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Sarcopenia is associated with incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline
Beeri MS, Leugrans SE, Delbono O, Bennett DA, Buchman AS.. Journal of the American Geriatrics Society, 2021-05-05
Topic: Amyloid, tau and blood-test diagnosis
Objective We examined whether sarcopenia is associated with the occurrence of late-life cognitive impairment. Methods Nondemented older adults (N = 1175) underwent annual testing with 17 cognitive tests summarized as a global cognitive score. A composite sarcopenia score was constructed based on muscle mass measured with bioelectrical impedance and muscle function based on grip strength.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Beeri, M. S., Leugrans, S. E., Delbono, O., Bennett, D. A., & Buchman, A. S. (2021). Sarcopenia is associated with incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.17206
Vancouver
Beeri MS, Leugrans SE, Delbono O, Bennett DA, Buchman AS. Sarcopenia is associated with incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Journal of the American Geriatrics Society. 2021. doi:10.1111/jgs.17206. PMID: 33954985.
BibTeX
@article{beeri2021-33954985,
author = {Beeri, M. S. and Leugrans, S. E. and Delbono, O. and Bennett, D. A. and Buchman, A. S.},
title = {{Sarcopenia is associated with incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline}},
journal = {Journal of the American Geriatrics Society},
year = {2021},
doi = {10.1111/jgs.17206},
pmid = {33954985},
url = {https://doi.org/10.1111/jgs.17206}
}
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Key findings
- Methods Nondemented older adults (N = 1175) underwent annual testing with 17 cognitive tests summarized as a global cognitive score.
- A composite sarcopenia score was constructed based on muscle mass measured with bioelectrical impedance and muscle function based on grip strength.
- Cox proportional hazard models were employed to examine associations of sarcopenia with incident Alzheimer's dementia (AD) and incident mild cognitive impairment (MCI).
- Linear mixed-effect models determined the association of sarcopenia with cognitive decline.
Why it matters
In 1175 nondemented older adults, sarcopenia was associated with incident Alzheimer's dementia, mild cognitive impairment and cognitive decline. This is an observational association study and does not report any treatment, cure or prevention for Alzheimer's disease.
Study details
- Participants1,175
- Evidence strengthLow
How this study scored 56/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Geriatrics Society) |
| Journal's citation record | 3 / 4 | Journal of the American Geriatrics Society: journal h-index 344 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,175 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 235 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 33.6 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 4 / 6 | Cited 16.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 3 / 4 | Cited 152 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Aron S. Buchman: h-index 88 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Icahn School of Medicine at Mount Sinai: institution h-index 1,331 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33954985) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 56 / 100 | — |
What each of these 20 components measures, and what this score is not →
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