimer's disease and mild cognitive impairment. PloS one. https://doi.org/10.1371/journal.pone.0244180
Vancouver
Meghdadi AH, Stevanović Karić M, McConnell M, Rupp G, Richard C, Hamilton J, et al. Resting state EEG biomarkers of cognitive decline associated with Alzheimer's disease and mild cognitive impairment. PloS one. 2021. doi:10.1371/journal.pone.0244180. PMID: 33544703.
BibTeX
@article{meghdadi2021-33544703,
author = {Meghdadi, A. H. and Stevanović Karić, M. and McConnell, M. and Rupp, G. and Richard, C. and Hamilton, J. and Salat, D. and Berka, C.},
title = {{Resting state EEG biomarkers of cognitive decline associated with Alzheimer's disease and mild cognitive impairment}},
journal = {PloS one},
year = {2021},
doi = {10.1371/journal.pone.0244180},
pmid = {33544703},
url = {https://doi.org/10.1371/journal.pone.0244180}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Compared to age matched controls, in the AD group, we found increases in both spectral power and coherence at the slower frequencies (Delta, Theta).
- A smaller but significant increase in power of slow frequencies was observed for the MCI group, localized to temporal areas.
- The AD group showed a significant decrease in the spectral power and coherence in the Alpha band consistent with the same effect in normal aging.
- However, the MCI group did not show any significant change in the Alpha band.
- Overall, Theta to Alpha ratio (TAR) provided the largest and most significant differences between the AD group and controls.
Why it matters
This study found changes in resting-state brain wave patterns in people with Alzheimer's disease, and smaller changes in people with mild cognitive impairment, with the theta to alpha ratio showing the largest difference between Alzheimer's patients and controls. These are candidate biomarkers for detecting decline, not a treatment, cure, or prevention.
Study details
- Participants26
- Effect sizeAUC = 0.85; AUC = 0.6
- Evidence strengthLow
How this study scored 62/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (PloS one) |
| Journal's citation record | 4 / 4 | PLoS ONE: journal h-index 594 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 26 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 235 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 33.6 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 5 / 6 | Cited 23.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 9 other studies in this library |
| Still being cited | 3 / 4 | Cited 138 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Chris Berka: h-index 25 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33544703) |
| Free to read | 2 / 2 | Free to read |
| Total | 62 / 100 | — |
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